Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224001 |
Resumo: | We studied the effect of the α1- and α2-adrenergic receptors of the lateral hypothalamus (LH on the control of water intake induced by injection of carbachol into the medial septal area (MSA) of adult male Holtzman rats (250-300 g) implanted with chronic stainless steel cannulae into the LH and MSA. The volume of injection was always 1 μl and was injected over a period of 30-60 s. For control, 0.15 M NaCl was used. Clonidine (20 nmol) but not phenylephrine (160 nmol) injected into the LH inhibited water intake induced by injection of carbachol (2 nmol) into the MSA, from 5.4 ± l.2 ml/h to 0.3 ± 0.1 and 3.0 ± 0.9 ml/h, respectively (N = 26). When we injected yohimbine (80 nmol) + clonidine (20 nmol) and prazosin (40 nmol) + clonidine (20 nmol) into the LH, water intake induced by injection of carbachol into the MSA was inhibited from 5.4 ± 1.2 ml/h to 0.8 ± 0.5 and 0.3 ± 0.2 ml/h, respectively (N = 19). Water intake induced by carbachol (2 nmol) injected into the MSA was decreased by previous injection of yohimbine (80 nmol) + phenylephrine (160 nmol) and prazosin (40 nmol) + phenylephrine (160 nmol) from 5.4 ± 1.2 ml/h to 1.0 ± 0.7 and 1.8 ± 0.8 ml/h, respectively (N = 16). The cannula reached both the medial septal area in its medial portion and the lateral hypothalamus. It has been suggested that the different pathways for induction of drinking converge on a final common pathway. Thus, adrenergic stimulation of α2-adrenoceptors of LH can influence this final common pathway. |
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Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal areaα1- and α2-adrenoceptorscholinergic receptorslateral hypothalamusseptal areawater intakeWe studied the effect of the α1- and α2-adrenergic receptors of the lateral hypothalamus (LH on the control of water intake induced by injection of carbachol into the medial septal area (MSA) of adult male Holtzman rats (250-300 g) implanted with chronic stainless steel cannulae into the LH and MSA. The volume of injection was always 1 μl and was injected over a period of 30-60 s. For control, 0.15 M NaCl was used. Clonidine (20 nmol) but not phenylephrine (160 nmol) injected into the LH inhibited water intake induced by injection of carbachol (2 nmol) into the MSA, from 5.4 ± l.2 ml/h to 0.3 ± 0.1 and 3.0 ± 0.9 ml/h, respectively (N = 26). When we injected yohimbine (80 nmol) + clonidine (20 nmol) and prazosin (40 nmol) + clonidine (20 nmol) into the LH, water intake induced by injection of carbachol into the MSA was inhibited from 5.4 ± 1.2 ml/h to 0.8 ± 0.5 and 0.3 ± 0.2 ml/h, respectively (N = 19). Water intake induced by carbachol (2 nmol) injected into the MSA was decreased by previous injection of yohimbine (80 nmol) + phenylephrine (160 nmol) and prazosin (40 nmol) + phenylephrine (160 nmol) from 5.4 ± 1.2 ml/h to 1.0 ± 0.7 and 1.8 ± 0.8 ml/h, respectively (N = 16). The cannula reached both the medial septal area in its medial portion and the lateral hypothalamus. It has been suggested that the different pathways for induction of drinking converge on a final common pathway. Thus, adrenergic stimulation of α2-adrenoceptors of LH can influence this final common pathway.Dpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humanita, 1680, 14801-903 Araraquara, SPDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humanita, 1680, 14801-903 Araraquara, SPUniversidade Estadual Paulista (UNESP)Callera, J. C. [UNESP]Saad, W. A. [UNESP]Camargo, L. A.A. [UNESP]Menani, J. V. [UNESP]Renzi, A. [UNESP]Abrao-Saad, W. [UNESP]2022-04-28T19:54:15Z2022-04-28T19:54:15Z1995-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article240-245Brazilian Journal of Medical and Biological Research, v. 28, n. 2, p. 240-245, 1995.0100-879Xhttp://hdl.handle.net/11449/2240012-s2.0-0028951248Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccess2022-04-28T19:54:16Zoai:repositorio.unesp.br:11449/224001Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:54:16Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area |
title |
Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area |
spellingShingle |
Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area Callera, J. C. [UNESP] α1- and α2-adrenoceptors cholinergic receptors lateral hypothalamus septal area water intake |
title_short |
Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area |
title_full |
Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area |
title_fullStr |
Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area |
title_full_unstemmed |
Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area |
title_sort |
Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area |
author |
Callera, J. C. [UNESP] |
author_facet |
Callera, J. C. [UNESP] Saad, W. A. [UNESP] Camargo, L. A.A. [UNESP] Menani, J. V. [UNESP] Renzi, A. [UNESP] Abrao-Saad, W. [UNESP] |
author_role |
author |
author2 |
Saad, W. A. [UNESP] Camargo, L. A.A. [UNESP] Menani, J. V. [UNESP] Renzi, A. [UNESP] Abrao-Saad, W. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Callera, J. C. [UNESP] Saad, W. A. [UNESP] Camargo, L. A.A. [UNESP] Menani, J. V. [UNESP] Renzi, A. [UNESP] Abrao-Saad, W. [UNESP] |
dc.subject.por.fl_str_mv |
α1- and α2-adrenoceptors cholinergic receptors lateral hypothalamus septal area water intake |
topic |
α1- and α2-adrenoceptors cholinergic receptors lateral hypothalamus septal area water intake |
description |
We studied the effect of the α1- and α2-adrenergic receptors of the lateral hypothalamus (LH on the control of water intake induced by injection of carbachol into the medial septal area (MSA) of adult male Holtzman rats (250-300 g) implanted with chronic stainless steel cannulae into the LH and MSA. The volume of injection was always 1 μl and was injected over a period of 30-60 s. For control, 0.15 M NaCl was used. Clonidine (20 nmol) but not phenylephrine (160 nmol) injected into the LH inhibited water intake induced by injection of carbachol (2 nmol) into the MSA, from 5.4 ± l.2 ml/h to 0.3 ± 0.1 and 3.0 ± 0.9 ml/h, respectively (N = 26). When we injected yohimbine (80 nmol) + clonidine (20 nmol) and prazosin (40 nmol) + clonidine (20 nmol) into the LH, water intake induced by injection of carbachol into the MSA was inhibited from 5.4 ± 1.2 ml/h to 0.8 ± 0.5 and 0.3 ± 0.2 ml/h, respectively (N = 19). Water intake induced by carbachol (2 nmol) injected into the MSA was decreased by previous injection of yohimbine (80 nmol) + phenylephrine (160 nmol) and prazosin (40 nmol) + phenylephrine (160 nmol) from 5.4 ± 1.2 ml/h to 1.0 ± 0.7 and 1.8 ± 0.8 ml/h, respectively (N = 16). The cannula reached both the medial septal area in its medial portion and the lateral hypothalamus. It has been suggested that the different pathways for induction of drinking converge on a final common pathway. Thus, adrenergic stimulation of α2-adrenoceptors of LH can influence this final common pathway. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-01-01 2022-04-28T19:54:15Z 2022-04-28T19:54:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Brazilian Journal of Medical and Biological Research, v. 28, n. 2, p. 240-245, 1995. 0100-879X http://hdl.handle.net/11449/224001 2-s2.0-0028951248 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research, v. 28, n. 2, p. 240-245, 1995. 0100-879X 2-s2.0-0028951248 |
url |
http://hdl.handle.net/11449/224001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
240-245 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803047026997329920 |