Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna

Detalhes bibliográficos
Autor(a) principal: Cortez, Fernando Sanzi [UNESP]
Data de Publicação: 2019
Outros Autores: Silva Souza, Lorena da, Guimaraes, Luciana Lopes, Pusceddu, Fabio Hermes, Maranho, Luciane Alves, Fontes, Mayana Karoline [UNESP], Moreno, Beatriz Barbosa, Nobre, Caio Rodrigues [UNESP], Souza Abessa, Denis Moledo de [UNESP], Cesar, Augusto, Seabra Pereira, Camilo Dias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.marpolbul.2019.02.065
http://hdl.handle.net/11449/185636
Resumo: Concerns are growing about the presence of fluoxetine (FLX) in environmental matrices, as well as its harmful effects on non-target organisms. FLX in aquatic ecosystems has been detected in a range varying from pg/L to ng/L, while adverse effects have been reported in several organisms inhabiting freshwater and marine environments. The present study quantifies FLX concentrations in seawater samples from Santos Bay, Brazil and assesses metabolic responses and sublethal effects on the tropical brown mussel Perna pema. Levels of ethoxyresorufin-O-deethylase, dibenzylfluorescein dealkylase, glutathione S-transferase, glutathione peroxidase, cholinesterase, lipoperoxidation, and DNA damage were assessed in the gills and digestive gland of these animals, and lysosomal membrane stability was also assessed in hemocytes. FLX altered phase I and II enzyme activities, caused cytogenotoxic effects, and negatively impacted the overall health of mussels exposed to environmentally relevant concentrations. These findings contribute to characterize the risks of introducing this drug into the marine environment.
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spelling Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna pernaAntidepressantsContaminants of emerging concernTropical ecotoxicologyBivalvesBrazilConcerns are growing about the presence of fluoxetine (FLX) in environmental matrices, as well as its harmful effects on non-target organisms. FLX in aquatic ecosystems has been detected in a range varying from pg/L to ng/L, while adverse effects have been reported in several organisms inhabiting freshwater and marine environments. The present study quantifies FLX concentrations in seawater samples from Santos Bay, Brazil and assesses metabolic responses and sublethal effects on the tropical brown mussel Perna pema. Levels of ethoxyresorufin-O-deethylase, dibenzylfluorescein dealkylase, glutathione S-transferase, glutathione peroxidase, cholinesterase, lipoperoxidation, and DNA damage were assessed in the gills and digestive gland of these animals, and lysosomal membrane stability was also assessed in hemocytes. FLX altered phase I and II enzyme activities, caused cytogenotoxic effects, and negatively impacted the overall health of mussels exposed to environmentally relevant concentrations. These findings contribute to characterize the risks of introducing this drug into the marine environment.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Santa Cecilia, Rua Oswaldo Cruz 266, BR-11045907 Santos, SP, BrazilUniv Estadual Paulista Julio de Mesquita, Pr Infante Dom Henrique S-N, BR-11330900 Sao Vicente, BrazilUniv Cadiz, Poligono Rio San Pedro S-N, Puerto Real 11510, SpainUniv Fed Sao Paulo, Rua Maria Maximo 168, BR-11030100 Santos, SP, BrazilUniv Estadual Paulista Julio de Mesquita, Pr Infante Dom Henrique S-N, BR-11330900 Sao Vicente, BrazilCNPq: 481358/2012-9CNPq: 481553/2012-6CNPq: 166122/2015-7Elsevier B.V.Univ Santa CeciliaUniversidade Estadual Paulista (Unesp)Univ CadizUniversidade Federal de São Paulo (UNIFESP)Cortez, Fernando Sanzi [UNESP]Silva Souza, Lorena daGuimaraes, Luciana LopesPusceddu, Fabio HermesMaranho, Luciane AlvesFontes, Mayana Karoline [UNESP]Moreno, Beatriz BarbosaNobre, Caio Rodrigues [UNESP]Souza Abessa, Denis Moledo de [UNESP]Cesar, AugustoSeabra Pereira, Camilo Dias2019-10-04T12:37:12Z2019-10-04T12:37:12Z2019-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article366-372http://dx.doi.org/10.1016/j.marpolbul.2019.02.065Marine Pollution Bulletin. Oxford: Pergamon-elsevier Science Ltd, v. 141, p. 366-372, 2019.0025-326Xhttp://hdl.handle.net/11449/18563610.1016/j.marpolbul.2019.02.065WOS:000465509700042Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMarine Pollution Bulletininfo:eu-repo/semantics/openAccess2021-10-22T21:15:46Zoai:repositorio.unesp.br:11449/185636Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:08:13.518179Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
title Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
spellingShingle Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
Cortez, Fernando Sanzi [UNESP]
Antidepressants
Contaminants of emerging concern
Tropical ecotoxicology
Bivalves
Brazil
title_short Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
title_full Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
title_fullStr Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
title_full_unstemmed Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
title_sort Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
author Cortez, Fernando Sanzi [UNESP]
author_facet Cortez, Fernando Sanzi [UNESP]
Silva Souza, Lorena da
Guimaraes, Luciana Lopes
Pusceddu, Fabio Hermes
Maranho, Luciane Alves
Fontes, Mayana Karoline [UNESP]
Moreno, Beatriz Barbosa
Nobre, Caio Rodrigues [UNESP]
Souza Abessa, Denis Moledo de [UNESP]
Cesar, Augusto
Seabra Pereira, Camilo Dias
author_role author
author2 Silva Souza, Lorena da
Guimaraes, Luciana Lopes
Pusceddu, Fabio Hermes
Maranho, Luciane Alves
Fontes, Mayana Karoline [UNESP]
Moreno, Beatriz Barbosa
Nobre, Caio Rodrigues [UNESP]
Souza Abessa, Denis Moledo de [UNESP]
Cesar, Augusto
Seabra Pereira, Camilo Dias
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Santa Cecilia
Universidade Estadual Paulista (Unesp)
Univ Cadiz
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Cortez, Fernando Sanzi [UNESP]
Silva Souza, Lorena da
Guimaraes, Luciana Lopes
Pusceddu, Fabio Hermes
Maranho, Luciane Alves
Fontes, Mayana Karoline [UNESP]
Moreno, Beatriz Barbosa
Nobre, Caio Rodrigues [UNESP]
Souza Abessa, Denis Moledo de [UNESP]
Cesar, Augusto
Seabra Pereira, Camilo Dias
dc.subject.por.fl_str_mv Antidepressants
Contaminants of emerging concern
Tropical ecotoxicology
Bivalves
Brazil
topic Antidepressants
Contaminants of emerging concern
Tropical ecotoxicology
Bivalves
Brazil
description Concerns are growing about the presence of fluoxetine (FLX) in environmental matrices, as well as its harmful effects on non-target organisms. FLX in aquatic ecosystems has been detected in a range varying from pg/L to ng/L, while adverse effects have been reported in several organisms inhabiting freshwater and marine environments. The present study quantifies FLX concentrations in seawater samples from Santos Bay, Brazil and assesses metabolic responses and sublethal effects on the tropical brown mussel Perna pema. Levels of ethoxyresorufin-O-deethylase, dibenzylfluorescein dealkylase, glutathione S-transferase, glutathione peroxidase, cholinesterase, lipoperoxidation, and DNA damage were assessed in the gills and digestive gland of these animals, and lysosomal membrane stability was also assessed in hemocytes. FLX altered phase I and II enzyme activities, caused cytogenotoxic effects, and negatively impacted the overall health of mussels exposed to environmentally relevant concentrations. These findings contribute to characterize the risks of introducing this drug into the marine environment.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T12:37:12Z
2019-10-04T12:37:12Z
2019-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.marpolbul.2019.02.065
Marine Pollution Bulletin. Oxford: Pergamon-elsevier Science Ltd, v. 141, p. 366-372, 2019.
0025-326X
http://hdl.handle.net/11449/185636
10.1016/j.marpolbul.2019.02.065
WOS:000465509700042
url http://dx.doi.org/10.1016/j.marpolbul.2019.02.065
http://hdl.handle.net/11449/185636
identifier_str_mv Marine Pollution Bulletin. Oxford: Pergamon-elsevier Science Ltd, v. 141, p. 366-372, 2019.
0025-326X
10.1016/j.marpolbul.2019.02.065
WOS:000465509700042
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marine Pollution Bulletin
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 366-372
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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