Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.tvjl.2019.05.002 http://hdl.handle.net/11449/189082 |
Resumo: | Warmblood Fragile Foal Syndrome (WFFS)is an autosomal recessive genetic disorder caused by a mutation in the procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1)gene, associated with collagen biosynthesis. WFFS causes lesions and malformations of the skin in neonatal foals, and abortion. The objective of this study was to investigate the allelic frequency of the single nucleotide polymorphism (SNP)c.2032G>A in the PLOD1 gene in warmblood samples from Brazil. Of the 374 Warmblood horses tested, 41 animals (11%)were identified as heterozygous for the WFFS SNP and 333 (89%)were homozygous for the wild-type allele (N/N), and therefore, the allele frequency was 5.5%. This study highlights the importance of control measures to prevent an increase in the incidence of WFFS in Warmblood horses worldwide. |
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Repositório Institucional da UNESP |
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2946 |
spelling |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in BrazilCollagenConnective tissueMutationPLOD1geneWarmblood Fragile Foal Syndrome (WFFS)is an autosomal recessive genetic disorder caused by a mutation in the procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1)gene, associated with collagen biosynthesis. WFFS causes lesions and malformations of the skin in neonatal foals, and abortion. The objective of this study was to investigate the allelic frequency of the single nucleotide polymorphism (SNP)c.2032G>A in the PLOD1 gene in warmblood samples from Brazil. Of the 374 Warmblood horses tested, 41 animals (11%)were identified as heterozygous for the WFFS SNP and 333 (89%)were homozygous for the wild-type allele (N/N), and therefore, the allele frequency was 5.5%. This study highlights the importance of control measures to prevent an increase in the incidence of WFFS in Warmblood horses worldwide.UNESP — São Paulo State University School of Veterinary Medicine and Animal Science Department of Veterinary Clinical Sciences, Rua Prof. Dr. Walter Mauricio Correa, s/nUNB — University of Brasilia Large Animal Veterinary Teaching Hospital University, Campus Darci Ribeiro - South, s/nUEL — Londrina State University Department of Veterinary Science Rodovia Celso Garcia Cid, 445, Km 380, 86.057-970Cornell University Department of Molecular MedicineUNESP — São Paulo State University Department of Microbiology and Immunology, Rua Prof. Dr. Antônio Celso Wagner Zanin, 250UNESP — São Paulo State University School of Veterinary Medicine and Animal Science Department of Veterinary Clinical Sciences, Rua Prof. Dr. Walter Mauricio Correa, s/nUNESP — São Paulo State University Department of Microbiology and Immunology, Rua Prof. Dr. Antônio Celso Wagner Zanin, 250Universidade Estadual Paulista (Unesp)UniversityUniversidade Estadual de Londrina (UEL)Cornell UniversityDias, Natalia Moraes [UNESP]de Andrade, Danilo Giorgi Abranches [UNESP]Teixeira-Neto, Antônio RaphaelTrinque, Camila MoreiraOliveira-Filho, José Paes de [UNESP]Winand, Nena J.Araújo, João Pessoa [UNESP]Borges, Alexandre Secorun [UNESP]2019-10-06T16:29:13Z2019-10-06T16:29:13Z2019-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article101-102http://dx.doi.org/10.1016/j.tvjl.2019.05.002Veterinary Journal, v. 248, p. 101-102.1532-29711090-0233http://hdl.handle.net/11449/18908210.1016/j.tvjl.2019.05.0022-s2.0-85065250212Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Journalinfo:eu-repo/semantics/openAccess2021-10-22T22:17:30Zoai:repositorio.unesp.br:11449/189082Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T22:17:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil |
title |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil |
spellingShingle |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil Dias, Natalia Moraes [UNESP] Collagen Connective tissue Mutation PLOD1gene |
title_short |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil |
title_full |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil |
title_fullStr |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil |
title_full_unstemmed |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil |
title_sort |
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil |
author |
Dias, Natalia Moraes [UNESP] |
author_facet |
Dias, Natalia Moraes [UNESP] de Andrade, Danilo Giorgi Abranches [UNESP] Teixeira-Neto, Antônio Raphael Trinque, Camila Moreira Oliveira-Filho, José Paes de [UNESP] Winand, Nena J. Araújo, João Pessoa [UNESP] Borges, Alexandre Secorun [UNESP] |
author_role |
author |
author2 |
de Andrade, Danilo Giorgi Abranches [UNESP] Teixeira-Neto, Antônio Raphael Trinque, Camila Moreira Oliveira-Filho, José Paes de [UNESP] Winand, Nena J. Araújo, João Pessoa [UNESP] Borges, Alexandre Secorun [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University Universidade Estadual de Londrina (UEL) Cornell University |
dc.contributor.author.fl_str_mv |
Dias, Natalia Moraes [UNESP] de Andrade, Danilo Giorgi Abranches [UNESP] Teixeira-Neto, Antônio Raphael Trinque, Camila Moreira Oliveira-Filho, José Paes de [UNESP] Winand, Nena J. Araújo, João Pessoa [UNESP] Borges, Alexandre Secorun [UNESP] |
dc.subject.por.fl_str_mv |
Collagen Connective tissue Mutation PLOD1gene |
topic |
Collagen Connective tissue Mutation PLOD1gene |
description |
Warmblood Fragile Foal Syndrome (WFFS)is an autosomal recessive genetic disorder caused by a mutation in the procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1)gene, associated with collagen biosynthesis. WFFS causes lesions and malformations of the skin in neonatal foals, and abortion. The objective of this study was to investigate the allelic frequency of the single nucleotide polymorphism (SNP)c.2032G>A in the PLOD1 gene in warmblood samples from Brazil. Of the 374 Warmblood horses tested, 41 animals (11%)were identified as heterozygous for the WFFS SNP and 333 (89%)were homozygous for the wild-type allele (N/N), and therefore, the allele frequency was 5.5%. This study highlights the importance of control measures to prevent an increase in the incidence of WFFS in Warmblood horses worldwide. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:29:13Z 2019-10-06T16:29:13Z 2019-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.tvjl.2019.05.002 Veterinary Journal, v. 248, p. 101-102. 1532-2971 1090-0233 http://hdl.handle.net/11449/189082 10.1016/j.tvjl.2019.05.002 2-s2.0-85065250212 |
url |
http://dx.doi.org/10.1016/j.tvjl.2019.05.002 http://hdl.handle.net/11449/189082 |
identifier_str_mv |
Veterinary Journal, v. 248, p. 101-102. 1532-2971 1090-0233 10.1016/j.tvjl.2019.05.002 2-s2.0-85065250212 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Veterinary Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
101-102 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965162793336832 |