Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=13&page=493 http://hdl.handle.net/11449/10963 |
Resumo: | Background: Methylprednisolone is one of the most commonly used steroids for management of chronic back pain via epidural injection. Its inadvertent injection into the intrathecal space is associated with complications such as adhesive arachnoiditis.Objective: The present study aimed to assess the clinical and histological changes associated with the injection of methylprednisolone into the intrathecal space of dogs.Study Design: A randomized, double blind, controlled animal trial.Methods: After approval by the animal research ethics committee, 14 dogs were studied in a randomized double blind controlled trial. They were assigned to one of 2 groups: Group I received 1 mL of 0.9% normal saline; Group II received 1 mL (1.15mg/kg) of methylprednisolone into the intrathecal space. Animals were clinically evaluated for 21 days, and then sacrificed. The lumbar and sacral portions of their spinal cords were removed for histological examination.Results: In Group I, there were no clinical or histological changes. All animals in Group II showed no clinical changes but all exhibited histological changes in the spinal cord. The main histological changes consisted of meningeal thickening and lymphocytic infiltrates in the blood vessels. In 3 animals, adhesion of pia, arachnoid, and dura matter was noted and the nerve roots were surrounded by fibrosis. In one animal, necrosis of the spinal cord was evident.Limitations: The limitations of the present study include: small sample of animals (n=14), relative short clinical follow-up (21 days), and use of a commercially available drug solution, which is not preservative free.Conclusion: The present study demonstrated that the intrathecal administration of commercially available methylprednisolone was responsible for causing histological changes in the spinal cord and meninges of the animals studied. |
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Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in DogsMethylprednisoloneintrathecal injectionsteroidsadhesive arachnoiditislow back painepidural injectionspinal cordBackground: Methylprednisolone is one of the most commonly used steroids for management of chronic back pain via epidural injection. Its inadvertent injection into the intrathecal space is associated with complications such as adhesive arachnoiditis.Objective: The present study aimed to assess the clinical and histological changes associated with the injection of methylprednisolone into the intrathecal space of dogs.Study Design: A randomized, double blind, controlled animal trial.Methods: After approval by the animal research ethics committee, 14 dogs were studied in a randomized double blind controlled trial. They were assigned to one of 2 groups: Group I received 1 mL of 0.9% normal saline; Group II received 1 mL (1.15mg/kg) of methylprednisolone into the intrathecal space. Animals were clinically evaluated for 21 days, and then sacrificed. The lumbar and sacral portions of their spinal cords were removed for histological examination.Results: In Group I, there were no clinical or histological changes. All animals in Group II showed no clinical changes but all exhibited histological changes in the spinal cord. The main histological changes consisted of meningeal thickening and lymphocytic infiltrates in the blood vessels. In 3 animals, adhesion of pia, arachnoid, and dura matter was noted and the nerve roots were surrounded by fibrosis. In one animal, necrosis of the spinal cord was evident.Limitations: The limitations of the present study include: small sample of animals (n=14), relative short clinical follow-up (21 days), and use of a commercially available drug solution, which is not preservative free.Conclusion: The present study demonstrated that the intrathecal administration of commercially available methylprednisolone was responsible for causing histological changes in the spinal cord and meninges of the animals studied.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Texas Med Branch Galveston, Dept Anesthesiol, Galveston, TX 77555 USASão Paulo State Univ, Dept Pathol, São Paulo, BrazilSão Paulo State Univ, Dept Anesthesiol, São Paulo, BrazilSão Paulo State Univ, Dept Pathol, São Paulo, BrazilSão Paulo State Univ, Dept Anesthesiol, São Paulo, BrazilAm Soc Interventional Pain PhysiciansUniv Texas Med Branch GalvestonUniversidade Estadual Paulista (Unesp)Lima, Rodrigo MoreiraNavarro, Lais H.Carness, Jeffrey M.Barros, Guilherme A. [UNESP]Marques, Mariângela Esther Alencar [UNESP]Solanki, DaneshvariGanem, Eliana Marisa [UNESP]2014-05-20T13:32:07Z2014-05-20T13:32:07Z2010-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject493-501http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=13&page=493Pain Physician. Paducah: Am Soc Interventional Pain Physicians, v. 13, n. 5, p. 493-501, 2010.1533-3159http://hdl.handle.net/11449/10963WOS:00028286620000882269421307688207528116925519142Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPain Physician2.5560,968info:eu-repo/semantics/openAccess2024-08-14T13:21:24Zoai:repositorio.unesp.br:11449/10963Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T13:21:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs |
title |
Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs |
spellingShingle |
Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs Lima, Rodrigo Moreira Methylprednisolone intrathecal injection steroids adhesive arachnoiditis low back pain epidural injection spinal cord |
title_short |
Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs |
title_full |
Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs |
title_fullStr |
Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs |
title_full_unstemmed |
Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs |
title_sort |
Clinical and Histological Effects of the Intrathecal Administration of Methylprednisolone in Dogs |
author |
Lima, Rodrigo Moreira |
author_facet |
Lima, Rodrigo Moreira Navarro, Lais H. Carness, Jeffrey M. Barros, Guilherme A. [UNESP] Marques, Mariângela Esther Alencar [UNESP] Solanki, Daneshvari Ganem, Eliana Marisa [UNESP] |
author_role |
author |
author2 |
Navarro, Lais H. Carness, Jeffrey M. Barros, Guilherme A. [UNESP] Marques, Mariângela Esther Alencar [UNESP] Solanki, Daneshvari Ganem, Eliana Marisa [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Texas Med Branch Galveston Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Lima, Rodrigo Moreira Navarro, Lais H. Carness, Jeffrey M. Barros, Guilherme A. [UNESP] Marques, Mariângela Esther Alencar [UNESP] Solanki, Daneshvari Ganem, Eliana Marisa [UNESP] |
dc.subject.por.fl_str_mv |
Methylprednisolone intrathecal injection steroids adhesive arachnoiditis low back pain epidural injection spinal cord |
topic |
Methylprednisolone intrathecal injection steroids adhesive arachnoiditis low back pain epidural injection spinal cord |
description |
Background: Methylprednisolone is one of the most commonly used steroids for management of chronic back pain via epidural injection. Its inadvertent injection into the intrathecal space is associated with complications such as adhesive arachnoiditis.Objective: The present study aimed to assess the clinical and histological changes associated with the injection of methylprednisolone into the intrathecal space of dogs.Study Design: A randomized, double blind, controlled animal trial.Methods: After approval by the animal research ethics committee, 14 dogs were studied in a randomized double blind controlled trial. They were assigned to one of 2 groups: Group I received 1 mL of 0.9% normal saline; Group II received 1 mL (1.15mg/kg) of methylprednisolone into the intrathecal space. Animals were clinically evaluated for 21 days, and then sacrificed. The lumbar and sacral portions of their spinal cords were removed for histological examination.Results: In Group I, there were no clinical or histological changes. All animals in Group II showed no clinical changes but all exhibited histological changes in the spinal cord. The main histological changes consisted of meningeal thickening and lymphocytic infiltrates in the blood vessels. In 3 animals, adhesion of pia, arachnoid, and dura matter was noted and the nerve roots were surrounded by fibrosis. In one animal, necrosis of the spinal cord was evident.Limitations: The limitations of the present study include: small sample of animals (n=14), relative short clinical follow-up (21 days), and use of a commercially available drug solution, which is not preservative free.Conclusion: The present study demonstrated that the intrathecal administration of commercially available methylprednisolone was responsible for causing histological changes in the spinal cord and meninges of the animals studied. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-09-01 2014-05-20T13:32:07Z 2014-05-20T13:32:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=13&page=493 Pain Physician. Paducah: Am Soc Interventional Pain Physicians, v. 13, n. 5, p. 493-501, 2010. 1533-3159 http://hdl.handle.net/11449/10963 WOS:000282866200008 8226942130768820 7528116925519142 |
url |
http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=13&page=493 http://hdl.handle.net/11449/10963 |
identifier_str_mv |
Pain Physician. Paducah: Am Soc Interventional Pain Physicians, v. 13, n. 5, p. 493-501, 2010. 1533-3159 WOS:000282866200008 8226942130768820 7528116925519142 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pain Physician 2.556 0,968 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
493-501 |
dc.publisher.none.fl_str_mv |
Am Soc Interventional Pain Physicians |
publisher.none.fl_str_mv |
Am Soc Interventional Pain Physicians |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128148595802112 |