Evidence of natural Zika virus infection in neotropical non-human primates in Brazil

• Autor(a) principal: Terzian, Ana Carolina B.
• Data de Publicação: 2018
• Outros Autores: Zini, Nathalia, Sacchetto, Lívia, Rocha, Rebeca Froes, Parra, Maisa Carla Pereira, Del Sarto, Juliana Lemos, Dias, Ana Carolina Fialho, Coutinho, Felipe, Rayra, Jéssica, da Silva, Rafael Alves, Costa, Vivian Vasconcelos, Fernandes, Natália Coelho Couto De Azevedo, Réssio, Rodrigo, Díaz-Delgado, Josué, Guerra, Juliana, Cunha, Mariana S., Catão-Dias, José Luiz, Bittar, Cintia [UNESP], Reis, Andréia Francesli Negri, Santos, Izalco Nuremberg Penha dos, Ferreira, Andréia Cristina Marascalchi, Cruz, Lilian Elisa Arão Antônio, Rahal, Paula [UNESP], Ullmann, Leila [UNESP], Malossi, Camila [UNESP], Araújo Jr, João Pessoa de [UNESP], Widen, Steven, de Rezende, Izabela Maurício, Mello, Érica, Pacca, Carolina Colombelli, Kroon, Erna Geessien, Trindade, Giliane, Drumond, Betânia, Chiaravalloti-Neto, Francisco, Vasilakis, Nikos, Teixeira, Mauro M., Nogueira, Maurício Lacerda
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1038/s41598-018-34423-6; http://hdl.handle.net/11449/188275

In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.