Guidelines for the management and treatment of periodic fever syndromes Familial Mediterranean Fever

• Autor(a) principal: Terreri, Maria Teresa R A
• Data de Publicação: 2015
• Outros Autores: Bernardo, Wanderley Marques, Len, Claudio Arnaldo, Silva, Clovis Artur Almeida da, Magalhães, Cristina Medeiros Ribeiro de, Sacchetti, Silvana B., Ferriani, Virgínia Paes Leme, Piotto, Daniela Gerent Petry, Cavalcanti, André de Souza, Moraes, Ana Júlia Pantoja de, Sztajnbok, Flavio Roberto, Oliveira, Sheila Knupp Feitosa de, Campos, Lucia Maria Arruda, Bandeira, Marcia, Santos, Flávia Patricia Sena Teixeira, Magalhães, Claudia Saad [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.rbr.2015.08.006; http://hdl.handle.net/11449/131634
• topic: Autoinflammatory syndromes; Childhood; Diretrizes; Familial mediterranean fever; Febre; Febre familiar do mediterrâneo; Fever; Guidelines; Infância; Síndromes autoinflamatórias

To establish guidelines based on scientific evidence for the management of familial Mediterranean fever. The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 10,341 articles were retrieved and evaluated by title and abstract; from these, 46 articles were selected to support the recommendations. 1. The diagnosis of FMF is based on clinical manifestations, characterized by recurrent febrile episodes associated with abdominal pain, chest or arthritis of large joints; 2. FMF is a genetic disease presenting an autosomal recessive trait, caused by mutation in the MEFV gene; 3. Laboratory tests are not specific, demonstrating high serum levels of inflammatory proteins in the acute phase of the disease, but also often showing high levels even between attacks. SAA serum levels may be especially useful in monitoring the effectiveness of treatment; 4. The therapy of choice is colchicine; this drug has proven effectiveness in preventing acute inflammatory episodes and progression towards amyloidosis in adults; 5. Based on the available information, the use of biological drugs appears to be an alternative for patients with FMF who do not respond or are intolerant to therapy with colchicine.