Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.pdpdt.2019.05.037 http://hdl.handle.net/11449/189217 |
Resumo: | Background: Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating complication strongly associated to antiresorptive agents. The present study aimed to describe the use of antimicrobial photodynamic therapy (aPDT) in the prevention of MRONJ. Methods: The sample consisted of 11 non-oncologic osteoporotic subjects in therapy with non-intravenous antiresorptive agents, requiring tooth extractions and/or implant removal. After minimally invasive surgical extractions, each alveolar socket was debrided and bony edges were smoothened. At this point, aPDT was performed using methylene blue-based phenothiazine chloride dye irradiated with a hand-held 100 mW diode laser with a wavelength of 660 ± 10 nm. Flaps were sutured to achieve first intention closure. Soft tissue healing was promoted with weekly applications of low-level laser therapy for 6 weeks. Recall visits were scheduled weekly for the first two months and monthly thereafter up to 6 months. At the 6-month appointment, healing was assessed clinically and radiographically. Results: A total of 62 surgical extractions were performed in both jaws, including 51 natural elements and 11 dental implants. No intraoperative complications were observed. Immediate post-operative period was generally uneventful except for mild pain and ecchymosis that occurred rarely and resolved spontaneously. Healing proceeded uneventfully, with no clinical or radiological prodromal manifestations of MRONJ up to the latest follow-up visit. Conclusions: aPDT might constitute a promising preventive treatment to reduce the risk of MRONJ in non-oncologic osteoporotic patients treated with non-intravenous antiresorptive agents that underwent dentoalveolar surgery. |
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Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case seriesAntimicrobial photodynamic therapyAntiresorptive agentsDentoalveolar surgeryOsteonecrosisPeri-implantitisBackground: Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating complication strongly associated to antiresorptive agents. The present study aimed to describe the use of antimicrobial photodynamic therapy (aPDT) in the prevention of MRONJ. Methods: The sample consisted of 11 non-oncologic osteoporotic subjects in therapy with non-intravenous antiresorptive agents, requiring tooth extractions and/or implant removal. After minimally invasive surgical extractions, each alveolar socket was debrided and bony edges were smoothened. At this point, aPDT was performed using methylene blue-based phenothiazine chloride dye irradiated with a hand-held 100 mW diode laser with a wavelength of 660 ± 10 nm. Flaps were sutured to achieve first intention closure. Soft tissue healing was promoted with weekly applications of low-level laser therapy for 6 weeks. Recall visits were scheduled weekly for the first two months and monthly thereafter up to 6 months. At the 6-month appointment, healing was assessed clinically and radiographically. Results: A total of 62 surgical extractions were performed in both jaws, including 51 natural elements and 11 dental implants. No intraoperative complications were observed. Immediate post-operative period was generally uneventful except for mild pain and ecchymosis that occurred rarely and resolved spontaneously. Healing proceeded uneventfully, with no clinical or radiological prodromal manifestations of MRONJ up to the latest follow-up visit. Conclusions: aPDT might constitute a promising preventive treatment to reduce the risk of MRONJ in non-oncologic osteoporotic patients treated with non-intravenous antiresorptive agents that underwent dentoalveolar surgery.Implant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico University of Milan, Via Commenda 10Department of Surgery and Integrated Clinic Araçatuba Dental School São Paulo State University “Júlio de Mesquita Filho” UNESP, Rua José Bonifácio, 1193 - Vila MendoncaSchool of Dentistry Department of Biomedical Surgical and Dental Sciences University of Milan, Via della Commenda 10Department of Surgery and Integrated Clinic Araçatuba Dental School São Paulo State University “Júlio de Mesquita Filho” UNESP, Rua José Bonifácio, 1193 - Vila MendoncaUniversity of MilanUniversidade Estadual Paulista (Unesp)Poli, Pier PaoloSouza, Francisley Ávila [UNESP]Ferrario, SusannaMaiorana, Carlo2019-10-06T16:33:41Z2019-10-06T16:33:41Z2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article117-123http://dx.doi.org/10.1016/j.pdpdt.2019.05.037Photodiagnosis and Photodynamic Therapy, v. 27, p. 117-123.1873-15971572-1000http://hdl.handle.net/11449/18921710.1016/j.pdpdt.2019.05.0372-s2.0-85066865344Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhotodiagnosis and Photodynamic Therapyinfo:eu-repo/semantics/openAccess2021-10-22T21:16:11Zoai:repositorio.unesp.br:11449/189217Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:16:15.157635Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series |
title |
Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series |
spellingShingle |
Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series Poli, Pier Paolo Antimicrobial photodynamic therapy Antiresorptive agents Dentoalveolar surgery Osteonecrosis Peri-implantitis |
title_short |
Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series |
title_full |
Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series |
title_fullStr |
Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series |
title_full_unstemmed |
Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series |
title_sort |
Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: A case series |
author |
Poli, Pier Paolo |
author_facet |
Poli, Pier Paolo Souza, Francisley Ávila [UNESP] Ferrario, Susanna Maiorana, Carlo |
author_role |
author |
author2 |
Souza, Francisley Ávila [UNESP] Ferrario, Susanna Maiorana, Carlo |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
University of Milan Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Poli, Pier Paolo Souza, Francisley Ávila [UNESP] Ferrario, Susanna Maiorana, Carlo |
dc.subject.por.fl_str_mv |
Antimicrobial photodynamic therapy Antiresorptive agents Dentoalveolar surgery Osteonecrosis Peri-implantitis |
topic |
Antimicrobial photodynamic therapy Antiresorptive agents Dentoalveolar surgery Osteonecrosis Peri-implantitis |
description |
Background: Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating complication strongly associated to antiresorptive agents. The present study aimed to describe the use of antimicrobial photodynamic therapy (aPDT) in the prevention of MRONJ. Methods: The sample consisted of 11 non-oncologic osteoporotic subjects in therapy with non-intravenous antiresorptive agents, requiring tooth extractions and/or implant removal. After minimally invasive surgical extractions, each alveolar socket was debrided and bony edges were smoothened. At this point, aPDT was performed using methylene blue-based phenothiazine chloride dye irradiated with a hand-held 100 mW diode laser with a wavelength of 660 ± 10 nm. Flaps were sutured to achieve first intention closure. Soft tissue healing was promoted with weekly applications of low-level laser therapy for 6 weeks. Recall visits were scheduled weekly for the first two months and monthly thereafter up to 6 months. At the 6-month appointment, healing was assessed clinically and radiographically. Results: A total of 62 surgical extractions were performed in both jaws, including 51 natural elements and 11 dental implants. No intraoperative complications were observed. Immediate post-operative period was generally uneventful except for mild pain and ecchymosis that occurred rarely and resolved spontaneously. Healing proceeded uneventfully, with no clinical or radiological prodromal manifestations of MRONJ up to the latest follow-up visit. Conclusions: aPDT might constitute a promising preventive treatment to reduce the risk of MRONJ in non-oncologic osteoporotic patients treated with non-intravenous antiresorptive agents that underwent dentoalveolar surgery. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:33:41Z 2019-10-06T16:33:41Z 2019-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.pdpdt.2019.05.037 Photodiagnosis and Photodynamic Therapy, v. 27, p. 117-123. 1873-1597 1572-1000 http://hdl.handle.net/11449/189217 10.1016/j.pdpdt.2019.05.037 2-s2.0-85066865344 |
url |
http://dx.doi.org/10.1016/j.pdpdt.2019.05.037 http://hdl.handle.net/11449/189217 |
identifier_str_mv |
Photodiagnosis and Photodynamic Therapy, v. 27, p. 117-123. 1873-1597 1572-1000 10.1016/j.pdpdt.2019.05.037 2-s2.0-85066865344 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Photodiagnosis and Photodynamic Therapy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
117-123 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128338354503680 |