Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Vernal, Sebastian
Data de Publicação: 2017
Outros Autores: Pepinelli, Mateus, Casanova, Claudio, Goulart, Thais M., Kim, Olivia, De Paula, Natalia A., Pinto, Mara C. [UNESP], Sa-Nunes, Anderson, Roselino, Ana Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.actatropica.2017.09.015
http://hdl.handle.net/11449/164779
Resumo: Background: Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil. Purpose: To georeference the distribution of Simuliidae (Diptera: Simuliidae) and Phlebotominae (Diptera: Psychodidae) and of PF cases in the northeastern region of Sao Paulo State, and to assess the humoral immune response against salivary gland extracts (SGEs) from biting flies in PF patients, relatives, and neighbours. Methods: PF patients' medical information recorded between 1965 and 2014 were obtained from the database of the University Hospital. Data on the distribution of fly species were collected from scientific reports and epidemiological databases. Spatial maps relating the distribution of biting flies with PF cases ware plotted. Serum IgG antibodies against the SGEs from Simulium nigrimanum, Nyssomyia neivai, and Aedes aegypti (as control) were determined by ELISA. Results: Two hundred and eighty-five PF cases were distributed in 60 municipalities with a prevalence of 57.5 per million inhabitants, revealing well-defined geographical clusters. S. nigrimanum and N. neivai specimens were registered in eight (13.3%) and 26 (43.3%) of these municipalities, respectively. PF patients, and their relatives presented higher levels of IgG against the SGEs of S. nigrimanum and N. neivai (P < 0.001 for both), but not against the SGE from A. aegypti (P = 0.115 and P = 0.552, respectively), as compared to controls. IgG against the SGEs from S. nigrimanum and N. neivai but not against the SGE from A. aegypti correlated with levels of anti-Desmoglein 1 in PF patients (r = 0.3848, P = 0.039; and r = 0.416, P = 0.022, respectively). Conclusion: An epidemiological link between biting flies and PF in southeastern Brazil is proposed, implying a possible role of the salivary proteins from these flies in PF etiopathogenesis.
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spelling Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern BrazilPemphigus foliaceusBlack fliesSandfliesSimuliidaePhlebotomineBackground: Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil. Purpose: To georeference the distribution of Simuliidae (Diptera: Simuliidae) and Phlebotominae (Diptera: Psychodidae) and of PF cases in the northeastern region of Sao Paulo State, and to assess the humoral immune response against salivary gland extracts (SGEs) from biting flies in PF patients, relatives, and neighbours. Methods: PF patients' medical information recorded between 1965 and 2014 were obtained from the database of the University Hospital. Data on the distribution of fly species were collected from scientific reports and epidemiological databases. Spatial maps relating the distribution of biting flies with PF cases ware plotted. Serum IgG antibodies against the SGEs from Simulium nigrimanum, Nyssomyia neivai, and Aedes aegypti (as control) were determined by ELISA. Results: Two hundred and eighty-five PF cases were distributed in 60 municipalities with a prevalence of 57.5 per million inhabitants, revealing well-defined geographical clusters. S. nigrimanum and N. neivai specimens were registered in eight (13.3%) and 26 (43.3%) of these municipalities, respectively. PF patients, and their relatives presented higher levels of IgG against the SGEs of S. nigrimanum and N. neivai (P < 0.001 for both), but not against the SGE from A. aegypti (P = 0.115 and P = 0.552, respectively), as compared to controls. IgG against the SGEs from S. nigrimanum and N. neivai but not against the SGE from A. aegypti correlated with levels of anti-Desmoglein 1 in PF patients (r = 0.3848, P = 0.039; and r = 0.416, P = 0.022, respectively). Conclusion: An epidemiological link between biting flies and PF in southeastern Brazil is proposed, implying a possible role of the salivary proteins from these flies in PF etiopathogenesis.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)NAP-MOBIARVE (Nucleo de Pesquisa em Moleculas Bioativas de Artropodes Vetores)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Sao Paulo, Ribeirao Preto Med Sch, Div Dermatol, Dept Clin Med, Ribeirao Preto, SP, BrazilRoyal Ontario Museum, Dept Nat Hist, Toronto, ON, CanadaUniv Toronto, Dept Ecol & Evolutionary Biol, Toronto, ON, CanadaHlth Secretariat Sao Paulo State, Superintendence Endem Dis Control, Mogi Guacu, SP, BrazilUniv Estadual Campinas, Inst Biol, Dept Anim Biol, Campinas, SP, BrazilSao Paulo State Univ Julio Mesquita Filho, Dept Parasitol, Araraquara, SP, BrazilUniv Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, BrazilSao Paulo State Univ Julio Mesquita Filho, Dept Parasitol, Araraquara, SP, BrazilFAPESP: 2010/51729-2NAP-MOBIARVE (Nucleo de Pesquisa em Moleculas Bioativas de Artropodes Vetores): 12.1.17661.1.7Elsevier B.V.Universidade de São Paulo (USP)Royal Ontario MuseumUniv TorontoHlth Secretariat Sao Paulo StateUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Vernal, SebastianPepinelli, MateusCasanova, ClaudioGoulart, Thais M.Kim, OliviaDe Paula, Natalia A.Pinto, Mara C. [UNESP]Sa-Nunes, AndersonRoselino, Ana Maria2018-11-26T17:56:04Z2018-11-26T17:56:04Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article455-462application/pdfhttp://dx.doi.org/10.1016/j.actatropica.2017.09.015Acta Tropica. Amsterdam: Elsevier Science Bv, v. 176, p. 455-462, 2017.0001-706Xhttp://hdl.handle.net/11449/16477910.1016/j.actatropica.2017.09.015WOS:000413606800065WOS000413606800065.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Tropicainfo:eu-repo/semantics/openAccess2023-10-21T06:07:12Zoai:repositorio.unesp.br:11449/164779Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-21T06:07:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
title Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
spellingShingle Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
Vernal, Sebastian
Pemphigus foliaceus
Black flies
Sandflies
Simuliidae
Phlebotomine
title_short Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
title_full Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
title_fullStr Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
title_full_unstemmed Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
title_sort Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
author Vernal, Sebastian
author_facet Vernal, Sebastian
Pepinelli, Mateus
Casanova, Claudio
Goulart, Thais M.
Kim, Olivia
De Paula, Natalia A.
Pinto, Mara C. [UNESP]
Sa-Nunes, Anderson
Roselino, Ana Maria
author_role author
author2 Pepinelli, Mateus
Casanova, Claudio
Goulart, Thais M.
Kim, Olivia
De Paula, Natalia A.
Pinto, Mara C. [UNESP]
Sa-Nunes, Anderson
Roselino, Ana Maria
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Royal Ontario Museum
Univ Toronto
Hlth Secretariat Sao Paulo State
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Vernal, Sebastian
Pepinelli, Mateus
Casanova, Claudio
Goulart, Thais M.
Kim, Olivia
De Paula, Natalia A.
Pinto, Mara C. [UNESP]
Sa-Nunes, Anderson
Roselino, Ana Maria
dc.subject.por.fl_str_mv Pemphigus foliaceus
Black flies
Sandflies
Simuliidae
Phlebotomine
topic Pemphigus foliaceus
Black flies
Sandflies
Simuliidae
Phlebotomine
description Background: Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil. Purpose: To georeference the distribution of Simuliidae (Diptera: Simuliidae) and Phlebotominae (Diptera: Psychodidae) and of PF cases in the northeastern region of Sao Paulo State, and to assess the humoral immune response against salivary gland extracts (SGEs) from biting flies in PF patients, relatives, and neighbours. Methods: PF patients' medical information recorded between 1965 and 2014 were obtained from the database of the University Hospital. Data on the distribution of fly species were collected from scientific reports and epidemiological databases. Spatial maps relating the distribution of biting flies with PF cases ware plotted. Serum IgG antibodies against the SGEs from Simulium nigrimanum, Nyssomyia neivai, and Aedes aegypti (as control) were determined by ELISA. Results: Two hundred and eighty-five PF cases were distributed in 60 municipalities with a prevalence of 57.5 per million inhabitants, revealing well-defined geographical clusters. S. nigrimanum and N. neivai specimens were registered in eight (13.3%) and 26 (43.3%) of these municipalities, respectively. PF patients, and their relatives presented higher levels of IgG against the SGEs of S. nigrimanum and N. neivai (P < 0.001 for both), but not against the SGE from A. aegypti (P = 0.115 and P = 0.552, respectively), as compared to controls. IgG against the SGEs from S. nigrimanum and N. neivai but not against the SGE from A. aegypti correlated with levels of anti-Desmoglein 1 in PF patients (r = 0.3848, P = 0.039; and r = 0.416, P = 0.022, respectively). Conclusion: An epidemiological link between biting flies and PF in southeastern Brazil is proposed, implying a possible role of the salivary proteins from these flies in PF etiopathogenesis.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
2018-11-26T17:56:04Z
2018-11-26T17:56:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.actatropica.2017.09.015
Acta Tropica. Amsterdam: Elsevier Science Bv, v. 176, p. 455-462, 2017.
0001-706X
http://hdl.handle.net/11449/164779
10.1016/j.actatropica.2017.09.015
WOS:000413606800065
WOS000413606800065.pdf
url http://dx.doi.org/10.1016/j.actatropica.2017.09.015
http://hdl.handle.net/11449/164779
identifier_str_mv Acta Tropica. Amsterdam: Elsevier Science Bv, v. 176, p. 455-462, 2017.
0001-706X
10.1016/j.actatropica.2017.09.015
WOS:000413606800065
WOS000413606800065.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Tropica
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 455-462
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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