Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ajoms.2016.05.015 http://hdl.handle.net/11449/178384 |
Resumo: | Objective Despite the advances in medicine, the oral squamous cell carcinomas still have high incidence and are very important to study topics such as their lymphatic and microvessel density. This research assessed the correlation between histological grading, formation of new lymphatic and blood vessels and cell proliferation in squamous cell carcinomas (SCC). Methods Twenty-nine oral floor SCC and 30 tongue cases were assessed for their clinical characteristics and histological grading of malignancy. Results The presence of VEGF (vascular endothelial growth factor VG1), VEGF-C (vascular endothelial growth factor-C), CD105, to determine blood microvascular (MVD), and D2-40 to determine lymphatic density (LMD) was investigated using immunohistochemistry. Histological grading revealed that 73.3% of tongue and 96.67% of floor cases were classified as highly aggressive. Cell proliferation was greater on the floor; however, no significant difference was observed. Most carcinomas were VEGF negative (tongue 63.3% and floor 70.0%) and VEGF-C positive (tongue 73.3% and floor 79.3%). LMD was considerably greater on the tongue. High MVD values occurred in cases with greater cell proliferation. No relationship was determined between the growth factors VEGF and VEGF-C and MVD and LMD, respectively. Conclusion Floor of mouth SCC cases was morphologically more aggressive than tongue cases; however, in tongue carcinomas a greater quantity of lymphatic vessels could represent potential ways for locoregional cell dissemination of the neoplastic cells, independent of histological grading. Blood vascularization presented correlation with cell proliferation in intraoral squamous cell carcinoma and could be useful in the prognostic assessment of this neoplasm. |
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Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinomaCD105D2-40Ki-67Oral cancerSquamous cell cancerObjective Despite the advances in medicine, the oral squamous cell carcinomas still have high incidence and are very important to study topics such as their lymphatic and microvessel density. This research assessed the correlation between histological grading, formation of new lymphatic and blood vessels and cell proliferation in squamous cell carcinomas (SCC). Methods Twenty-nine oral floor SCC and 30 tongue cases were assessed for their clinical characteristics and histological grading of malignancy. Results The presence of VEGF (vascular endothelial growth factor VG1), VEGF-C (vascular endothelial growth factor-C), CD105, to determine blood microvascular (MVD), and D2-40 to determine lymphatic density (LMD) was investigated using immunohistochemistry. Histological grading revealed that 73.3% of tongue and 96.67% of floor cases were classified as highly aggressive. Cell proliferation was greater on the floor; however, no significant difference was observed. Most carcinomas were VEGF negative (tongue 63.3% and floor 70.0%) and VEGF-C positive (tongue 73.3% and floor 79.3%). LMD was considerably greater on the tongue. High MVD values occurred in cases with greater cell proliferation. No relationship was determined between the growth factors VEGF and VEGF-C and MVD and LMD, respectively. Conclusion Floor of mouth SCC cases was morphologically more aggressive than tongue cases; however, in tongue carcinomas a greater quantity of lymphatic vessels could represent potential ways for locoregional cell dissemination of the neoplastic cells, independent of histological grading. Blood vascularization presented correlation with cell proliferation in intraoral squamous cell carcinoma and could be useful in the prognostic assessment of this neoplasm.Department of Bioscience and Oral Diagnosis Institute of Science and Technology Univ Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777Faculdade de Medicina Universidade de Santo Amaro – UNISA, Rua Professor Enéas de Siqueira Neto, 340Department of Bioscience and Oral Diagnosis Institute of Science and Technology Univ Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777Universidade Estadual Paulista (Unesp)Universidade de Santo Amaro – UNISABertini, Fernanda [UNESP]do Prado, Renata Falchete [UNESP]de Oliveira, Aline Júnia [UNESP]Tera, Tábata de Melo [UNESP]Rosa, Luiz Eduardo Blumer [UNESP]Seabra, Julia CarvalhoCarvalho, Yasmin Rodarte [UNESP]2018-12-11T17:30:01Z2018-12-11T17:30:01Z2016-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article559-564application/pdfhttp://dx.doi.org/10.1016/j.ajoms.2016.05.015Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, v. 28, n. 6, p. 559-564, 2016.2212-5558http://hdl.handle.net/11449/17838410.1016/j.ajoms.2016.05.0152-s2.0-849926955652-s2.0-84992695565.pdf75953156608584130000-0003-2485-6906Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Oral and Maxillofacial Surgery, Medicine, and Pathology0,153info:eu-repo/semantics/openAccess2023-10-12T06:05:55Zoai:repositorio.unesp.br:11449/178384Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:41:03.081230Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma |
title |
Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma |
spellingShingle |
Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma Bertini, Fernanda [UNESP] CD105 D2-40 Ki-67 Oral cancer Squamous cell cancer |
title_short |
Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma |
title_full |
Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma |
title_fullStr |
Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma |
title_full_unstemmed |
Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma |
title_sort |
Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma |
author |
Bertini, Fernanda [UNESP] |
author_facet |
Bertini, Fernanda [UNESP] do Prado, Renata Falchete [UNESP] de Oliveira, Aline Júnia [UNESP] Tera, Tábata de Melo [UNESP] Rosa, Luiz Eduardo Blumer [UNESP] Seabra, Julia Carvalho Carvalho, Yasmin Rodarte [UNESP] |
author_role |
author |
author2 |
do Prado, Renata Falchete [UNESP] de Oliveira, Aline Júnia [UNESP] Tera, Tábata de Melo [UNESP] Rosa, Luiz Eduardo Blumer [UNESP] Seabra, Julia Carvalho Carvalho, Yasmin Rodarte [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de Santo Amaro – UNISA |
dc.contributor.author.fl_str_mv |
Bertini, Fernanda [UNESP] do Prado, Renata Falchete [UNESP] de Oliveira, Aline Júnia [UNESP] Tera, Tábata de Melo [UNESP] Rosa, Luiz Eduardo Blumer [UNESP] Seabra, Julia Carvalho Carvalho, Yasmin Rodarte [UNESP] |
dc.subject.por.fl_str_mv |
CD105 D2-40 Ki-67 Oral cancer Squamous cell cancer |
topic |
CD105 D2-40 Ki-67 Oral cancer Squamous cell cancer |
description |
Objective Despite the advances in medicine, the oral squamous cell carcinomas still have high incidence and are very important to study topics such as their lymphatic and microvessel density. This research assessed the correlation between histological grading, formation of new lymphatic and blood vessels and cell proliferation in squamous cell carcinomas (SCC). Methods Twenty-nine oral floor SCC and 30 tongue cases were assessed for their clinical characteristics and histological grading of malignancy. Results The presence of VEGF (vascular endothelial growth factor VG1), VEGF-C (vascular endothelial growth factor-C), CD105, to determine blood microvascular (MVD), and D2-40 to determine lymphatic density (LMD) was investigated using immunohistochemistry. Histological grading revealed that 73.3% of tongue and 96.67% of floor cases were classified as highly aggressive. Cell proliferation was greater on the floor; however, no significant difference was observed. Most carcinomas were VEGF negative (tongue 63.3% and floor 70.0%) and VEGF-C positive (tongue 73.3% and floor 79.3%). LMD was considerably greater on the tongue. High MVD values occurred in cases with greater cell proliferation. No relationship was determined between the growth factors VEGF and VEGF-C and MVD and LMD, respectively. Conclusion Floor of mouth SCC cases was morphologically more aggressive than tongue cases; however, in tongue carcinomas a greater quantity of lymphatic vessels could represent potential ways for locoregional cell dissemination of the neoplastic cells, independent of histological grading. Blood vascularization presented correlation with cell proliferation in intraoral squamous cell carcinoma and could be useful in the prognostic assessment of this neoplasm. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01 2018-12-11T17:30:01Z 2018-12-11T17:30:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ajoms.2016.05.015 Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, v. 28, n. 6, p. 559-564, 2016. 2212-5558 http://hdl.handle.net/11449/178384 10.1016/j.ajoms.2016.05.015 2-s2.0-84992695565 2-s2.0-84992695565.pdf 7595315660858413 0000-0003-2485-6906 |
url |
http://dx.doi.org/10.1016/j.ajoms.2016.05.015 http://hdl.handle.net/11449/178384 |
identifier_str_mv |
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, v. 28, n. 6, p. 559-564, 2016. 2212-5558 10.1016/j.ajoms.2016.05.015 2-s2.0-84992695565 2-s2.0-84992695565.pdf 7595315660858413 0000-0003-2485-6906 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 0,153 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
559-564 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128400789864448 |