Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil)
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00414-018-01988-w http://hdl.handle.net/11449/189681 |
Resumo: | X-chromosomal markers can be useful in some forensic cases, where the analysis of the autosomal markers is not conclusive. In this study, a population sample of 500 unrelated individuals born in São Paulo State was characterized for 32 X-InDel markers. No deviations from the Hardy–Weinberg equilibrium were detected, except for MID1361. The 32 X-InDels showed an accumulated power of discrimination of 0.9999999999993 in females and 0.99999993 in males and an exclusion chance of 0.999996 in trios and 0.99995 in duos. São Paulo showed lower genetic distances to the Colombian admixed and European populations than to Native American, Asian, or African populations. Ancestry analysis revealed 41.8% European, 31.6% African, and 26.6% Native American contributions. Segregation analysis was performed in 101 trios, and the mutation rate was estimated to be low. |
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Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil)Forensic geneticsHuman identificationInsertion/deletion polymorphismKinship testingX chromosomeX-chromosomal markers can be useful in some forensic cases, where the analysis of the autosomal markers is not conclusive. In this study, a population sample of 500 unrelated individuals born in São Paulo State was characterized for 32 X-InDel markers. No deviations from the Hardy–Weinberg equilibrium were detected, except for MID1361. The 32 X-InDels showed an accumulated power of discrimination of 0.9999999999993 in females and 0.99999993 in males and an exclusion chance of 0.999996 in trios and 0.99995 in duos. São Paulo showed lower genetic distances to the Colombian admixed and European populations than to Native American, Asian, or African populations. Ancestry analysis revealed 41.8% European, 31.6% African, and 26.6% Native American contributions. Segregation analysis was performed in 101 trios, and the mutation rate was estimated to be low.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Laboratory of Paternity Investigation School of Pharmaceutical Sciences São Paulo State University (UNESP)Research Centre for Biochemistry and Molecular Biology Medical School of São José do Rio Preto (FAMERP)DNA Diagnostic Laboratory (LDD) State University of Rio de Janeiro (UERJ)Laboratory of Paternity Investigation School of Pharmaceutical Sciences São Paulo State University (UNESP)FAPESP: 16/10138-8CAPES: numberUniversidade Estadual Paulista (Unesp)Medical School of São José do Rio Preto (FAMERP)Universidade do Estado do Rio de Janeiro (UERJ)Martinez, Juliana [UNESP]Polverari, Fernanda Silva [UNESP]Silva, Flávia Alves de Jesus [UNESP]Braganholi, Danilo Faustino [UNESP]Ferraz, Joyce Aparecida Martins LopesGusmão, LeonorCicarelli, Regina Maria Barretto [UNESP]2019-10-06T16:48:41Z2019-10-06T16:48:41Z2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1385-1388http://dx.doi.org/10.1007/s00414-018-01988-wInternational Journal of Legal Medicine, v. 133, n. 5, p. 1385-1388, 2019.1437-15960937-9827http://hdl.handle.net/11449/18968110.1007/s00414-018-01988-w2-s2.0-85059548915Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Legal Medicineinfo:eu-repo/semantics/openAccess2021-10-23T15:55:12Zoai:repositorio.unesp.br:11449/189681Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:06:08.103396Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil) |
title |
Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil) |
spellingShingle |
Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil) Martinez, Juliana [UNESP] Forensic genetics Human identification Insertion/deletion polymorphism Kinship testing X chromosome |
title_short |
Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil) |
title_full |
Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil) |
title_fullStr |
Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil) |
title_full_unstemmed |
Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil) |
title_sort |
Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil) |
author |
Martinez, Juliana [UNESP] |
author_facet |
Martinez, Juliana [UNESP] Polverari, Fernanda Silva [UNESP] Silva, Flávia Alves de Jesus [UNESP] Braganholi, Danilo Faustino [UNESP] Ferraz, Joyce Aparecida Martins Lopes Gusmão, Leonor Cicarelli, Regina Maria Barretto [UNESP] |
author_role |
author |
author2 |
Polverari, Fernanda Silva [UNESP] Silva, Flávia Alves de Jesus [UNESP] Braganholi, Danilo Faustino [UNESP] Ferraz, Joyce Aparecida Martins Lopes Gusmão, Leonor Cicarelli, Regina Maria Barretto [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Medical School of São José do Rio Preto (FAMERP) Universidade do Estado do Rio de Janeiro (UERJ) |
dc.contributor.author.fl_str_mv |
Martinez, Juliana [UNESP] Polverari, Fernanda Silva [UNESP] Silva, Flávia Alves de Jesus [UNESP] Braganholi, Danilo Faustino [UNESP] Ferraz, Joyce Aparecida Martins Lopes Gusmão, Leonor Cicarelli, Regina Maria Barretto [UNESP] |
dc.subject.por.fl_str_mv |
Forensic genetics Human identification Insertion/deletion polymorphism Kinship testing X chromosome |
topic |
Forensic genetics Human identification Insertion/deletion polymorphism Kinship testing X chromosome |
description |
X-chromosomal markers can be useful in some forensic cases, where the analysis of the autosomal markers is not conclusive. In this study, a population sample of 500 unrelated individuals born in São Paulo State was characterized for 32 X-InDel markers. No deviations from the Hardy–Weinberg equilibrium were detected, except for MID1361. The 32 X-InDels showed an accumulated power of discrimination of 0.9999999999993 in females and 0.99999993 in males and an exclusion chance of 0.999996 in trios and 0.99995 in duos. São Paulo showed lower genetic distances to the Colombian admixed and European populations than to Native American, Asian, or African populations. Ancestry analysis revealed 41.8% European, 31.6% African, and 26.6% Native American contributions. Segregation analysis was performed in 101 trios, and the mutation rate was estimated to be low. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:48:41Z 2019-10-06T16:48:41Z 2019-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00414-018-01988-w International Journal of Legal Medicine, v. 133, n. 5, p. 1385-1388, 2019. 1437-1596 0937-9827 http://hdl.handle.net/11449/189681 10.1007/s00414-018-01988-w 2-s2.0-85059548915 |
url |
http://dx.doi.org/10.1007/s00414-018-01988-w http://hdl.handle.net/11449/189681 |
identifier_str_mv |
International Journal of Legal Medicine, v. 133, n. 5, p. 1385-1388, 2019. 1437-1596 0937-9827 10.1007/s00414-018-01988-w 2-s2.0-85059548915 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Legal Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1385-1388 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128894191009792 |