Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.2217/nnm-2021-0229 http://hdl.handle.net/11449/234097 |
Resumo: | Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media. |
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Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cellscancercolloidcolon adenocarcinomadrug deliverymurumuru butterAim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.Laboratory of Nanoscience and Immunology Faculty of Ceilandia University of Brasilia, DFDepartment of Genetics and Morphology Institute of Biological Sciences University of BrasiliaSoft Matter Laboratory Center for Cooperative Research in Biomaterials (CIC BiomaGUNE)School of Biosciences The University of MelbourneLaboratory of Thermal Analysis Ivo Giolitto Chemical Institute São Paulo State University São Paulo, SPUniversity of Campinas (UNICAMP), São PauloSchool of Pharmaceutical Sciences São Paulo State University (UNESP)Laboratory of Thermal Analysis Ivo Giolitto Chemical Institute São Paulo State University São Paulo, SPSchool of Pharmaceutical Sciences São Paulo State University (UNESP)University of BrasiliaCenter for Cooperative Research in Biomaterials (CIC BiomaGUNE)The University of MelbourneUniversidade Estadual Paulista (UNESP)Universidade Estadual de Campinas (UNICAMP)Ganassin, RayaneDa Silva, Victor Carlos MelloAraujo, Victor Hugo SousaTavares, Giulia RosaDa Silva, Patrícia BentoCáceres-Vélez, Paolin RocioPorcel, Joaquin E MartínezRodrigues, Mosar CorrêaAndreozzi, PatriziaFernandes, Richard Perosa [UNESP]Fonseca-Santos, BrunoMoya, SergioAzevedo, Ricardo BentesChorilli, Marlus [UNESP]Muehlmann, Luis Alexandre2022-05-01T13:41:27Z2022-05-01T13:41:27Z2022-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article167-179http://dx.doi.org/10.2217/nnm-2021-0229Nanomedicine, v. 17, n. 3, p. 167-179, 2022.1748-69631743-5889http://hdl.handle.net/11449/23409710.2217/nnm-2021-02292-s2.0-85123968657Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNanomedicineinfo:eu-repo/semantics/openAccess2022-05-01T13:41:27Zoai:repositorio.unesp.br:11449/234097Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-01T13:41:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells |
| title |
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells |
| spellingShingle |
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells Ganassin, Rayane cancer colloid colon adenocarcinoma drug delivery murumuru butter |
| title_short |
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells |
| title_full |
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells |
| title_fullStr |
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells |
| title_full_unstemmed |
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells |
| title_sort |
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells |
| author |
Ganassin, Rayane |
| author_facet |
Ganassin, Rayane Da Silva, Victor Carlos Mello Araujo, Victor Hugo Sousa Tavares, Giulia Rosa Da Silva, Patrícia Bento Cáceres-Vélez, Paolin Rocio Porcel, Joaquin E Martínez Rodrigues, Mosar Corrêa Andreozzi, Patrizia Fernandes, Richard Perosa [UNESP] Fonseca-Santos, Bruno Moya, Sergio Azevedo, Ricardo Bentes Chorilli, Marlus [UNESP] Muehlmann, Luis Alexandre |
| author_role |
author |
| author2 |
Da Silva, Victor Carlos Mello Araujo, Victor Hugo Sousa Tavares, Giulia Rosa Da Silva, Patrícia Bento Cáceres-Vélez, Paolin Rocio Porcel, Joaquin E Martínez Rodrigues, Mosar Corrêa Andreozzi, Patrizia Fernandes, Richard Perosa [UNESP] Fonseca-Santos, Bruno Moya, Sergio Azevedo, Ricardo Bentes Chorilli, Marlus [UNESP] Muehlmann, Luis Alexandre |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
University of Brasilia Center for Cooperative Research in Biomaterials (CIC BiomaGUNE) The University of Melbourne Universidade Estadual Paulista (UNESP) Universidade Estadual de Campinas (UNICAMP) |
| dc.contributor.author.fl_str_mv |
Ganassin, Rayane Da Silva, Victor Carlos Mello Araujo, Victor Hugo Sousa Tavares, Giulia Rosa Da Silva, Patrícia Bento Cáceres-Vélez, Paolin Rocio Porcel, Joaquin E Martínez Rodrigues, Mosar Corrêa Andreozzi, Patrizia Fernandes, Richard Perosa [UNESP] Fonseca-Santos, Bruno Moya, Sergio Azevedo, Ricardo Bentes Chorilli, Marlus [UNESP] Muehlmann, Luis Alexandre |
| dc.subject.por.fl_str_mv |
cancer colloid colon adenocarcinoma drug delivery murumuru butter |
| topic |
cancer colloid colon adenocarcinoma drug delivery murumuru butter |
| description |
Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-05-01T13:41:27Z 2022-05-01T13:41:27Z 2022-02-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2217/nnm-2021-0229 Nanomedicine, v. 17, n. 3, p. 167-179, 2022. 1748-6963 1743-5889 http://hdl.handle.net/11449/234097 10.2217/nnm-2021-0229 2-s2.0-85123968657 |
| url |
http://dx.doi.org/10.2217/nnm-2021-0229 http://hdl.handle.net/11449/234097 |
| identifier_str_mv |
Nanomedicine, v. 17, n. 3, p. 167-179, 2022. 1748-6963 1743-5889 10.2217/nnm-2021-0229 2-s2.0-85123968657 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Nanomedicine |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
167-179 |
| dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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|
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1799965307131920384 |