Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.marpolbul.2019.02.065 http://hdl.handle.net/11449/185636 |
Resumo: | Concerns are growing about the presence of fluoxetine (FLX) in environmental matrices, as well as its harmful effects on non-target organisms. FLX in aquatic ecosystems has been detected in a range varying from pg/L to ng/L, while adverse effects have been reported in several organisms inhabiting freshwater and marine environments. The present study quantifies FLX concentrations in seawater samples from Santos Bay, Brazil and assesses metabolic responses and sublethal effects on the tropical brown mussel Perna pema. Levels of ethoxyresorufin-O-deethylase, dibenzylfluorescein dealkylase, glutathione S-transferase, glutathione peroxidase, cholinesterase, lipoperoxidation, and DNA damage were assessed in the gills and digestive gland of these animals, and lysosomal membrane stability was also assessed in hemocytes. FLX altered phase I and II enzyme activities, caused cytogenotoxic effects, and negatively impacted the overall health of mussels exposed to environmentally relevant concentrations. These findings contribute to characterize the risks of introducing this drug into the marine environment. |
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Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna pernaAntidepressantsContaminants of emerging concernTropical ecotoxicologyBivalvesBrazilConcerns are growing about the presence of fluoxetine (FLX) in environmental matrices, as well as its harmful effects on non-target organisms. FLX in aquatic ecosystems has been detected in a range varying from pg/L to ng/L, while adverse effects have been reported in several organisms inhabiting freshwater and marine environments. The present study quantifies FLX concentrations in seawater samples from Santos Bay, Brazil and assesses metabolic responses and sublethal effects on the tropical brown mussel Perna pema. Levels of ethoxyresorufin-O-deethylase, dibenzylfluorescein dealkylase, glutathione S-transferase, glutathione peroxidase, cholinesterase, lipoperoxidation, and DNA damage were assessed in the gills and digestive gland of these animals, and lysosomal membrane stability was also assessed in hemocytes. FLX altered phase I and II enzyme activities, caused cytogenotoxic effects, and negatively impacted the overall health of mussels exposed to environmentally relevant concentrations. These findings contribute to characterize the risks of introducing this drug into the marine environment.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Santa Cecilia, Rua Oswaldo Cruz 266, BR-11045907 Santos, SP, BrazilUniv Estadual Paulista Julio de Mesquita, Pr Infante Dom Henrique S-N, BR-11330900 Sao Vicente, BrazilUniv Cadiz, Poligono Rio San Pedro S-N, Puerto Real 11510, SpainUniv Fed Sao Paulo, Rua Maria Maximo 168, BR-11030100 Santos, SP, BrazilUniv Estadual Paulista Julio de Mesquita, Pr Infante Dom Henrique S-N, BR-11330900 Sao Vicente, BrazilCNPq: 481358/2012-9CNPq: 481553/2012-6CNPq: 166122/2015-7Elsevier B.V.Univ Santa CeciliaUniversidade Estadual Paulista (Unesp)Univ CadizUniversidade Federal de São Paulo (UNIFESP)Cortez, Fernando Sanzi [UNESP]Silva Souza, Lorena daGuimaraes, Luciana LopesPusceddu, Fabio HermesMaranho, Luciane AlvesFontes, Mayana Karoline [UNESP]Moreno, Beatriz BarbosaNobre, Caio Rodrigues [UNESP]Souza Abessa, Denis Moledo de [UNESP]Cesar, AugustoSeabra Pereira, Camilo Dias2019-10-04T12:37:12Z2019-10-04T12:37:12Z2019-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article366-372http://dx.doi.org/10.1016/j.marpolbul.2019.02.065Marine Pollution Bulletin. Oxford: Pergamon-elsevier Science Ltd, v. 141, p. 366-372, 2019.0025-326Xhttp://hdl.handle.net/11449/18563610.1016/j.marpolbul.2019.02.065WOS:000465509700042Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMarine Pollution Bulletininfo:eu-repo/semantics/openAccess2021-10-22T21:15:46Zoai:repositorio.unesp.br:11449/185636Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:08:13.518179Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna |
title |
Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna |
spellingShingle |
Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna Cortez, Fernando Sanzi [UNESP] Antidepressants Contaminants of emerging concern Tropical ecotoxicology Bivalves Brazil |
title_short |
Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna |
title_full |
Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna |
title_fullStr |
Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna |
title_full_unstemmed |
Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna |
title_sort |
Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna |
author |
Cortez, Fernando Sanzi [UNESP] |
author_facet |
Cortez, Fernando Sanzi [UNESP] Silva Souza, Lorena da Guimaraes, Luciana Lopes Pusceddu, Fabio Hermes Maranho, Luciane Alves Fontes, Mayana Karoline [UNESP] Moreno, Beatriz Barbosa Nobre, Caio Rodrigues [UNESP] Souza Abessa, Denis Moledo de [UNESP] Cesar, Augusto Seabra Pereira, Camilo Dias |
author_role |
author |
author2 |
Silva Souza, Lorena da Guimaraes, Luciana Lopes Pusceddu, Fabio Hermes Maranho, Luciane Alves Fontes, Mayana Karoline [UNESP] Moreno, Beatriz Barbosa Nobre, Caio Rodrigues [UNESP] Souza Abessa, Denis Moledo de [UNESP] Cesar, Augusto Seabra Pereira, Camilo Dias |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Santa Cecilia Universidade Estadual Paulista (Unesp) Univ Cadiz Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Cortez, Fernando Sanzi [UNESP] Silva Souza, Lorena da Guimaraes, Luciana Lopes Pusceddu, Fabio Hermes Maranho, Luciane Alves Fontes, Mayana Karoline [UNESP] Moreno, Beatriz Barbosa Nobre, Caio Rodrigues [UNESP] Souza Abessa, Denis Moledo de [UNESP] Cesar, Augusto Seabra Pereira, Camilo Dias |
dc.subject.por.fl_str_mv |
Antidepressants Contaminants of emerging concern Tropical ecotoxicology Bivalves Brazil |
topic |
Antidepressants Contaminants of emerging concern Tropical ecotoxicology Bivalves Brazil |
description |
Concerns are growing about the presence of fluoxetine (FLX) in environmental matrices, as well as its harmful effects on non-target organisms. FLX in aquatic ecosystems has been detected in a range varying from pg/L to ng/L, while adverse effects have been reported in several organisms inhabiting freshwater and marine environments. The present study quantifies FLX concentrations in seawater samples from Santos Bay, Brazil and assesses metabolic responses and sublethal effects on the tropical brown mussel Perna pema. Levels of ethoxyresorufin-O-deethylase, dibenzylfluorescein dealkylase, glutathione S-transferase, glutathione peroxidase, cholinesterase, lipoperoxidation, and DNA damage were assessed in the gills and digestive gland of these animals, and lysosomal membrane stability was also assessed in hemocytes. FLX altered phase I and II enzyme activities, caused cytogenotoxic effects, and negatively impacted the overall health of mussels exposed to environmentally relevant concentrations. These findings contribute to characterize the risks of introducing this drug into the marine environment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:37:12Z 2019-10-04T12:37:12Z 2019-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.marpolbul.2019.02.065 Marine Pollution Bulletin. Oxford: Pergamon-elsevier Science Ltd, v. 141, p. 366-372, 2019. 0025-326X http://hdl.handle.net/11449/185636 10.1016/j.marpolbul.2019.02.065 WOS:000465509700042 |
url |
http://dx.doi.org/10.1016/j.marpolbul.2019.02.065 http://hdl.handle.net/11449/185636 |
identifier_str_mv |
Marine Pollution Bulletin. Oxford: Pergamon-elsevier Science Ltd, v. 141, p. 366-372, 2019. 0025-326X 10.1016/j.marpolbul.2019.02.065 WOS:000465509700042 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marine Pollution Bulletin |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
366-372 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128466158092288 |