A atuação da sinvastatina na regeneração periodontal e óssea: revisão de literatura

• Autor(a) principal: Oliveira, Daniele Boina de [UNESP]
• Data de Publicação: 2009
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/156243; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2018-01-15/000894090.pdf
• topic: Sinvastatina; Regeneração óssea; Ligamento periodontal; Simvastatin

Even though periodontal regeneration (formation of new cementum, periodontal ligament and alveolar bone) is a possible goal of many periodontal treatment modalities, their consequences are not always predictable due to the complexity of the events, factors and cells involved in periodontal regeneration (AAP 2005; FOSTER & SOMERMAN, 2005). The appropriate signals, cells, blood supply and scaffold must be present in order to obtain periodontal regeneration (TABA et al., 2005; FOSTER & SOMERMAN, 2005). There is in vivo evidence that a specific type of BMP (rhBMP-2) acts on the proliferation and differentiation of periodontal ligament cells in periodontal fenestration defects in rats, with bone and cementum formation, suggesting that this osteoinductive agent may be used for periodontal regeneration (KING et al., 1992; KING & HUGHES, 2001). Therefore, the search for materials or pharmacological compounds that can up regulate the expression of autogenous growth factors to stimulate tissue regeneration at low cost is desirable (STEIN et al., 2005). Sinvastatin (inhibitors of 3- hydroxyl-3- methyl- glutaryl coenzyme A HMG-CoA reductase, which converts HMG-CoA to mevalonate) is a drug used to decrease cholesterol, inhibiting its biosynthesis. Mundy et al. (1999) have demonstrated that sinvastatin, used in rats, upregulated the expression of RNA-m da BMP-2 in osteoblasts, without the use a bone graft. It is likely that this drug upregulated the expression of BMP-2, leading to the differentiation of osteoblasts. The purpose of this study is to discuss the literature related to the effect of sinvastatin in periodontal regeneration as well as in bone regeneration