Focus on Vitamin D, Inflammation and Type 2 Diabetes
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/nu4010052 http://hdl.handle.net/11449/17410 |
Resumo: | The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes. |
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Focus on Vitamin D, Inflammation and Type 2 Diabetesvitamin DinflammationdiabetesThe initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ São Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 São Paulo, BrazilSão Paulo State Univ, Inst Biosci, Dept Educ, Ctr Nutr Practice & Res, BR-18618970 Botucatu, SP, BrazilSão Paulo State Univ, Inst Biosci, Dept Educ, Ctr Nutr Practice & Res, BR-18618970 Botucatu, SP, BrazilFAPESP: 09/54395-0FAPESP: 10/08386-7Mdpi AgUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Andrade Chagas, Carlos Eduardo [UNESP]Borges, Maria CarolinaMartini, Lgia AraujoRogero, Marcelo Macedo2014-05-20T13:48:55Z2014-05-20T13:48:55Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article52-67application/pdfhttp://dx.doi.org/10.3390/nu4010052Nutrients. Basel: Mdpi Ag, v. 4, n. 1, p. 52-67, 2012.2072-6643http://hdl.handle.net/11449/1741010.3390/nu4010052WOS:000300718000005WOS000300718000005.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNutrients4.1961,557info:eu-repo/semantics/openAccess2023-10-03T06:02:42Zoai:repositorio.unesp.br:11449/17410Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-03T06:02:42Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Focus on Vitamin D, Inflammation and Type 2 Diabetes |
title |
Focus on Vitamin D, Inflammation and Type 2 Diabetes |
spellingShingle |
Focus on Vitamin D, Inflammation and Type 2 Diabetes Andrade Chagas, Carlos Eduardo [UNESP] vitamin D inflammation diabetes |
title_short |
Focus on Vitamin D, Inflammation and Type 2 Diabetes |
title_full |
Focus on Vitamin D, Inflammation and Type 2 Diabetes |
title_fullStr |
Focus on Vitamin D, Inflammation and Type 2 Diabetes |
title_full_unstemmed |
Focus on Vitamin D, Inflammation and Type 2 Diabetes |
title_sort |
Focus on Vitamin D, Inflammation and Type 2 Diabetes |
author |
Andrade Chagas, Carlos Eduardo [UNESP] |
author_facet |
Andrade Chagas, Carlos Eduardo [UNESP] Borges, Maria Carolina Martini, Lgia Araujo Rogero, Marcelo Macedo |
author_role |
author |
author2 |
Borges, Maria Carolina Martini, Lgia Araujo Rogero, Marcelo Macedo |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Andrade Chagas, Carlos Eduardo [UNESP] Borges, Maria Carolina Martini, Lgia Araujo Rogero, Marcelo Macedo |
dc.subject.por.fl_str_mv |
vitamin D inflammation diabetes |
topic |
vitamin D inflammation diabetes |
description |
The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T13:48:55Z 2014-05-20T13:48:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/nu4010052 Nutrients. Basel: Mdpi Ag, v. 4, n. 1, p. 52-67, 2012. 2072-6643 http://hdl.handle.net/11449/17410 10.3390/nu4010052 WOS:000300718000005 WOS000300718000005.pdf |
url |
http://dx.doi.org/10.3390/nu4010052 http://hdl.handle.net/11449/17410 |
identifier_str_mv |
Nutrients. Basel: Mdpi Ag, v. 4, n. 1, p. 52-67, 2012. 2072-6643 10.3390/nu4010052 WOS:000300718000005 WOS000300718000005.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrients 4.196 1,557 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
52-67 application/pdf |
dc.publisher.none.fl_str_mv |
Mdpi Ag |
publisher.none.fl_str_mv |
Mdpi Ag |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964413722099712 |