Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours

Detalhes bibliográficos
Autor(a) principal: Vargas, T. H. M.
Data de Publicação: 2015
Outros Autores: Pulz, L. H., Barra, C. N., Kleeb, S. R., Xavier, J. G. [UNESP], Catao-Dias, J. L., Fukumasu, H., Nishiya, A. T., Strefezzi, R. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.jcpa.2015.08.010
http://hdl.handle.net/11449/158629
Resumo: Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT. (C) 2015 Elsevier Ltd. All rights reserved.
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spelling Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumourscancer stem celldogmast cell tumourOCT4 proteinCancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT. (C) 2015 Elsevier Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Lab Oncol Comparada & Translac, Sao Paulo, BrazilUniv Sao Paulo, Fac Med Vet & Zootecnia, Sao Paulo, BrazilUniv Metodista Sao Paulo, Sao Bernardo Do Campo, BrazilUniv Estadual Paulista, Sao Paulo, BrazilUniv Anhembi Morumbi, Sao Paulo, BrazilUniv Estadual Paulista, Sao Paulo, BrazilFAPESP: 2010/05094-5FAPESP: 2013/13252-8Elsevier B.V.Universidade de São Paulo (USP)Univ Metodista Sao PauloUniversidade Estadual Paulista (Unesp)Univ Anhembi MorumbiVargas, T. H. M.Pulz, L. H.Barra, C. N.Kleeb, S. R.Xavier, J. G. [UNESP]Catao-Dias, J. L.Fukumasu, H.Nishiya, A. T.Strefezzi, R. F.2018-11-26T15:28:23Z2018-11-26T15:28:23Z2015-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article251-255application/pdfhttp://dx.doi.org/10.1016/j.jcpa.2015.08.010Journal Of Comparative Pathology. Oxford: Elsevier Sci Ltd, v. 153, n. 4, p. 251-255, 2015.0021-9975http://hdl.handle.net/11449/15862910.1016/j.jcpa.2015.08.010WOS:000366883300008WOS000366883300008.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Comparative Pathology0,594info:eu-repo/semantics/openAccess2024-01-27T06:56:18Zoai:repositorio.unesp.br:11449/158629Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:05:02.201176Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours
title Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours
spellingShingle Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours
Vargas, T. H. M.
cancer stem cell
dog
mast cell tumour
OCT4 protein
title_short Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours
title_full Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours
title_fullStr Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours
title_full_unstemmed Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours
title_sort Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours
author Vargas, T. H. M.
author_facet Vargas, T. H. M.
Pulz, L. H.
Barra, C. N.
Kleeb, S. R.
Xavier, J. G. [UNESP]
Catao-Dias, J. L.
Fukumasu, H.
Nishiya, A. T.
Strefezzi, R. F.
author_role author
author2 Pulz, L. H.
Barra, C. N.
Kleeb, S. R.
Xavier, J. G. [UNESP]
Catao-Dias, J. L.
Fukumasu, H.
Nishiya, A. T.
Strefezzi, R. F.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Univ Metodista Sao Paulo
Universidade Estadual Paulista (Unesp)
Univ Anhembi Morumbi
dc.contributor.author.fl_str_mv Vargas, T. H. M.
Pulz, L. H.
Barra, C. N.
Kleeb, S. R.
Xavier, J. G. [UNESP]
Catao-Dias, J. L.
Fukumasu, H.
Nishiya, A. T.
Strefezzi, R. F.
dc.subject.por.fl_str_mv cancer stem cell
dog
mast cell tumour
OCT4 protein
topic cancer stem cell
dog
mast cell tumour
OCT4 protein
description Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT. (C) 2015 Elsevier Ltd. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-01
2018-11-26T15:28:23Z
2018-11-26T15:28:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.jcpa.2015.08.010
Journal Of Comparative Pathology. Oxford: Elsevier Sci Ltd, v. 153, n. 4, p. 251-255, 2015.
0021-9975
http://hdl.handle.net/11449/158629
10.1016/j.jcpa.2015.08.010
WOS:000366883300008
WOS000366883300008.pdf
url http://dx.doi.org/10.1016/j.jcpa.2015.08.010
http://hdl.handle.net/11449/158629
identifier_str_mv Journal Of Comparative Pathology. Oxford: Elsevier Sci Ltd, v. 153, n. 4, p. 251-255, 2015.
0021-9975
10.1016/j.jcpa.2015.08.010
WOS:000366883300008
WOS000366883300008.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Comparative Pathology
0,594
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 251-255
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129581366902784

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