Analysis of the TAX1BP1 gene in head and neck cancer patients
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1808-86942010000200008 http://hdl.handle.net/11449/42106 |
Resumo: | In Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. Aim: to assess the T. A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. Series and methods: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. Results: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p = 0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. Conclusion: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism. |
id |
UNSP_d1bb6d63b52e695ed41e93a1a59376c5 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/42106 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Analysis of the TAX1BP1 gene in head and neck cancer patientsAlcohol drinkingGeneticsHead and neck neoplasmsTobaccoIn Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. Aim: to assess the T. A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. Series and methods: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. Results: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p = 0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. Conclusion: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAMERP, Med Sch Sao Jose do Rio Preto, Genet & Mol Biol Unit, Sao Jose do Rio Preto, BrazilUNESP Sao Jose do Rio Preto, Sao Jose do Rio Preto, BrazilUNORP Sao Jose do Rio Preto, Sao Jose do Rio Preto, BrazilFAMERP, Med Sch Sao Jose do Rio Preto, Dept Mol Biol, Sao Jose do Rio Preto, BrazilUPGEM, Unidade Pesquisa Genet & Biol Mol, BR-15090000 Sao Jose do Rio Preto, BrazilFAPESP, São Paulo, BrazilCtr Nacl Desenvolvimento Cient & Tecnol CNPq, São Paulo, BrazilUNESP Sao Jose do Rio Preto, Sao Jose do Rio Preto, BrazilAssoc Brasileira Otorrinolaringologia & Cirurgia CervicofacialFaculdade de Medicina de São José do Rio Preto (FAMERP)Universidade Estadual Paulista (Unesp)UNORP São José do Rio PretoUPGEMRuiz, Mariangela TorreglosaBalachi, Janayna Fernanda [UNESP]Fernandes, Raquel AldrighiSilva Galbiatti, Ana LiviaManiglia, Jose VictorPavarino-Bertelli, Erika CristinaGoloni-Bertollo, Eny Maria2014-05-20T15:33:30Z2014-05-20T15:33:30Z2010-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article193-198application/pdfhttp://dx.doi.org/10.1590/S1808-86942010000200008Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 76, n. 2, p. 193-198, 2010.1808-8694http://hdl.handle.net/11449/42106S1808-86942010000200008WOS:000293572100008S1808-86942010000200008.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Otorhinolaryngology1.4120,443info:eu-repo/semantics/openAccess2023-11-09T06:11:28Zoai:repositorio.unesp.br:11449/42106Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-09T06:11:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
spellingShingle |
Analysis of the TAX1BP1 gene in head and neck cancer patients Ruiz, Mariangela Torreglosa Alcohol drinking Genetics Head and neck neoplasms Tobacco |
title_short |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_full |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_fullStr |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_full_unstemmed |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_sort |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
author |
Ruiz, Mariangela Torreglosa |
author_facet |
Ruiz, Mariangela Torreglosa Balachi, Janayna Fernanda [UNESP] Fernandes, Raquel Aldrighi Silva Galbiatti, Ana Livia Maniglia, Jose Victor Pavarino-Bertelli, Erika Cristina Goloni-Bertollo, Eny Maria |
author_role |
author |
author2 |
Balachi, Janayna Fernanda [UNESP] Fernandes, Raquel Aldrighi Silva Galbiatti, Ana Livia Maniglia, Jose Victor Pavarino-Bertelli, Erika Cristina Goloni-Bertollo, Eny Maria |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina de São José do Rio Preto (FAMERP) Universidade Estadual Paulista (Unesp) UNORP São José do Rio Preto UPGEM |
dc.contributor.author.fl_str_mv |
Ruiz, Mariangela Torreglosa Balachi, Janayna Fernanda [UNESP] Fernandes, Raquel Aldrighi Silva Galbiatti, Ana Livia Maniglia, Jose Victor Pavarino-Bertelli, Erika Cristina Goloni-Bertollo, Eny Maria |
dc.subject.por.fl_str_mv |
Alcohol drinking Genetics Head and neck neoplasms Tobacco |
topic |
Alcohol drinking Genetics Head and neck neoplasms Tobacco |
description |
In Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. Aim: to assess the T. A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. Series and methods: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. Results: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p = 0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. Conclusion: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03-01 2014-05-20T15:33:30Z 2014-05-20T15:33:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1808-86942010000200008 Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 76, n. 2, p. 193-198, 2010. 1808-8694 http://hdl.handle.net/11449/42106 S1808-86942010000200008 WOS:000293572100008 S1808-86942010000200008.pdf |
url |
http://dx.doi.org/10.1590/S1808-86942010000200008 http://hdl.handle.net/11449/42106 |
identifier_str_mv |
Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 76, n. 2, p. 193-198, 2010. 1808-8694 S1808-86942010000200008 WOS:000293572100008 S1808-86942010000200008.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology 1.412 0,443 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
193-198 application/pdf |
dc.publisher.none.fl_str_mv |
Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial |
publisher.none.fl_str_mv |
Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964873304571904 |