Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.actatropica.2017.09.015 http://hdl.handle.net/11449/164779 |
Resumo: | Background: Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil. Purpose: To georeference the distribution of Simuliidae (Diptera: Simuliidae) and Phlebotominae (Diptera: Psychodidae) and of PF cases in the northeastern region of Sao Paulo State, and to assess the humoral immune response against salivary gland extracts (SGEs) from biting flies in PF patients, relatives, and neighbours. Methods: PF patients' medical information recorded between 1965 and 2014 were obtained from the database of the University Hospital. Data on the distribution of fly species were collected from scientific reports and epidemiological databases. Spatial maps relating the distribution of biting flies with PF cases ware plotted. Serum IgG antibodies against the SGEs from Simulium nigrimanum, Nyssomyia neivai, and Aedes aegypti (as control) were determined by ELISA. Results: Two hundred and eighty-five PF cases were distributed in 60 municipalities with a prevalence of 57.5 per million inhabitants, revealing well-defined geographical clusters. S. nigrimanum and N. neivai specimens were registered in eight (13.3%) and 26 (43.3%) of these municipalities, respectively. PF patients, and their relatives presented higher levels of IgG against the SGEs of S. nigrimanum and N. neivai (P < 0.001 for both), but not against the SGE from A. aegypti (P = 0.115 and P = 0.552, respectively), as compared to controls. IgG against the SGEs from S. nigrimanum and N. neivai but not against the SGE from A. aegypti correlated with levels of anti-Desmoglein 1 in PF patients (r = 0.3848, P = 0.039; and r = 0.416, P = 0.022, respectively). Conclusion: An epidemiological link between biting flies and PF in southeastern Brazil is proposed, implying a possible role of the salivary proteins from these flies in PF etiopathogenesis. |
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Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern BrazilPemphigus foliaceusBlack fliesSandfliesSimuliidaePhlebotomineBackground: Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil. Purpose: To georeference the distribution of Simuliidae (Diptera: Simuliidae) and Phlebotominae (Diptera: Psychodidae) and of PF cases in the northeastern region of Sao Paulo State, and to assess the humoral immune response against salivary gland extracts (SGEs) from biting flies in PF patients, relatives, and neighbours. Methods: PF patients' medical information recorded between 1965 and 2014 were obtained from the database of the University Hospital. Data on the distribution of fly species were collected from scientific reports and epidemiological databases. Spatial maps relating the distribution of biting flies with PF cases ware plotted. Serum IgG antibodies against the SGEs from Simulium nigrimanum, Nyssomyia neivai, and Aedes aegypti (as control) were determined by ELISA. Results: Two hundred and eighty-five PF cases were distributed in 60 municipalities with a prevalence of 57.5 per million inhabitants, revealing well-defined geographical clusters. S. nigrimanum and N. neivai specimens were registered in eight (13.3%) and 26 (43.3%) of these municipalities, respectively. PF patients, and their relatives presented higher levels of IgG against the SGEs of S. nigrimanum and N. neivai (P < 0.001 for both), but not against the SGE from A. aegypti (P = 0.115 and P = 0.552, respectively), as compared to controls. IgG against the SGEs from S. nigrimanum and N. neivai but not against the SGE from A. aegypti correlated with levels of anti-Desmoglein 1 in PF patients (r = 0.3848, P = 0.039; and r = 0.416, P = 0.022, respectively). Conclusion: An epidemiological link between biting flies and PF in southeastern Brazil is proposed, implying a possible role of the salivary proteins from these flies in PF etiopathogenesis.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)NAP-MOBIARVE (Nucleo de Pesquisa em Moleculas Bioativas de Artropodes Vetores)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Sao Paulo, Ribeirao Preto Med Sch, Div Dermatol, Dept Clin Med, Ribeirao Preto, SP, BrazilRoyal Ontario Museum, Dept Nat Hist, Toronto, ON, CanadaUniv Toronto, Dept Ecol & Evolutionary Biol, Toronto, ON, CanadaHlth Secretariat Sao Paulo State, Superintendence Endem Dis Control, Mogi Guacu, SP, BrazilUniv Estadual Campinas, Inst Biol, Dept Anim Biol, Campinas, SP, BrazilSao Paulo State Univ Julio Mesquita Filho, Dept Parasitol, Araraquara, SP, BrazilUniv Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, BrazilSao Paulo State Univ Julio Mesquita Filho, Dept Parasitol, Araraquara, SP, BrazilFAPESP: 2010/51729-2NAP-MOBIARVE (Nucleo de Pesquisa em Moleculas Bioativas de Artropodes Vetores): 12.1.17661.1.7Elsevier B.V.Universidade de São Paulo (USP)Royal Ontario MuseumUniv TorontoHlth Secretariat Sao Paulo StateUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Vernal, SebastianPepinelli, MateusCasanova, ClaudioGoulart, Thais M.Kim, OliviaDe Paula, Natalia A.Pinto, Mara C. [UNESP]Sa-Nunes, AndersonRoselino, Ana Maria2018-11-26T17:56:04Z2018-11-26T17:56:04Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article455-462application/pdfhttp://dx.doi.org/10.1016/j.actatropica.2017.09.015Acta Tropica. Amsterdam: Elsevier Science Bv, v. 176, p. 455-462, 2017.0001-706Xhttp://hdl.handle.net/11449/16477910.1016/j.actatropica.2017.09.015WOS:000413606800065WOS000413606800065.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Tropicainfo:eu-repo/semantics/openAccess2024-08-14T17:22:26Zoai:repositorio.unesp.br:11449/164779Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil |
title |
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil |
spellingShingle |
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil Vernal, Sebastian Pemphigus foliaceus Black flies Sandflies Simuliidae Phlebotomine |
title_short |
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil |
title_full |
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil |
title_fullStr |
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil |
title_full_unstemmed |
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil |
title_sort |
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil |
author |
Vernal, Sebastian |
author_facet |
Vernal, Sebastian Pepinelli, Mateus Casanova, Claudio Goulart, Thais M. Kim, Olivia De Paula, Natalia A. Pinto, Mara C. [UNESP] Sa-Nunes, Anderson Roselino, Ana Maria |
author_role |
author |
author2 |
Pepinelli, Mateus Casanova, Claudio Goulart, Thais M. Kim, Olivia De Paula, Natalia A. Pinto, Mara C. [UNESP] Sa-Nunes, Anderson Roselino, Ana Maria |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Royal Ontario Museum Univ Toronto Hlth Secretariat Sao Paulo State Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Vernal, Sebastian Pepinelli, Mateus Casanova, Claudio Goulart, Thais M. Kim, Olivia De Paula, Natalia A. Pinto, Mara C. [UNESP] Sa-Nunes, Anderson Roselino, Ana Maria |
dc.subject.por.fl_str_mv |
Pemphigus foliaceus Black flies Sandflies Simuliidae Phlebotomine |
topic |
Pemphigus foliaceus Black flies Sandflies Simuliidae Phlebotomine |
description |
Background: Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil. Purpose: To georeference the distribution of Simuliidae (Diptera: Simuliidae) and Phlebotominae (Diptera: Psychodidae) and of PF cases in the northeastern region of Sao Paulo State, and to assess the humoral immune response against salivary gland extracts (SGEs) from biting flies in PF patients, relatives, and neighbours. Methods: PF patients' medical information recorded between 1965 and 2014 were obtained from the database of the University Hospital. Data on the distribution of fly species were collected from scientific reports and epidemiological databases. Spatial maps relating the distribution of biting flies with PF cases ware plotted. Serum IgG antibodies against the SGEs from Simulium nigrimanum, Nyssomyia neivai, and Aedes aegypti (as control) were determined by ELISA. Results: Two hundred and eighty-five PF cases were distributed in 60 municipalities with a prevalence of 57.5 per million inhabitants, revealing well-defined geographical clusters. S. nigrimanum and N. neivai specimens were registered in eight (13.3%) and 26 (43.3%) of these municipalities, respectively. PF patients, and their relatives presented higher levels of IgG against the SGEs of S. nigrimanum and N. neivai (P < 0.001 for both), but not against the SGE from A. aegypti (P = 0.115 and P = 0.552, respectively), as compared to controls. IgG against the SGEs from S. nigrimanum and N. neivai but not against the SGE from A. aegypti correlated with levels of anti-Desmoglein 1 in PF patients (r = 0.3848, P = 0.039; and r = 0.416, P = 0.022, respectively). Conclusion: An epidemiological link between biting flies and PF in southeastern Brazil is proposed, implying a possible role of the salivary proteins from these flies in PF etiopathogenesis. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 2018-11-26T17:56:04Z 2018-11-26T17:56:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.actatropica.2017.09.015 Acta Tropica. Amsterdam: Elsevier Science Bv, v. 176, p. 455-462, 2017. 0001-706X http://hdl.handle.net/11449/164779 10.1016/j.actatropica.2017.09.015 WOS:000413606800065 WOS000413606800065.pdf |
url |
http://dx.doi.org/10.1016/j.actatropica.2017.09.015 http://hdl.handle.net/11449/164779 |
identifier_str_mv |
Acta Tropica. Amsterdam: Elsevier Science Bv, v. 176, p. 455-462, 2017. 0001-706X 10.1016/j.actatropica.2017.09.015 WOS:000413606800065 WOS000413606800065.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Tropica |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
455-462 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128122323730432 |