Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jsbmb.2017.10.009 http://hdl.handle.net/11449/175385 |
Resumo: | This study aimed to evaluate the association between pretreatment vitamin D (VD) deficiency with breast cancer prognostic features in Brazilian postmenopausal women. An analytical cross sectional study was conducted with 192 women, aged 45–75 years, attended at University Hospital. Women with recent diagnosis of breast cancer, in amenorrhea >12 months and age ≥45 years, without medication use or clinical conditions that interfere with VD values were included. Clinical and anthropometric data were collected. Serum level of 25 hydroxyvitamin D [25(OH)D] was measured in all patients until 20 days after breast cancer diagnosis, and was classified as normal (≥30 ng/mL), insufficiency (20–29 ng/mL) and deficiency (<20 ng/mL). Data on breast cancer (histopathological type, grade, tumor stage, lymph node status), hormone status (estrogen receptor, ER, progesterone receptor, PR), human epidermal growth factor receptor type 2 (HER2) and epithelial proliferative activity (Ki-67) were collected. For statistical analysis, the t-student test, the Gamma Distribution (asymmetric variables), the chi-square test and the logistic regression (OR-odds ratio) were used. The median 25(OH)D level was 25.8 ng/mL (range 12.0–59.2 ng/mL). Sufficient vitamin D levels were detected in 65 patients (33.9%), whereas insufficient levels in 92 patients (47.9%), and deficient levels in 35 patients (18.2%). Participants with insufficient and deficient 25(OH)D levels had a higher proportion of tumors with a high grade and locally advanced and metastatic disease, more positive lymph node, a lower proportion of ER, PR positives tumors and higher Ki-67(p < 0.05). Patients with normal vitamin D had a higher frequency of luminal A (47.7%) and luminal B (32.2%) tumors when compared to patients with vitamin D insufficiency or deficiency. Furthermore, all cases of triple negative were detected in women with low VD levels. Multivariate analysis, after adjusting for age, time since menopause and BMI, showed that insufficient and deficient level of vitamin D were significantly associated with negative estrogen receptor (OR 3.77 CI 95% 1.76–8.09 and OR 3.99 CI 95% 1.83–8.68), high Ki-67 (OR 2.50, CI 95% 1.35–4.63, and OR 2.62, CI 95% 1.40–4.98), and positive axillary lymph node status (OR 1.59, CI 95% 1.03–2.33, and OR 1.58, CI 95% 1.02–2.92) respectively. In Brazilian postmenopausal women with breast cancer, there was an association between vitamin D insufficiency or deficiency and tumors with worse prognostic features. Low vitamin D levels were shown to be a risk factor for ER negative tumors, with positive axilla and a higher rate of cell proliferation. |
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Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal womenBreast cancerImmunohistochemical profilePostmenopausal womenVitamin DThis study aimed to evaluate the association between pretreatment vitamin D (VD) deficiency with breast cancer prognostic features in Brazilian postmenopausal women. An analytical cross sectional study was conducted with 192 women, aged 45–75 years, attended at University Hospital. Women with recent diagnosis of breast cancer, in amenorrhea >12 months and age ≥45 years, without medication use or clinical conditions that interfere with VD values were included. Clinical and anthropometric data were collected. Serum level of 25 hydroxyvitamin D [25(OH)D] was measured in all patients until 20 days after breast cancer diagnosis, and was classified as normal (≥30 ng/mL), insufficiency (20–29 ng/mL) and deficiency (<20 ng/mL). Data on breast cancer (histopathological type, grade, tumor stage, lymph node status), hormone status (estrogen receptor, ER, progesterone receptor, PR), human epidermal growth factor receptor type 2 (HER2) and epithelial proliferative activity (Ki-67) were collected. For statistical analysis, the t-student test, the Gamma Distribution (asymmetric variables), the chi-square test and the logistic regression (OR-odds ratio) were used. The median 25(OH)D level was 25.8 ng/mL (range 12.0–59.2 ng/mL). Sufficient vitamin D levels were detected in 65 patients (33.9%), whereas insufficient levels in 92 patients (47.9%), and deficient levels in 35 patients (18.2%). Participants with insufficient and deficient 25(OH)D levels had a higher proportion of tumors with a high grade and locally advanced and metastatic disease, more positive lymph node, a lower proportion of ER, PR positives tumors and higher Ki-67(p < 0.05). Patients with normal vitamin D had a higher frequency of luminal A (47.7%) and luminal B (32.2%) tumors when compared to patients with vitamin D insufficiency or deficiency. Furthermore, all cases of triple negative were detected in women with low VD levels. Multivariate analysis, after adjusting for age, time since menopause and BMI, showed that insufficient and deficient level of vitamin D were significantly associated with negative estrogen receptor (OR 3.77 CI 95% 1.76–8.09 and OR 3.99 CI 95% 1.83–8.68), high Ki-67 (OR 2.50, CI 95% 1.35–4.63, and OR 2.62, CI 95% 1.40–4.98), and positive axillary lymph node status (OR 1.59, CI 95% 1.03–2.33, and OR 1.58, CI 95% 1.02–2.92) respectively. In Brazilian postmenopausal women with breast cancer, there was an association between vitamin D insufficiency or deficiency and tumors with worse prognostic features. Low vitamin D levels were shown to be a risk factor for ER negative tumors, with positive axilla and a higher rate of cell proliferation.Department of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University—UNESPDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University—UNESPUniversidade Estadual Paulista (Unesp)de Sousa Almeida-Filho, Benedito [UNESP]De Luca Vespoli, Heloisa [UNESP]Pessoa, Eduardo Carvalho [UNESP]Machado, Murilo [UNESP]Nahas-Neto, Jorge [UNESP]Nahas, Eliana Aguiar Petri [UNESP]2018-12-11T17:15:35Z2018-12-11T17:15:35Z2017-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article284-289application/pdfhttp://dx.doi.org/10.1016/j.jsbmb.2017.10.009Journal of Steroid Biochemistry and Molecular Biology, v. 174, p. 284-289.1879-12200960-0760http://hdl.handle.net/11449/17538510.1016/j.jsbmb.2017.10.0092-s2.0-850322193312-s2.0-85032219331.pdf41551705747884170000-0002-0803-8535Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Steroid Biochemistry and Molecular Biology1,431info:eu-repo/semantics/openAccess2024-08-16T14:07:07Zoai:repositorio.unesp.br:11449/175385Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women |
title |
Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women |
spellingShingle |
Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women de Sousa Almeida-Filho, Benedito [UNESP] Breast cancer Immunohistochemical profile Postmenopausal women Vitamin D |
title_short |
Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women |
title_full |
Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women |
title_fullStr |
Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women |
title_full_unstemmed |
Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women |
title_sort |
Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women |
author |
de Sousa Almeida-Filho, Benedito [UNESP] |
author_facet |
de Sousa Almeida-Filho, Benedito [UNESP] De Luca Vespoli, Heloisa [UNESP] Pessoa, Eduardo Carvalho [UNESP] Machado, Murilo [UNESP] Nahas-Neto, Jorge [UNESP] Nahas, Eliana Aguiar Petri [UNESP] |
author_role |
author |
author2 |
De Luca Vespoli, Heloisa [UNESP] Pessoa, Eduardo Carvalho [UNESP] Machado, Murilo [UNESP] Nahas-Neto, Jorge [UNESP] Nahas, Eliana Aguiar Petri [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Sousa Almeida-Filho, Benedito [UNESP] De Luca Vespoli, Heloisa [UNESP] Pessoa, Eduardo Carvalho [UNESP] Machado, Murilo [UNESP] Nahas-Neto, Jorge [UNESP] Nahas, Eliana Aguiar Petri [UNESP] |
dc.subject.por.fl_str_mv |
Breast cancer Immunohistochemical profile Postmenopausal women Vitamin D |
topic |
Breast cancer Immunohistochemical profile Postmenopausal women Vitamin D |
description |
This study aimed to evaluate the association between pretreatment vitamin D (VD) deficiency with breast cancer prognostic features in Brazilian postmenopausal women. An analytical cross sectional study was conducted with 192 women, aged 45–75 years, attended at University Hospital. Women with recent diagnosis of breast cancer, in amenorrhea >12 months and age ≥45 years, without medication use or clinical conditions that interfere with VD values were included. Clinical and anthropometric data were collected. Serum level of 25 hydroxyvitamin D [25(OH)D] was measured in all patients until 20 days after breast cancer diagnosis, and was classified as normal (≥30 ng/mL), insufficiency (20–29 ng/mL) and deficiency (<20 ng/mL). Data on breast cancer (histopathological type, grade, tumor stage, lymph node status), hormone status (estrogen receptor, ER, progesterone receptor, PR), human epidermal growth factor receptor type 2 (HER2) and epithelial proliferative activity (Ki-67) were collected. For statistical analysis, the t-student test, the Gamma Distribution (asymmetric variables), the chi-square test and the logistic regression (OR-odds ratio) were used. The median 25(OH)D level was 25.8 ng/mL (range 12.0–59.2 ng/mL). Sufficient vitamin D levels were detected in 65 patients (33.9%), whereas insufficient levels in 92 patients (47.9%), and deficient levels in 35 patients (18.2%). Participants with insufficient and deficient 25(OH)D levels had a higher proportion of tumors with a high grade and locally advanced and metastatic disease, more positive lymph node, a lower proportion of ER, PR positives tumors and higher Ki-67(p < 0.05). Patients with normal vitamin D had a higher frequency of luminal A (47.7%) and luminal B (32.2%) tumors when compared to patients with vitamin D insufficiency or deficiency. Furthermore, all cases of triple negative were detected in women with low VD levels. Multivariate analysis, after adjusting for age, time since menopause and BMI, showed that insufficient and deficient level of vitamin D were significantly associated with negative estrogen receptor (OR 3.77 CI 95% 1.76–8.09 and OR 3.99 CI 95% 1.83–8.68), high Ki-67 (OR 2.50, CI 95% 1.35–4.63, and OR 2.62, CI 95% 1.40–4.98), and positive axillary lymph node status (OR 1.59, CI 95% 1.03–2.33, and OR 1.58, CI 95% 1.02–2.92) respectively. In Brazilian postmenopausal women with breast cancer, there was an association between vitamin D insufficiency or deficiency and tumors with worse prognostic features. Low vitamin D levels were shown to be a risk factor for ER negative tumors, with positive axilla and a higher rate of cell proliferation. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-01 2018-12-11T17:15:35Z 2018-12-11T17:15:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jsbmb.2017.10.009 Journal of Steroid Biochemistry and Molecular Biology, v. 174, p. 284-289. 1879-1220 0960-0760 http://hdl.handle.net/11449/175385 10.1016/j.jsbmb.2017.10.009 2-s2.0-85032219331 2-s2.0-85032219331.pdf 4155170574788417 0000-0002-0803-8535 |
url |
http://dx.doi.org/10.1016/j.jsbmb.2017.10.009 http://hdl.handle.net/11449/175385 |
identifier_str_mv |
Journal of Steroid Biochemistry and Molecular Biology, v. 174, p. 284-289. 1879-1220 0960-0760 10.1016/j.jsbmb.2017.10.009 2-s2.0-85032219331 2-s2.0-85032219331.pdf 4155170574788417 0000-0002-0803-8535 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Steroid Biochemistry and Molecular Biology 1,431 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
284-289 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128148648230912 |