CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/197289 |
Resumo: | The authors give a general overview on the cerebral glucose metabolism, with special reference to brain injury, including intake, blood-brain barrier properties for glucose transport, oxidative metabolism and energetic needs during the head trauma. The evidences of the presence of ischemia and hypoxia in those situations and the relationships with the cerebral glucose metabolism are discussed. They point to the several explanations for hyperglicemia present up to 10 days after admission in brain injury, relating to the energetic needs at different phases of head trauma recovery. Some considerations are made about the lack of evidences on increase in glucose consumption or lactate production when hyperglycemia occurs in association with brain damage and ischemia caused by head trauma. The brain capacity to compensate metabolic disturbances is discussed. Some questions are made about current indications for restriction of glucose infusion in pacients who are in catabolic phase and need to spare their body protein pool. At the same way, the polemic about previous hyperglycemia and cerebral injury is revised. Some considerations are made about the moment to introduct increases in glucose administration. |
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Repositório Institucional da UNESP |
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CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEWGLUCOSECEREBRAL METABOLISMHYPERGLYCEMIAHEAD INJURYThe authors give a general overview on the cerebral glucose metabolism, with special reference to brain injury, including intake, blood-brain barrier properties for glucose transport, oxidative metabolism and energetic needs during the head trauma. The evidences of the presence of ischemia and hypoxia in those situations and the relationships with the cerebral glucose metabolism are discussed. They point to the several explanations for hyperglicemia present up to 10 days after admission in brain injury, relating to the energetic needs at different phases of head trauma recovery. Some considerations are made about the lack of evidences on increase in glucose consumption or lactate production when hyperglycemia occurs in association with brain damage and ischemia caused by head trauma. The brain capacity to compensate metabolic disturbances is discussed. Some questions are made about current indications for restriction of glucose infusion in pacients who are in catabolic phase and need to spare their body protein pool. At the same way, the polemic about previous hyperglycemia and cerebral injury is revised. Some considerations are made about the moment to introduct increases in glucose administration.UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, FAC MED BOTUCATU, DEPT NEUROL & PSIQUIATRIA, BR-18618000 BOTUCATU, SP, BRAZILUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, FAC MED BOTUCATU, POSGRAD CURSO PATOL, BR-18618000 BOTUCATU, SP, BRAZILUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, FAC MED BOTUCATU, DEPT CLIN MED, BR-18618000 BOTUCATU, SP, BRAZILUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, FAC MED BOTUCATU, DEPT NEUROL & PSIQUIATRIA, BR-18618000 BOTUCATU, SP, BRAZILUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, FAC MED BOTUCATU, POSGRAD CURSO PATOL, BR-18618000 BOTUCATU, SP, BRAZILUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, FAC MED BOTUCATU, DEPT CLIN MED, BR-18618000 BOTUCATU, SP, BRAZILAssoc Arquivos Neuro- PsiquiatriaUniversidade Estadual Paulista (Unesp)Avaliacao, U.2020-12-10T20:12:15Z2020-12-10T20:12:15Z1995-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article698-705Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos Neuro- Psiquiatria, v. 53, n. 3B, p. 698-705, 1995.0004-282Xhttp://hdl.handle.net/11449/197289WOS:A1995TB69900026Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos De Neuro-psiquiatriainfo:eu-repo/semantics/openAccess2024-09-03T13:14:41Zoai:repositorio.unesp.br:11449/197289Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW |
title |
CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW |
spellingShingle |
CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW Avaliacao, U. GLUCOSE CEREBRAL METABOLISM HYPERGLYCEMIA HEAD INJURY |
title_short |
CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW |
title_full |
CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW |
title_fullStr |
CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW |
title_full_unstemmed |
CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW |
title_sort |
CEREBRAL GLUCOSE-METABOLISM AND HEAD-INJURY - AN OVERVIEW |
author |
Avaliacao, U. |
author_facet |
Avaliacao, U. |
author_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Avaliacao, U. |
dc.subject.por.fl_str_mv |
GLUCOSE CEREBRAL METABOLISM HYPERGLYCEMIA HEAD INJURY |
topic |
GLUCOSE CEREBRAL METABOLISM HYPERGLYCEMIA HEAD INJURY |
description |
The authors give a general overview on the cerebral glucose metabolism, with special reference to brain injury, including intake, blood-brain barrier properties for glucose transport, oxidative metabolism and energetic needs during the head trauma. The evidences of the presence of ischemia and hypoxia in those situations and the relationships with the cerebral glucose metabolism are discussed. They point to the several explanations for hyperglicemia present up to 10 days after admission in brain injury, relating to the energetic needs at different phases of head trauma recovery. Some considerations are made about the lack of evidences on increase in glucose consumption or lactate production when hyperglycemia occurs in association with brain damage and ischemia caused by head trauma. The brain capacity to compensate metabolic disturbances is discussed. Some questions are made about current indications for restriction of glucose infusion in pacients who are in catabolic phase and need to spare their body protein pool. At the same way, the polemic about previous hyperglycemia and cerebral injury is revised. Some considerations are made about the moment to introduct increases in glucose administration. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-09-01 2020-12-10T20:12:15Z 2020-12-10T20:12:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos Neuro- Psiquiatria, v. 53, n. 3B, p. 698-705, 1995. 0004-282X http://hdl.handle.net/11449/197289 WOS:A1995TB69900026 |
identifier_str_mv |
Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos Neuro- Psiquiatria, v. 53, n. 3B, p. 698-705, 1995. 0004-282X WOS:A1995TB69900026 |
url |
http://hdl.handle.net/11449/197289 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos De Neuro-psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
698-705 |
dc.publisher.none.fl_str_mv |
Assoc Arquivos Neuro- Psiquiatria |
publisher.none.fl_str_mv |
Assoc Arquivos Neuro- Psiquiatria |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021369992183808 |