Calcium pretreatment enhances fluoride reactivity with enamel and dentine
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.archoralbio.2021.105338 http://hdl.handle.net/11449/237555 |
Resumo: | Objective: High fluoride concentration treatments are known to react with enamel and dentine forming calcium fluoride (CaF2)-like deposits, but strategies to improve this reactivity beyond increasing fluoride concentration/ reducing pH in fluoride treatments have not been explored. Here we investigated the ability of a calcium pretreatment to improve fluoride reactivity.& nbsp;Design: In a blind and randomized in vitro study, sound and carious enamel and dentine slabs (n = 11/group) were randomly allocated into one of the following treatments: Deionized water (negative control); 0.05% sodium fluoride (F, positive control); 150 mM calcium lactate solution followed by 0.05% sodium fluoride solution (Ca-*F); 150 mM calcium lactate solution premixed with 0.05% sodium fluoride solution (CaF2, active control). Alkali-soluble fluoride (representing CaF2-like deposits formed on the substrates) was extracted from the slabs using 1 M KOH for 24 h and measured by an ion-specific electrode. Carious slabs were further observed under scanning electron microscopy (SEM). Data were analyzed by two-way ANOVA followed by Tukey test.& nbsp;Results: The Ca-*F treatment enhanced fluoride reactivity with all tested substrates when compared with F alone. Carious substrates had a greater reactivity with F and Ca-*F than their respective sound substrates, confirming that increased porosity enhances the reactivity with fluoride. Alkali-soluble fluoride concentration after the CaF(2 & nbsp;)treatment did not differ among the different substrates, suggesting this treatment causes only contamination with preformed CaF2, which was noted under SEM.& nbsp;Conclusion: A calcium pretreatment enhances the reactivity of fluoride with enamel and dentine. |
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Calcium pretreatment enhances fluoride reactivity with enamel and dentineFluorideCalcium fluorideDental cariesRootPreventionObjective: High fluoride concentration treatments are known to react with enamel and dentine forming calcium fluoride (CaF2)-like deposits, but strategies to improve this reactivity beyond increasing fluoride concentration/ reducing pH in fluoride treatments have not been explored. Here we investigated the ability of a calcium pretreatment to improve fluoride reactivity.& nbsp;Design: In a blind and randomized in vitro study, sound and carious enamel and dentine slabs (n = 11/group) were randomly allocated into one of the following treatments: Deionized water (negative control); 0.05% sodium fluoride (F, positive control); 150 mM calcium lactate solution followed by 0.05% sodium fluoride solution (Ca-*F); 150 mM calcium lactate solution premixed with 0.05% sodium fluoride solution (CaF2, active control). Alkali-soluble fluoride (representing CaF2-like deposits formed on the substrates) was extracted from the slabs using 1 M KOH for 24 h and measured by an ion-specific electrode. Carious slabs were further observed under scanning electron microscopy (SEM). Data were analyzed by two-way ANOVA followed by Tukey test.& nbsp;Results: The Ca-*F treatment enhanced fluoride reactivity with all tested substrates when compared with F alone. Carious substrates had a greater reactivity with F and Ca-*F than their respective sound substrates, confirming that increased porosity enhances the reactivity with fluoride. Alkali-soluble fluoride concentration after the CaF(2 & nbsp;)treatment did not differ among the different substrates, suggesting this treatment causes only contamination with preformed CaF2, which was noted under SEM.& nbsp;Conclusion: A calcium pretreatment enhances the reactivity of fluoride with enamel and dentine.University of Michigan College of Engineering and National Science Foundation (NSF, USA)Univ Michigan Sch Dent, Dept Cariol, Restorat Sci & Endodont, 1011 N Univ Ave, Ann Arbor, MI 48109 USAUniv Michigan, Dept Cariol Restorat Sci & Endodont, Sch Dent, 1011 N Univ Ave rm 2217, Ann Arbor, MI 48109 USAUniversity of Michigan College of Engineering and National Science Foundation (NSF, USA): DMR-1625671Elsevier B.V.Univ Michigan Sch DentUniv MichiganUniversidade Estadual Paulista (UNESP)Spinola, Manuela Da SilvaTenuta, Livia Maria Andalo2022-11-30T13:38:29Z2022-11-30T13:38:29Z2022-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5http://dx.doi.org/10.1016/j.archoralbio.2021.105338Archives Of Oral Biology. Oxford: Pergamon-elsevier Science Ltd, v. 134, 5 p., 2022.0003-9969http://hdl.handle.net/11449/23755510.1016/j.archoralbio.2021.105338WOS:000791259900003Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives Of Oral Biologyinfo:eu-repo/semantics/openAccess2022-11-30T13:38:29Zoai:repositorio.unesp.br:11449/237555Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:45.448961Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Calcium pretreatment enhances fluoride reactivity with enamel and dentine |
title |
Calcium pretreatment enhances fluoride reactivity with enamel and dentine |
spellingShingle |
Calcium pretreatment enhances fluoride reactivity with enamel and dentine Spinola, Manuela Da Silva Fluoride Calcium fluoride Dental caries Root Prevention |
title_short |
Calcium pretreatment enhances fluoride reactivity with enamel and dentine |
title_full |
Calcium pretreatment enhances fluoride reactivity with enamel and dentine |
title_fullStr |
Calcium pretreatment enhances fluoride reactivity with enamel and dentine |
title_full_unstemmed |
Calcium pretreatment enhances fluoride reactivity with enamel and dentine |
title_sort |
Calcium pretreatment enhances fluoride reactivity with enamel and dentine |
author |
Spinola, Manuela Da Silva |
author_facet |
Spinola, Manuela Da Silva Tenuta, Livia Maria Andalo |
author_role |
author |
author2 |
Tenuta, Livia Maria Andalo |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Univ Michigan Sch Dent Univ Michigan Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Spinola, Manuela Da Silva Tenuta, Livia Maria Andalo |
dc.subject.por.fl_str_mv |
Fluoride Calcium fluoride Dental caries Root Prevention |
topic |
Fluoride Calcium fluoride Dental caries Root Prevention |
description |
Objective: High fluoride concentration treatments are known to react with enamel and dentine forming calcium fluoride (CaF2)-like deposits, but strategies to improve this reactivity beyond increasing fluoride concentration/ reducing pH in fluoride treatments have not been explored. Here we investigated the ability of a calcium pretreatment to improve fluoride reactivity.& nbsp;Design: In a blind and randomized in vitro study, sound and carious enamel and dentine slabs (n = 11/group) were randomly allocated into one of the following treatments: Deionized water (negative control); 0.05% sodium fluoride (F, positive control); 150 mM calcium lactate solution followed by 0.05% sodium fluoride solution (Ca-*F); 150 mM calcium lactate solution premixed with 0.05% sodium fluoride solution (CaF2, active control). Alkali-soluble fluoride (representing CaF2-like deposits formed on the substrates) was extracted from the slabs using 1 M KOH for 24 h and measured by an ion-specific electrode. Carious slabs were further observed under scanning electron microscopy (SEM). Data were analyzed by two-way ANOVA followed by Tukey test.& nbsp;Results: The Ca-*F treatment enhanced fluoride reactivity with all tested substrates when compared with F alone. Carious substrates had a greater reactivity with F and Ca-*F than their respective sound substrates, confirming that increased porosity enhances the reactivity with fluoride. Alkali-soluble fluoride concentration after the CaF(2 & nbsp;)treatment did not differ among the different substrates, suggesting this treatment causes only contamination with preformed CaF2, which was noted under SEM.& nbsp;Conclusion: A calcium pretreatment enhances the reactivity of fluoride with enamel and dentine. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-30T13:38:29Z 2022-11-30T13:38:29Z 2022-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.archoralbio.2021.105338 Archives Of Oral Biology. Oxford: Pergamon-elsevier Science Ltd, v. 134, 5 p., 2022. 0003-9969 http://hdl.handle.net/11449/237555 10.1016/j.archoralbio.2021.105338 WOS:000791259900003 |
url |
http://dx.doi.org/10.1016/j.archoralbio.2021.105338 http://hdl.handle.net/11449/237555 |
identifier_str_mv |
Archives Of Oral Biology. Oxford: Pergamon-elsevier Science Ltd, v. 134, 5 p., 2022. 0003-9969 10.1016/j.archoralbio.2021.105338 WOS:000791259900003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives Of Oral Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129136204447744 |