Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice

• Autor(a) principal: Dos Santos, Amanda R. [UNESP]
• Data de Publicação: 2020
• Outros Autores: Fraga-Silva, Thais F. [UNESP], Almeida, Débora de F [UNESP], Dos Santos, Rodolfo F. [UNESP], Finato, Angela C. [UNESP], Amorim, Bárbara C [UNESP], Andrade, Maria I., Soares, Cleverson T., Lara, Vanessa S., Almeida, Nara Lm, de Arruda, Olavo S. [UNESP], de Arruda, Maria Sp [UNESP], Venturini, James [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.2217/fmb-2019-0246; http://hdl.handle.net/11449/199246
• topic: BALB/c; C57BL/6; cytokines; IL-17; Il17ra-/-; il6; immunocompetent model; intravenous infection; mucormycosis; Rhizopus oryzae; rorc; Swiss

Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra-/- mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/- mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae.