From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.scitotenv.2022.157332 http://hdl.handle.net/11449/240539 |
Resumo: | Sediments represent a major sink and also a main source of contaminants to aquatic environments. An environmental disaster from a mining dam breakage in 2015 in South-East Brazil re-suspended complex mixtures of chemicals deposited in the sediment, spreading contaminants along the Doce River Basin (DRB) major river course. While high levels of contaminants in sediment were well described, toxicological effects in aquatic organisms were poorly investigated. Thus, the effects of these potentially toxic chemicals were assessed in the present study through different endpoints (biochemical to populational levels) in fish embryos of the South-American silver catfish exposed to elutriates from different sites of the DRB. Despite no significant mortality observed, our results showed that exposure to the elutriates, especially those from the closest site to the dam collapse, caused higher deformities rates and DNA damage in the fish embryos than in the control group. Multivariate analysis showed that these sublethal effects may be related to the high levels of metals introduced by mining activities, compromising long-term survival and reproduction success. In addition, it was possible to observe the influence of other sources of pollutants along the river. According to our data, the mathematical model simulated a significant impact on the population density at longer-term exposure, for the sites that showed the most prominent toxicity responses. The fish embryo toxicity test proved to be an effective assay to assess the ecotoxicological effects of the pollutants from a major river contaminated by a mining dam collapse and showed that the survival rate per se was not a suitable endpoint to assess the toxicity of the pollutants. As a consequence, we contributed to shed a light on a potential underestimated impact of pollutants in sediments of the DRB on the native organisms at distinct biological levels of organizations. |
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From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce RiverBiomarkersMining activitiesModelingSedimentsSublethal effectsToxicity testSediments represent a major sink and also a main source of contaminants to aquatic environments. An environmental disaster from a mining dam breakage in 2015 in South-East Brazil re-suspended complex mixtures of chemicals deposited in the sediment, spreading contaminants along the Doce River Basin (DRB) major river course. While high levels of contaminants in sediment were well described, toxicological effects in aquatic organisms were poorly investigated. Thus, the effects of these potentially toxic chemicals were assessed in the present study through different endpoints (biochemical to populational levels) in fish embryos of the South-American silver catfish exposed to elutriates from different sites of the DRB. Despite no significant mortality observed, our results showed that exposure to the elutriates, especially those from the closest site to the dam collapse, caused higher deformities rates and DNA damage in the fish embryos than in the control group. Multivariate analysis showed that these sublethal effects may be related to the high levels of metals introduced by mining activities, compromising long-term survival and reproduction success. In addition, it was possible to observe the influence of other sources of pollutants along the river. According to our data, the mathematical model simulated a significant impact on the population density at longer-term exposure, for the sites that showed the most prominent toxicity responses. The fish embryo toxicity test proved to be an effective assay to assess the ecotoxicological effects of the pollutants from a major river contaminated by a mining dam collapse and showed that the survival rate per se was not a suitable endpoint to assess the toxicity of the pollutants. As a consequence, we contributed to shed a light on a potential underestimated impact of pollutants in sediments of the DRB on the native organisms at distinct biological levels of organizations.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Fundação de Amparo à Pesquisa e Inovação do Espírito SantoFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Agência Nacional de ÁguasInstitute of Biosciences São Paulo State UniversityGraduation Program in Ecology and Conservation Federal University of ParanáDepartment of Chemistry and Biology Federal University of Technology-ParanáPanama Fish FarmAnalyses and Synthesis in Biodiversity Lab Botany Department Federal University CuritibaInstitute of Biosciences São Paulo State UniversityFAPESP: 2016/15229-1Agência Nacional de Águas: 23038.028816/2016-41CNPq: 308533/2018-6CNPq: 308648/2021-8Universidade Estadual Paulista (UNESP)Federal University of ParanáFederal University of Technology-ParanáPanama Fish FarmFederal University CuritibaYamamoto, Flávia Yoshie [UNESP]Souza, Angie Thaisa CostaPaula, Vinicius de Carvalho Soares deBeverari, Isabella [UNESP]Garcia, Juan Ramon EsquivelPadial, André AndianAbessa, Denis Moledo de Souza [UNESP]2023-03-01T20:21:44Z2023-03-01T20:21:44Z2022-11-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.scitotenv.2022.157332Science of the Total Environment, v. 846.1879-10260048-9697http://hdl.handle.net/11449/24053910.1016/j.scitotenv.2022.1573322-s2.0-85134880884Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScience of the Total Environmentinfo:eu-repo/semantics/openAccess2023-03-01T20:21:44Zoai:repositorio.unesp.br:11449/240539Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:28:51.513910Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River |
title |
From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River |
spellingShingle |
From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River Yamamoto, Flávia Yoshie [UNESP] Biomarkers Mining activities Modeling Sediments Sublethal effects Toxicity test |
title_short |
From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River |
title_full |
From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River |
title_fullStr |
From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River |
title_full_unstemmed |
From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River |
title_sort |
From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River |
author |
Yamamoto, Flávia Yoshie [UNESP] |
author_facet |
Yamamoto, Flávia Yoshie [UNESP] Souza, Angie Thaisa Costa Paula, Vinicius de Carvalho Soares de Beverari, Isabella [UNESP] Garcia, Juan Ramon Esquivel Padial, André Andian Abessa, Denis Moledo de Souza [UNESP] |
author_role |
author |
author2 |
Souza, Angie Thaisa Costa Paula, Vinicius de Carvalho Soares de Beverari, Isabella [UNESP] Garcia, Juan Ramon Esquivel Padial, André Andian Abessa, Denis Moledo de Souza [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Federal University of Paraná Federal University of Technology-Paraná Panama Fish Farm Federal University Curitiba |
dc.contributor.author.fl_str_mv |
Yamamoto, Flávia Yoshie [UNESP] Souza, Angie Thaisa Costa Paula, Vinicius de Carvalho Soares de Beverari, Isabella [UNESP] Garcia, Juan Ramon Esquivel Padial, André Andian Abessa, Denis Moledo de Souza [UNESP] |
dc.subject.por.fl_str_mv |
Biomarkers Mining activities Modeling Sediments Sublethal effects Toxicity test |
topic |
Biomarkers Mining activities Modeling Sediments Sublethal effects Toxicity test |
description |
Sediments represent a major sink and also a main source of contaminants to aquatic environments. An environmental disaster from a mining dam breakage in 2015 in South-East Brazil re-suspended complex mixtures of chemicals deposited in the sediment, spreading contaminants along the Doce River Basin (DRB) major river course. While high levels of contaminants in sediment were well described, toxicological effects in aquatic organisms were poorly investigated. Thus, the effects of these potentially toxic chemicals were assessed in the present study through different endpoints (biochemical to populational levels) in fish embryos of the South-American silver catfish exposed to elutriates from different sites of the DRB. Despite no significant mortality observed, our results showed that exposure to the elutriates, especially those from the closest site to the dam collapse, caused higher deformities rates and DNA damage in the fish embryos than in the control group. Multivariate analysis showed that these sublethal effects may be related to the high levels of metals introduced by mining activities, compromising long-term survival and reproduction success. In addition, it was possible to observe the influence of other sources of pollutants along the river. According to our data, the mathematical model simulated a significant impact on the population density at longer-term exposure, for the sites that showed the most prominent toxicity responses. The fish embryo toxicity test proved to be an effective assay to assess the ecotoxicological effects of the pollutants from a major river contaminated by a mining dam collapse and showed that the survival rate per se was not a suitable endpoint to assess the toxicity of the pollutants. As a consequence, we contributed to shed a light on a potential underestimated impact of pollutants in sediments of the DRB on the native organisms at distinct biological levels of organizations. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-10 2023-03-01T20:21:44Z 2023-03-01T20:21:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.scitotenv.2022.157332 Science of the Total Environment, v. 846. 1879-1026 0048-9697 http://hdl.handle.net/11449/240539 10.1016/j.scitotenv.2022.157332 2-s2.0-85134880884 |
url |
http://dx.doi.org/10.1016/j.scitotenv.2022.157332 http://hdl.handle.net/11449/240539 |
identifier_str_mv |
Science of the Total Environment, v. 846. 1879-1026 0048-9697 10.1016/j.scitotenv.2022.157332 2-s2.0-85134880884 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Science of the Total Environment |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128365730725888 |