Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jevs.2020.102989 http://hdl.handle.net/11449/200221 |
Resumo: | The acute phase response is a response to injury and depends on the severity of the trauma. Heparin is routinely used for postsurgical treatment of horses to prevent abdominal adhesions; however, its effect on inflammation is unknown. This study aimed to assess systemic inflammatory response of horses subjected to small colon enterotomy and to evaluate heparin effects on postsurgical inflammation. Ten adult horses were subjected to small colon enterotomy and were assigned to a control or a treatment group. Both groups received prophylactic antibiotics and flunixin, and the treatment group received 150 IU/kg heparin subcutaneously after surgery and every 12 hours for five days. WBC counts, peritoneal fluid evaluation, determination of serum and peritoneal haptoglobin (Hp), and serum amyloid A (SAA) were performed before, 12 hours, and 1, 2, 4, 6, 10, and 14 days after enterotomy. Forty-eight hours after surgery, a significant increase in serum Hp was observed in the control group, and SAA concentrations increased significantly in the both groups between 24 hours, 48 hours, and 4 days after surgery. The SAA and serum Hp concentrations produced no significant differences between the groups. Peritoneal Hp increased significantly in the control group 4 days after surgery and was significantly higher in the control group than in the treated group 14 days after surgery. Serum Hp and SAA identified the acute phase response changes faster, however, were not able to identify differences between groups. Peritoneal Hp concentrations identified inflammatory differences between the groups 14 days after surgery; the difference suggests that heparin may act decreasing inflammation. |
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Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With HeparinAcute phase responseHaptoglobinHorseInflammation serum amyloid AThe acute phase response is a response to injury and depends on the severity of the trauma. Heparin is routinely used for postsurgical treatment of horses to prevent abdominal adhesions; however, its effect on inflammation is unknown. This study aimed to assess systemic inflammatory response of horses subjected to small colon enterotomy and to evaluate heparin effects on postsurgical inflammation. Ten adult horses were subjected to small colon enterotomy and were assigned to a control or a treatment group. Both groups received prophylactic antibiotics and flunixin, and the treatment group received 150 IU/kg heparin subcutaneously after surgery and every 12 hours for five days. WBC counts, peritoneal fluid evaluation, determination of serum and peritoneal haptoglobin (Hp), and serum amyloid A (SAA) were performed before, 12 hours, and 1, 2, 4, 6, 10, and 14 days after enterotomy. Forty-eight hours after surgery, a significant increase in serum Hp was observed in the control group, and SAA concentrations increased significantly in the both groups between 24 hours, 48 hours, and 4 days after surgery. The SAA and serum Hp concentrations produced no significant differences between the groups. Peritoneal Hp increased significantly in the control group 4 days after surgery and was significantly higher in the control group than in the treated group 14 days after surgery. Serum Hp and SAA identified the acute phase response changes faster, however, were not able to identify differences between groups. Peritoneal Hp concentrations identified inflammatory differences between the groups 14 days after surgery; the difference suggests that heparin may act decreasing inflammation.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Anesthesiology and Veterinary Surgery School of Veterinary Medicine and Animal Science São Paulo State University (UNESP) Campus of BotucatuDepartment of Veterinary Clinical Sciences School of Veterinary Medicine and Animal Science São Paulo State University (UNESP) Campus of BotucatuInstitute of Biodiversity Animal Health and Comparative Medicine College of Medical Veterinary and Life Sciences University of GlasgowFaculty of Health and Medical Sciences Department of Veterinary Clinical Sciences University of CopenhagenDepartment of Anesthesiology and Veterinary Surgery School of Veterinary Medicine and Animal Science São Paulo State University (UNESP) Campus of BotucatuDepartment of Veterinary Clinical Sciences School of Veterinary Medicine and Animal Science São Paulo State University (UNESP) Campus of BotucatuFAPESP: # 2011/23359-9Universidade Estadual Paulista (Unesp)University of GlasgowUniversity of CopenhagenAlonso, Juliana de M. [UNESP]Schmidt, Elizabeth M.S. [UNESP]Eckersall, Peter D.Kjelgaard-Hansen, MadsAlves, Ana Liz G. [UNESP]Rodrigues, Celso A. [UNESP]Watanabe, Marcos J. [UNESP]Crescencio, Amanda P. [UNESP]Hussni, Carlos A. [UNESP]2020-12-12T02:00:50Z2020-12-12T02:00:50Z2020-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jevs.2020.102989Journal of Equine Veterinary Science, v. 90.0737-0806http://hdl.handle.net/11449/20022110.1016/j.jevs.2020.1029892-s2.0-85082555401Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Equine Veterinary Scienceinfo:eu-repo/semantics/openAccess2021-10-23T12:31:35Zoai:repositorio.unesp.br:11449/200221Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T12:31:35Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin |
title |
Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin |
spellingShingle |
Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin Alonso, Juliana de M. [UNESP] Acute phase response Haptoglobin Horse Inflammation serum amyloid A |
title_short |
Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin |
title_full |
Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin |
title_fullStr |
Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin |
title_full_unstemmed |
Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin |
title_sort |
Inflammatory Response of Healthy Horses Subjected to Small Colon Enterotomy and Treated or Not With Heparin |
author |
Alonso, Juliana de M. [UNESP] |
author_facet |
Alonso, Juliana de M. [UNESP] Schmidt, Elizabeth M.S. [UNESP] Eckersall, Peter D. Kjelgaard-Hansen, Mads Alves, Ana Liz G. [UNESP] Rodrigues, Celso A. [UNESP] Watanabe, Marcos J. [UNESP] Crescencio, Amanda P. [UNESP] Hussni, Carlos A. [UNESP] |
author_role |
author |
author2 |
Schmidt, Elizabeth M.S. [UNESP] Eckersall, Peter D. Kjelgaard-Hansen, Mads Alves, Ana Liz G. [UNESP] Rodrigues, Celso A. [UNESP] Watanabe, Marcos J. [UNESP] Crescencio, Amanda P. [UNESP] Hussni, Carlos A. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Glasgow University of Copenhagen |
dc.contributor.author.fl_str_mv |
Alonso, Juliana de M. [UNESP] Schmidt, Elizabeth M.S. [UNESP] Eckersall, Peter D. Kjelgaard-Hansen, Mads Alves, Ana Liz G. [UNESP] Rodrigues, Celso A. [UNESP] Watanabe, Marcos J. [UNESP] Crescencio, Amanda P. [UNESP] Hussni, Carlos A. [UNESP] |
dc.subject.por.fl_str_mv |
Acute phase response Haptoglobin Horse Inflammation serum amyloid A |
topic |
Acute phase response Haptoglobin Horse Inflammation serum amyloid A |
description |
The acute phase response is a response to injury and depends on the severity of the trauma. Heparin is routinely used for postsurgical treatment of horses to prevent abdominal adhesions; however, its effect on inflammation is unknown. This study aimed to assess systemic inflammatory response of horses subjected to small colon enterotomy and to evaluate heparin effects on postsurgical inflammation. Ten adult horses were subjected to small colon enterotomy and were assigned to a control or a treatment group. Both groups received prophylactic antibiotics and flunixin, and the treatment group received 150 IU/kg heparin subcutaneously after surgery and every 12 hours for five days. WBC counts, peritoneal fluid evaluation, determination of serum and peritoneal haptoglobin (Hp), and serum amyloid A (SAA) were performed before, 12 hours, and 1, 2, 4, 6, 10, and 14 days after enterotomy. Forty-eight hours after surgery, a significant increase in serum Hp was observed in the control group, and SAA concentrations increased significantly in the both groups between 24 hours, 48 hours, and 4 days after surgery. The SAA and serum Hp concentrations produced no significant differences between the groups. Peritoneal Hp increased significantly in the control group 4 days after surgery and was significantly higher in the control group than in the treated group 14 days after surgery. Serum Hp and SAA identified the acute phase response changes faster, however, were not able to identify differences between groups. Peritoneal Hp concentrations identified inflammatory differences between the groups 14 days after surgery; the difference suggests that heparin may act decreasing inflammation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:00:50Z 2020-12-12T02:00:50Z 2020-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jevs.2020.102989 Journal of Equine Veterinary Science, v. 90. 0737-0806 http://hdl.handle.net/11449/200221 10.1016/j.jevs.2020.102989 2-s2.0-85082555401 |
url |
http://dx.doi.org/10.1016/j.jevs.2020.102989 http://hdl.handle.net/11449/200221 |
identifier_str_mv |
Journal of Equine Veterinary Science, v. 90. 0737-0806 10.1016/j.jevs.2020.102989 2-s2.0-85082555401 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Equine Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799964708667654144 |