Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women

Detalhes bibliográficos
Autor(a) principal: Zaros, Pedro R. [UNESP]
Data de Publicação: 2009
Outros Autores: Pires, Carla E.M. Romero [UNESP], Bacci Jr., Mauricio [UNESP], Moraes, Camila, Zanesco, Angelina [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/1472-6874-9-17
http://hdl.handle.net/11449/71040
Resumo: Background: Evidences have showed that the incidence of arterial hypertension is greater in postmenopausal women as compared to premenopausal. Physical inactivity has been implicated as a major contributor to weight gain and abdominal obesity in postmenopausal women and the incidence of cardiovascular disease increases dramatically after menopause. Additionally, more women than men die each year of coronary heart disease and are twice as likely as men to die within the first year after a heart attack. A healthy lifestyle has been strongly associated with the regular physical activity and evidences have shown that physically active subjects have more longevity with reduction of morbidity and mortality. Nitric oxide (NO) produced by endothelial cells has been implicated in this beneficial effect with improvement of vascular relaxing and reduction in blood pressure in both laboratory animals and human. Although the effect of exercise training in the human cardiovascular system has been largely studied, the majority of these studies were predominantly conducted in men or young volunteers. Therefore, the aim of this work was to investigate the effects of 6 months of dynamic exercise training (ET) on blood pressure and plasma nitrate/nitrite concentration (NOx-) in hypertensive postmenopausal women. Methods: Eleven volunteers were submitted to the ET consisting in 3 days a week, each session of 60 minutes during 6 months at moderate intensity (50% of heart rate reserve). Anthropometric parameters, blood pressure, NOx- concentration were measured at initial time and after ET. Results: A significant reduction in both systolic and diastolic blood pressure values was seen after ET which was accompanied by markedly increase of NOx- levels (basal: 10 ± 0.9; ET: 16 ± 2 μM). Total cholesterol was significantly reduced (basal: 220 ± 38 and ET: 178 ± 22 mg/dl), whereas triglycerides levels were not modified after ET (basal: 141 ± 89 and ET: 147 ± 8 mg/dl). Conclusion: Our study shows that changing in lifestyle promotes reducftion of arterial pressure which was accompanied by increase in nitrite/nitrate concentration. Therefore, 6-months of exercise training are an important approach in management arterial hypertension and play a protective effect in postmenopausal women. © 2009 Zaros et al; licensee BioMed Central Ltd.
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spelling Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal womennitratenitric oxidetriacylglycerolcholesterolnitriteadultanthropometryblood pressure monitoringbody masscholesterol blood levelclinical articlediastolic blood pressuredynamic exerciseenzyme blood levelfemaleglucose blood levelheart ratehumanhypertensionpostmenopausesystolic blood pressuretreatment durationtreatment responsetriacylglycerol blood levelwaist hip ratiobloodblood pressureclinical trialkinesiotherapymethodologymiddle agedtreatment outcomeBlood PressureBody Mass IndexCholesterolExercise TherapyFemaleHeart RateHumansHypertensionMiddle AgedNitratesNitritesPostmenopauseTreatment OutcomeBackground: Evidences have showed that the incidence of arterial hypertension is greater in postmenopausal women as compared to premenopausal. Physical inactivity has been implicated as a major contributor to weight gain and abdominal obesity in postmenopausal women and the incidence of cardiovascular disease increases dramatically after menopause. Additionally, more women than men die each year of coronary heart disease and are twice as likely as men to die within the first year after a heart attack. A healthy lifestyle has been strongly associated with the regular physical activity and evidences have shown that physically active subjects have more longevity with reduction of morbidity and mortality. Nitric oxide (NO) produced by endothelial cells has been implicated in this beneficial effect with improvement of vascular relaxing and reduction in blood pressure in both laboratory animals and human. Although the effect of exercise training in the human cardiovascular system has been largely studied, the majority of these studies were predominantly conducted in men or young volunteers. Therefore, the aim of this work was to investigate the effects of 6 months of dynamic exercise training (ET) on blood pressure and plasma nitrate/nitrite concentration (NOx-) in hypertensive postmenopausal women. Methods: Eleven volunteers were submitted to the ET consisting in 3 days a week, each session of 60 minutes during 6 months at moderate intensity (50% of heart rate reserve). Anthropometric parameters, blood pressure, NOx- concentration were measured at initial time and after ET. Results: A significant reduction in both systolic and diastolic blood pressure values was seen after ET which was accompanied by markedly increase of NOx- levels (basal: 10 ± 0.9; ET: 16 ± 2 μM). Total cholesterol was significantly reduced (basal: 220 ± 38 and ET: 178 ± 22 mg/dl), whereas triglycerides levels were not modified after ET (basal: 141 ± 89 and ET: 147 ± 8 mg/dl). Conclusion: Our study shows that changing in lifestyle promotes reducftion of arterial pressure which was accompanied by increase in nitrite/nitrate concentration. Therefore, 6-months of exercise training are an important approach in management arterial hypertension and play a protective effect in postmenopausal women. © 2009 Zaros et al; licensee BioMed Central Ltd.Department of Physical Education Institute of Biosciences University of Sao Paulo State (UNESP), Rio Claro, SPDepartmento of Biochemistry University of Sao Paulo State (UNESP), Rio Claro, SPInstitute of Physical Activity and Sports Cruzeiro do Sul University, Sao Paulo, SPDepartment of Physical Education Institute of Biosciences University of Sao Paulo State (UNESP), Rio Claro, SPDepartmento of Biochemistry University of Sao Paulo State (UNESP), Rio Claro, SPUniversidade Estadual Paulista (Unesp)Cruzeiro do Sul UniversityZaros, Pedro R. [UNESP]Pires, Carla E.M. Romero [UNESP]Bacci Jr., Mauricio [UNESP]Moraes, CamilaZanesco, Angelina [UNESP]2014-05-27T11:23:55Z2014-05-27T11:23:55Z2009-06-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/1472-6874-9-17BMC Women's Health, v. 9.1472-6874http://hdl.handle.net/11449/7104010.1186/1472-6874-9-172-s2.0-682491566032-s2.0-68249156603.pdf4472007237545596Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Women's Health1.8060,931info:eu-repo/semantics/openAccess2024-01-11T06:27:53Zoai:repositorio.unesp.br:11449/71040Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:41:31.560204Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women
title Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women
spellingShingle Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women
Zaros, Pedro R. [UNESP]
nitrate
nitric oxide
triacylglycerol
cholesterol
nitrite
adult
anthropometry
blood pressure monitoring
body mass
cholesterol blood level
clinical article
diastolic blood pressure
dynamic exercise
enzyme blood level
female
glucose blood level
heart rate
human
hypertension
postmenopause
systolic blood pressure
treatment duration
treatment response
triacylglycerol blood level
waist hip ratio
blood
blood pressure
clinical trial
kinesiotherapy
methodology
middle aged
treatment outcome
Blood Pressure
Body Mass Index
Cholesterol
Exercise Therapy
Female
Heart Rate
Humans
Hypertension
Middle Aged
Nitrates
Nitrites
Postmenopause
Treatment Outcome
title_short Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women
title_full Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women
title_fullStr Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women
title_full_unstemmed Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women
title_sort Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women
author Zaros, Pedro R. [UNESP]
author_facet Zaros, Pedro R. [UNESP]
Pires, Carla E.M. Romero [UNESP]
Bacci Jr., Mauricio [UNESP]
Moraes, Camila
Zanesco, Angelina [UNESP]
author_role author
author2 Pires, Carla E.M. Romero [UNESP]
Bacci Jr., Mauricio [UNESP]
Moraes, Camila
Zanesco, Angelina [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Cruzeiro do Sul University
dc.contributor.author.fl_str_mv Zaros, Pedro R. [UNESP]
Pires, Carla E.M. Romero [UNESP]
Bacci Jr., Mauricio [UNESP]
Moraes, Camila
Zanesco, Angelina [UNESP]
dc.subject.por.fl_str_mv nitrate
nitric oxide
triacylglycerol
cholesterol
nitrite
adult
anthropometry
blood pressure monitoring
body mass
cholesterol blood level
clinical article
diastolic blood pressure
dynamic exercise
enzyme blood level
female
glucose blood level
heart rate
human
hypertension
postmenopause
systolic blood pressure
treatment duration
treatment response
triacylglycerol blood level
waist hip ratio
blood
blood pressure
clinical trial
kinesiotherapy
methodology
middle aged
treatment outcome
Blood Pressure
Body Mass Index
Cholesterol
Exercise Therapy
Female
Heart Rate
Humans
Hypertension
Middle Aged
Nitrates
Nitrites
Postmenopause
Treatment Outcome
topic nitrate
nitric oxide
triacylglycerol
cholesterol
nitrite
adult
anthropometry
blood pressure monitoring
body mass
cholesterol blood level
clinical article
diastolic blood pressure
dynamic exercise
enzyme blood level
female
glucose blood level
heart rate
human
hypertension
postmenopause
systolic blood pressure
treatment duration
treatment response
triacylglycerol blood level
waist hip ratio
blood
blood pressure
clinical trial
kinesiotherapy
methodology
middle aged
treatment outcome
Blood Pressure
Body Mass Index
Cholesterol
Exercise Therapy
Female
Heart Rate
Humans
Hypertension
Middle Aged
Nitrates
Nitrites
Postmenopause
Treatment Outcome
description Background: Evidences have showed that the incidence of arterial hypertension is greater in postmenopausal women as compared to premenopausal. Physical inactivity has been implicated as a major contributor to weight gain and abdominal obesity in postmenopausal women and the incidence of cardiovascular disease increases dramatically after menopause. Additionally, more women than men die each year of coronary heart disease and are twice as likely as men to die within the first year after a heart attack. A healthy lifestyle has been strongly associated with the regular physical activity and evidences have shown that physically active subjects have more longevity with reduction of morbidity and mortality. Nitric oxide (NO) produced by endothelial cells has been implicated in this beneficial effect with improvement of vascular relaxing and reduction in blood pressure in both laboratory animals and human. Although the effect of exercise training in the human cardiovascular system has been largely studied, the majority of these studies were predominantly conducted in men or young volunteers. Therefore, the aim of this work was to investigate the effects of 6 months of dynamic exercise training (ET) on blood pressure and plasma nitrate/nitrite concentration (NOx-) in hypertensive postmenopausal women. Methods: Eleven volunteers were submitted to the ET consisting in 3 days a week, each session of 60 minutes during 6 months at moderate intensity (50% of heart rate reserve). Anthropometric parameters, blood pressure, NOx- concentration were measured at initial time and after ET. Results: A significant reduction in both systolic and diastolic blood pressure values was seen after ET which was accompanied by markedly increase of NOx- levels (basal: 10 ± 0.9; ET: 16 ± 2 μM). Total cholesterol was significantly reduced (basal: 220 ± 38 and ET: 178 ± 22 mg/dl), whereas triglycerides levels were not modified after ET (basal: 141 ± 89 and ET: 147 ± 8 mg/dl). Conclusion: Our study shows that changing in lifestyle promotes reducftion of arterial pressure which was accompanied by increase in nitrite/nitrate concentration. Therefore, 6-months of exercise training are an important approach in management arterial hypertension and play a protective effect in postmenopausal women. © 2009 Zaros et al; licensee BioMed Central Ltd.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-19
2014-05-27T11:23:55Z
2014-05-27T11:23:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/1472-6874-9-17
BMC Women's Health, v. 9.
1472-6874
http://hdl.handle.net/11449/71040
10.1186/1472-6874-9-17
2-s2.0-68249156603
2-s2.0-68249156603.pdf
4472007237545596
url http://dx.doi.org/10.1186/1472-6874-9-17
http://hdl.handle.net/11449/71040
identifier_str_mv BMC Women's Health, v. 9.
1472-6874
10.1186/1472-6874-9-17
2-s2.0-68249156603
2-s2.0-68249156603.pdf
4472007237545596
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Women's Health
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reponame:Repositório Institucional da UNESP
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instname_str Universidade Estadual Paulista (UNESP)
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reponame_str Repositório Institucional da UNESP
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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