Brazilian propolis antileishmanial and immunomodulatory effects
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2013/673058 http://hdl.handle.net/11449/75640 |
Resumo: | The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morphologic alterations observed by scanning electron microscopy. In in vitro immunomodulatory assays, macrophages were pretreated with propolis and then infected with L. (V.) braziliensis. In vivo, supernatants from liver cells and peritoneal exudate of BALB/c mice pretreated with propolis and infected with Leishmania (107/mL promastigotes) were collected, and TNF- α and IL-12 were measured by ELISA. Macrophages incubated with propolis showed a significant increase in interiorization and further killing of parasites. An increased TNF- α production was seen in mice pretreated with propolis, whereas IL-12 was downregulated during the infection. In conclusion, Brazilian propolis showed a direct action on the parasite and displayed immunomodulatory effects on murine macrophages, even though the parasite has been reported to affect the activation pathways of the cell. The observed effects could be associated with the presence of phenolic compounds (flavonoids, aromatic acids, and benzopyranes), di- and triterpenes, and essential oils found in our propolis sample. © 2013 Suelen Santos da Silva et al. |
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Brazilian propolis antileishmanial and immunomodulatory effectsantileishmanial agentimmunomodulating agentinterleukin 12propolistumor necrosis factor alphaanimal experimentanimal modelBrazilcontrolled studycytokine productiondown regulationimmunomodulationin vitro studyinfectious disease ELISA kitLeishmania braziliensisleishmaniasismacrophagemalemousenonhumanpriority journalscanning electron microscopyThe antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morphologic alterations observed by scanning electron microscopy. In in vitro immunomodulatory assays, macrophages were pretreated with propolis and then infected with L. (V.) braziliensis. In vivo, supernatants from liver cells and peritoneal exudate of BALB/c mice pretreated with propolis and infected with Leishmania (107/mL promastigotes) were collected, and TNF- α and IL-12 were measured by ELISA. Macrophages incubated with propolis showed a significant increase in interiorization and further killing of parasites. An increased TNF- α production was seen in mice pretreated with propolis, whereas IL-12 was downregulated during the infection. In conclusion, Brazilian propolis showed a direct action on the parasite and displayed immunomodulatory effects on murine macrophages, even though the parasite has been reported to affect the activation pathways of the cell. The observed effects could be associated with the presence of phenolic compounds (flavonoids, aromatic acids, and benzopyranes), di- and triterpenes, and essential oils found in our propolis sample. © 2013 Suelen Santos da Silva et al.Department of Science Pathology Londrina State University (UEL), 86057-970 Londrina, PRDepartment of General Biology Laboratory of Electron Microscopy and Microanalysis Londrina State University (UEL), 86057-970 Londrina, PRDepartment of Microbiology and Immunology Biosciences Institute (UNESP), 18618-970 Botucatu, SPDepartment of Microbiology and Immunology Biosciences Institute (UNESP), 18618-970 Botucatu, SPUniversidade Estadual de Londrina (UEL)Universidade Estadual Paulista (Unesp)Da Silva, Suelen SantosThomé, Graciele Da SilvaCataneo, Allan Henrique DepieriMiranda, Milena MenegazzoFelipe, IoniceAndrade, Célia Guadalupe Tardeli de JesusWatanabe, Maria Angélica EharaPiana, Gilce Maria [UNESP]Sforcin, José Maurício [UNESP]Pavanelli, Wander RogérioConchon-Costa, Ivete2014-05-27T11:29:40Z2014-05-27T11:29:40Z2013-06-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2013/673058Evidence-based Complementary and Alternative Medicine, v. 2013.1741-427X1741-4288http://hdl.handle.net/11449/7564010.1155/2013/673058WOS:0003195786000012-s2.0-848786958032-s2.0-84878695803.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary and Alternative Medicine2.0640,683info:eu-repo/semantics/openAccess2023-11-12T06:15:38Zoai:repositorio.unesp.br:11449/75640Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:31:09.634223Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Brazilian propolis antileishmanial and immunomodulatory effects |
title |
Brazilian propolis antileishmanial and immunomodulatory effects |
spellingShingle |
Brazilian propolis antileishmanial and immunomodulatory effects Da Silva, Suelen Santos antileishmanial agent immunomodulating agent interleukin 12 propolis tumor necrosis factor alpha animal experiment animal model Brazil controlled study cytokine production down regulation immunomodulation in vitro study infectious disease ELISA kit Leishmania braziliensis leishmaniasis macrophage male mouse nonhuman priority journal scanning electron microscopy |
title_short |
Brazilian propolis antileishmanial and immunomodulatory effects |
title_full |
Brazilian propolis antileishmanial and immunomodulatory effects |
title_fullStr |
Brazilian propolis antileishmanial and immunomodulatory effects |
title_full_unstemmed |
Brazilian propolis antileishmanial and immunomodulatory effects |
title_sort |
Brazilian propolis antileishmanial and immunomodulatory effects |
author |
Da Silva, Suelen Santos |
author_facet |
Da Silva, Suelen Santos Thomé, Graciele Da Silva Cataneo, Allan Henrique Depieri Miranda, Milena Menegazzo Felipe, Ionice Andrade, Célia Guadalupe Tardeli de Jesus Watanabe, Maria Angélica Ehara Piana, Gilce Maria [UNESP] Sforcin, José Maurício [UNESP] Pavanelli, Wander Rogério Conchon-Costa, Ivete |
author_role |
author |
author2 |
Thomé, Graciele Da Silva Cataneo, Allan Henrique Depieri Miranda, Milena Menegazzo Felipe, Ionice Andrade, Célia Guadalupe Tardeli de Jesus Watanabe, Maria Angélica Ehara Piana, Gilce Maria [UNESP] Sforcin, José Maurício [UNESP] Pavanelli, Wander Rogério Conchon-Costa, Ivete |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Da Silva, Suelen Santos Thomé, Graciele Da Silva Cataneo, Allan Henrique Depieri Miranda, Milena Menegazzo Felipe, Ionice Andrade, Célia Guadalupe Tardeli de Jesus Watanabe, Maria Angélica Ehara Piana, Gilce Maria [UNESP] Sforcin, José Maurício [UNESP] Pavanelli, Wander Rogério Conchon-Costa, Ivete |
dc.subject.por.fl_str_mv |
antileishmanial agent immunomodulating agent interleukin 12 propolis tumor necrosis factor alpha animal experiment animal model Brazil controlled study cytokine production down regulation immunomodulation in vitro study infectious disease ELISA kit Leishmania braziliensis leishmaniasis macrophage male mouse nonhuman priority journal scanning electron microscopy |
topic |
antileishmanial agent immunomodulating agent interleukin 12 propolis tumor necrosis factor alpha animal experiment animal model Brazil controlled study cytokine production down regulation immunomodulation in vitro study infectious disease ELISA kit Leishmania braziliensis leishmaniasis macrophage male mouse nonhuman priority journal scanning electron microscopy |
description |
The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morphologic alterations observed by scanning electron microscopy. In in vitro immunomodulatory assays, macrophages were pretreated with propolis and then infected with L. (V.) braziliensis. In vivo, supernatants from liver cells and peritoneal exudate of BALB/c mice pretreated with propolis and infected with Leishmania (107/mL promastigotes) were collected, and TNF- α and IL-12 were measured by ELISA. Macrophages incubated with propolis showed a significant increase in interiorization and further killing of parasites. An increased TNF- α production was seen in mice pretreated with propolis, whereas IL-12 was downregulated during the infection. In conclusion, Brazilian propolis showed a direct action on the parasite and displayed immunomodulatory effects on murine macrophages, even though the parasite has been reported to affect the activation pathways of the cell. The observed effects could be associated with the presence of phenolic compounds (flavonoids, aromatic acids, and benzopyranes), di- and triterpenes, and essential oils found in our propolis sample. © 2013 Suelen Santos da Silva et al. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-12 2014-05-27T11:29:40Z 2014-05-27T11:29:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2013/673058 Evidence-based Complementary and Alternative Medicine, v. 2013. 1741-427X 1741-4288 http://hdl.handle.net/11449/75640 10.1155/2013/673058 WOS:000319578600001 2-s2.0-84878695803 2-s2.0-84878695803.pdf |
url |
http://dx.doi.org/10.1155/2013/673058 http://hdl.handle.net/11449/75640 |
identifier_str_mv |
Evidence-based Complementary and Alternative Medicine, v. 2013. 1741-427X 1741-4288 10.1155/2013/673058 WOS:000319578600001 2-s2.0-84878695803 2-s2.0-84878695803.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evidence-based Complementary and Alternative Medicine 2.064 0,683 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128820630257664 |