Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex

Detalhes bibliográficos
Autor(a) principal: Maturi, Fernando E. [UNESP]
Data de Publicação: 2019
Outros Autores: Sábio, Rafael M., Silva, Robson R., Lahoud, Marcelo G. [UNESP], Meneguin, Andréia B., Valente, Gustavo T., Caface, Raphael A., Leite, Ilaiáli S., Inada, Natalia M., Ribeiro, Sidney J. L. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/ma12060933
http://hdl.handle.net/11449/190232
Resumo: Mesoporous silica nanoparticles prepared by organic template-driven synthesis have been successfully explored as carriers of the drug-derivate green luminescent complex of terbium (III) with the nonsteroidal anti-inflammatory drug ketoprofen. The terbium (III) complex was synthesized by reacting ketoprofen sodium salt with terbium (III) chloride, which was further adsorbed onto the surface of mesoporous nanoparticles with a mean particle size of 47 ± 4 nm and pore size of 11 nm. The incorporation of the complex into mesoporous silica nanoparticles was tracked by the decrease in the surface area and pore size of the nanoparticles, and successfully demonstrated by substantial changes in the adsorption isotherms and thermal and vibrational spectroscopy results. The cytotoxicity assay and confocal microscopy have shown that the novel luminescent nanohybrid presents high cell viability and the characteristic terbium (III) emission can be assessed through two-photon excitation, which paves the way for bioimaging applications in nanomedicine.
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spelling Luminescent mesoporous silica nanohybrid based on drug derivative terbium complexKetoprofenLuminescent nanohybridMesoporous silica nanoparticlesTerbiumTwo-photonMesoporous silica nanoparticles prepared by organic template-driven synthesis have been successfully explored as carriers of the drug-derivate green luminescent complex of terbium (III) with the nonsteroidal anti-inflammatory drug ketoprofen. The terbium (III) complex was synthesized by reacting ketoprofen sodium salt with terbium (III) chloride, which was further adsorbed onto the surface of mesoporous nanoparticles with a mean particle size of 47 ± 4 nm and pore size of 11 nm. The incorporation of the complex into mesoporous silica nanoparticles was tracked by the decrease in the surface area and pore size of the nanoparticles, and successfully demonstrated by substantial changes in the adsorption isotherms and thermal and vibrational spectroscopy results. The cytotoxicity assay and confocal microscopy have shown that the novel luminescent nanohybrid presents high cell viability and the characteristic terbium (III) emission can be assessed through two-photon excitation, which paves the way for bioimaging applications in nanomedicine.Institute of Chemistry São Paulo State University-UNESPSão Carlos Institute of Physics University of São Paulo-USPInstitute of Chemistry São Paulo State University-UNESPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Maturi, Fernando E. [UNESP]Sábio, Rafael M.Silva, Robson R.Lahoud, Marcelo G. [UNESP]Meneguin, Andréia B.Valente, Gustavo T.Caface, Raphael A.Leite, Ilaiáli S.Inada, Natalia M.Ribeiro, Sidney J. L. [UNESP]2019-10-06T17:06:31Z2019-10-06T17:06:31Z2019-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ma12060933Materials, v. 16, n. 6, 2019.1996-1944http://hdl.handle.net/11449/19023210.3390/ma120609332-s2.0-85063543684Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterialsinfo:eu-repo/semantics/openAccess2021-10-23T00:57:26Zoai:repositorio.unesp.br:11449/190232Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T00:57:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex
title Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex
spellingShingle Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex
Maturi, Fernando E. [UNESP]
Ketoprofen
Luminescent nanohybrid
Mesoporous silica nanoparticles
Terbium
Two-photon
title_short Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex
title_full Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex
title_fullStr Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex
title_full_unstemmed Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex
title_sort Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex
author Maturi, Fernando E. [UNESP]
author_facet Maturi, Fernando E. [UNESP]
Sábio, Rafael M.
Silva, Robson R.
Lahoud, Marcelo G. [UNESP]
Meneguin, Andréia B.
Valente, Gustavo T.
Caface, Raphael A.
Leite, Ilaiáli S.
Inada, Natalia M.
Ribeiro, Sidney J. L. [UNESP]
author_role author
author2 Sábio, Rafael M.
Silva, Robson R.
Lahoud, Marcelo G. [UNESP]
Meneguin, Andréia B.
Valente, Gustavo T.
Caface, Raphael A.
Leite, Ilaiáli S.
Inada, Natalia M.
Ribeiro, Sidney J. L. [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Maturi, Fernando E. [UNESP]
Sábio, Rafael M.
Silva, Robson R.
Lahoud, Marcelo G. [UNESP]
Meneguin, Andréia B.
Valente, Gustavo T.
Caface, Raphael A.
Leite, Ilaiáli S.
Inada, Natalia M.
Ribeiro, Sidney J. L. [UNESP]
dc.subject.por.fl_str_mv Ketoprofen
Luminescent nanohybrid
Mesoporous silica nanoparticles
Terbium
Two-photon
topic Ketoprofen
Luminescent nanohybrid
Mesoporous silica nanoparticles
Terbium
Two-photon
description Mesoporous silica nanoparticles prepared by organic template-driven synthesis have been successfully explored as carriers of the drug-derivate green luminescent complex of terbium (III) with the nonsteroidal anti-inflammatory drug ketoprofen. The terbium (III) complex was synthesized by reacting ketoprofen sodium salt with terbium (III) chloride, which was further adsorbed onto the surface of mesoporous nanoparticles with a mean particle size of 47 ± 4 nm and pore size of 11 nm. The incorporation of the complex into mesoporous silica nanoparticles was tracked by the decrease in the surface area and pore size of the nanoparticles, and successfully demonstrated by substantial changes in the adsorption isotherms and thermal and vibrational spectroscopy results. The cytotoxicity assay and confocal microscopy have shown that the novel luminescent nanohybrid presents high cell viability and the characteristic terbium (III) emission can be assessed through two-photon excitation, which paves the way for bioimaging applications in nanomedicine.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T17:06:31Z
2019-10-06T17:06:31Z
2019-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/ma12060933
Materials, v. 16, n. 6, 2019.
1996-1944
http://hdl.handle.net/11449/190232
10.3390/ma12060933
2-s2.0-85063543684
url http://dx.doi.org/10.3390/ma12060933
http://hdl.handle.net/11449/190232
identifier_str_mv Materials, v. 16, n. 6, 2019.
1996-1944
10.3390/ma12060933
2-s2.0-85063543684
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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