Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.appet.2018.11.012 http://hdl.handle.net/11449/189927 |
Resumo: | Excessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension and spontaneously hypertensive rats (SHR) have a typical increased sodium preference. Estrogens reduce sodium appetite, but we do not know whether such effect relates to alterations in sodium palatability. Here we evaluated the influence of ovarian hormones on orofacial motor responses, an index of palatability, to intra-oral infusion of 0.3 M NaCl (IO–NaCl). Adult female SHR and normotensive Holtzman rats (HTZ) were used. Sodium appetite was produced by water deprivation followed immediately by partial rehydration by drinking water to satiation (WD-PR protocol). Immediately at the end of WD-PR, animals received an IO-NaCl for videotape recording of orofacial motor responses. At the end of IO-NaCl, they had access to two bottles containing 0.3 M NaCl and water to ingest (sodium appetite test). Bilateral ovariectomy (OVX) enhanced 0.3 M NaCl intake during the sodium appetite test and increased the frequency of orofacial hedonic responses to IO-NaCl in both strains. It had no effect on aversive responses. Estradiol treatment in SHR-OVX decreased hedonic responses and increased aversive responses to IO-NaCl. It also reduced 0.3 M NaCl intake during the sodium appetite test, but had no effect on baseline mean arterial pressure and heart rate. The results suggest that ovarian hormones restrain WD-PR-induced sodium appetite by reducing the hedonic properties of sodium taste. The results also suggest that estrogens mediate such reduction, particularly in SHR. |
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Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetiteDehydrationHypertensionRewardSodium appetiteTasteWater deprivationExcessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension and spontaneously hypertensive rats (SHR) have a typical increased sodium preference. Estrogens reduce sodium appetite, but we do not know whether such effect relates to alterations in sodium palatability. Here we evaluated the influence of ovarian hormones on orofacial motor responses, an index of palatability, to intra-oral infusion of 0.3 M NaCl (IO–NaCl). Adult female SHR and normotensive Holtzman rats (HTZ) were used. Sodium appetite was produced by water deprivation followed immediately by partial rehydration by drinking water to satiation (WD-PR protocol). Immediately at the end of WD-PR, animals received an IO-NaCl for videotape recording of orofacial motor responses. At the end of IO-NaCl, they had access to two bottles containing 0.3 M NaCl and water to ingest (sodium appetite test). Bilateral ovariectomy (OVX) enhanced 0.3 M NaCl intake during the sodium appetite test and increased the frequency of orofacial hedonic responses to IO-NaCl in both strains. It had no effect on aversive responses. Estradiol treatment in SHR-OVX decreased hedonic responses and increased aversive responses to IO-NaCl. It also reduced 0.3 M NaCl intake during the sodium appetite test, but had no effect on baseline mean arterial pressure and heart rate. The results suggest that ovarian hormones restrain WD-PR-induced sodium appetite by reducing the hedonic properties of sodium taste. The results also suggest that estrogens mediate such reduction, particularly in SHR.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual PaulistaDepartment of Physiology and Pathology School of Dentistry UNESP – São Paulo State UniversityDepartment of Physiology and Pathology School of Dentistry UNESP – São Paulo State UniversityFAPESP: 2015/20500-3CNPq: 478960/2013-1Universidade Estadual Paulista (Unesp)Pereira, E. D. [UNESP]Dantas, R. M. [UNESP]Andrade-Franzé, G. M.F. [UNESP]De Luca, L. A. [UNESP]Menani, J. V. [UNESP]Andrade, C. A.F. [UNESP]2019-10-06T16:56:47Z2019-10-06T16:56:47Z2019-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article252-261http://dx.doi.org/10.1016/j.appet.2018.11.012Appetite, v. 133, p. 252-261.1095-83040195-6663http://hdl.handle.net/11449/18992710.1016/j.appet.2018.11.0122-s2.0-85057346916Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAppetiteinfo:eu-repo/semantics/openAccess2021-10-23T15:55:12Zoai:repositorio.unesp.br:11449/189927Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:36:02.338406Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite |
title |
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite |
spellingShingle |
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite Pereira, E. D. [UNESP] Dehydration Hypertension Reward Sodium appetite Taste Water deprivation |
title_short |
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite |
title_full |
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite |
title_fullStr |
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite |
title_full_unstemmed |
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite |
title_sort |
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite |
author |
Pereira, E. D. [UNESP] |
author_facet |
Pereira, E. D. [UNESP] Dantas, R. M. [UNESP] Andrade-Franzé, G. M.F. [UNESP] De Luca, L. A. [UNESP] Menani, J. V. [UNESP] Andrade, C. A.F. [UNESP] |
author_role |
author |
author2 |
Dantas, R. M. [UNESP] Andrade-Franzé, G. M.F. [UNESP] De Luca, L. A. [UNESP] Menani, J. V. [UNESP] Andrade, C. A.F. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pereira, E. D. [UNESP] Dantas, R. M. [UNESP] Andrade-Franzé, G. M.F. [UNESP] De Luca, L. A. [UNESP] Menani, J. V. [UNESP] Andrade, C. A.F. [UNESP] |
dc.subject.por.fl_str_mv |
Dehydration Hypertension Reward Sodium appetite Taste Water deprivation |
topic |
Dehydration Hypertension Reward Sodium appetite Taste Water deprivation |
description |
Excessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension and spontaneously hypertensive rats (SHR) have a typical increased sodium preference. Estrogens reduce sodium appetite, but we do not know whether such effect relates to alterations in sodium palatability. Here we evaluated the influence of ovarian hormones on orofacial motor responses, an index of palatability, to intra-oral infusion of 0.3 M NaCl (IO–NaCl). Adult female SHR and normotensive Holtzman rats (HTZ) were used. Sodium appetite was produced by water deprivation followed immediately by partial rehydration by drinking water to satiation (WD-PR protocol). Immediately at the end of WD-PR, animals received an IO-NaCl for videotape recording of orofacial motor responses. At the end of IO-NaCl, they had access to two bottles containing 0.3 M NaCl and water to ingest (sodium appetite test). Bilateral ovariectomy (OVX) enhanced 0.3 M NaCl intake during the sodium appetite test and increased the frequency of orofacial hedonic responses to IO-NaCl in both strains. It had no effect on aversive responses. Estradiol treatment in SHR-OVX decreased hedonic responses and increased aversive responses to IO-NaCl. It also reduced 0.3 M NaCl intake during the sodium appetite test, but had no effect on baseline mean arterial pressure and heart rate. The results suggest that ovarian hormones restrain WD-PR-induced sodium appetite by reducing the hedonic properties of sodium taste. The results also suggest that estrogens mediate such reduction, particularly in SHR. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:56:47Z 2019-10-06T16:56:47Z 2019-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.appet.2018.11.012 Appetite, v. 133, p. 252-261. 1095-8304 0195-6663 http://hdl.handle.net/11449/189927 10.1016/j.appet.2018.11.012 2-s2.0-85057346916 |
url |
http://dx.doi.org/10.1016/j.appet.2018.11.012 http://hdl.handle.net/11449/189927 |
identifier_str_mv |
Appetite, v. 133, p. 252-261. 1095-8304 0195-6663 10.1016/j.appet.2018.11.012 2-s2.0-85057346916 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Appetite |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
252-261 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129535284084736 |