PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11046-019-00355-6 http://hdl.handle.net/11449/189394 |
Resumo: | Inteins (internal proteins) are mobile genetic elements, inserted in housekeeping proteins, with self-splicing properties. Some of these elements have been recently pointed out as modulators of genetic expression or protein function. Herein, we evaluated, in silico, the distribution and phylogenetic patterns of PRP8 intein among 93 fungal strains of the order Onygenales. PRP8 intein(s) are present in most of the species (45/49), mainly as full-length inteins (containing both the Splicing and the Homing Endonuclease domains), and must have transferred vertically in all lineages, since their phylogeny reflects the group phylogeny. While the distribution of PRP8 intein(s) varies among species of Onygenaceae family, being absent in Coccidioides spp. and present as full and mini-intein in other species, they are consistently observed as full-length inteins in all evaluated pathogenic species of the Arthrodermataceae and Ajellomycetaceae families. This conservative and massive PRP8 intein presence in Ajellomycetacean and Arthrodermatecean species reinforces the previous idea that such genetic elements do not decrease the fungal fitness significantly and even might play some role in the host–pathogen relationship, at least in these two fungal groups. We may better position the species Ophidiomyces ophiodiicola (with no intein) in the Onygenaceae family and Onygena corvina (with a full-length intein) as a basal member in the Arthrodermataceae family. |
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PRP8 Intein in Onygenales: Distribution and Phylogenetic AspectsEvolutionOnygenalesPhylogenyPRP8 inteinInteins (internal proteins) are mobile genetic elements, inserted in housekeeping proteins, with self-splicing properties. Some of these elements have been recently pointed out as modulators of genetic expression or protein function. Herein, we evaluated, in silico, the distribution and phylogenetic patterns of PRP8 intein among 93 fungal strains of the order Onygenales. PRP8 intein(s) are present in most of the species (45/49), mainly as full-length inteins (containing both the Splicing and the Homing Endonuclease domains), and must have transferred vertically in all lineages, since their phylogeny reflects the group phylogeny. While the distribution of PRP8 intein(s) varies among species of Onygenaceae family, being absent in Coccidioides spp. and present as full and mini-intein in other species, they are consistently observed as full-length inteins in all evaluated pathogenic species of the Arthrodermataceae and Ajellomycetaceae families. This conservative and massive PRP8 intein presence in Ajellomycetacean and Arthrodermatecean species reinforces the previous idea that such genetic elements do not decrease the fungal fitness significantly and even might play some role in the host–pathogen relationship, at least in these two fungal groups. We may better position the species Ophidiomyces ophiodiicola (with no intein) in the Onygenaceae family and Onygena corvina (with a full-length intein) as a basal member in the Arthrodermataceae family.Microbiology and Immunology Department Biosciences Institute of Botucatu State University of Sao Paulo (UNESP)Tropical Medicine Institute of Rio Grande do Norte Federal University of Rio Grande do NorteMicrobiology and Immunology Department Biosciences Institute of Botucatu State University of Sao Paulo (UNESP)Universidade Estadual Paulista (Unesp)Federal University of Rio Grande do NorteGarcia Garces, Hans [UNESP]Hamae Yamauchi, Danielle [UNESP]Theodoro, Raquel CordeiroBagagli, Eduardo [UNESP]2019-10-06T16:39:16Z2019-10-06T16:39:16Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s11046-019-00355-6Mycopathologia.1573-08320301-486Xhttp://hdl.handle.net/11449/18939410.1007/s11046-019-00355-62-s2.0-8506884321033203275704295390000-0002-8003-4109Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMycopathologiainfo:eu-repo/semantics/openAccess2021-10-23T10:11:29Zoai:repositorio.unesp.br:11449/189394Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:56:23.652934Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects |
title |
PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects |
spellingShingle |
PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects Garcia Garces, Hans [UNESP] Evolution Onygenales Phylogeny PRP8 intein |
title_short |
PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects |
title_full |
PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects |
title_fullStr |
PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects |
title_full_unstemmed |
PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects |
title_sort |
PRP8 Intein in Onygenales: Distribution and Phylogenetic Aspects |
author |
Garcia Garces, Hans [UNESP] |
author_facet |
Garcia Garces, Hans [UNESP] Hamae Yamauchi, Danielle [UNESP] Theodoro, Raquel Cordeiro Bagagli, Eduardo [UNESP] |
author_role |
author |
author2 |
Hamae Yamauchi, Danielle [UNESP] Theodoro, Raquel Cordeiro Bagagli, Eduardo [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Federal University of Rio Grande do Norte |
dc.contributor.author.fl_str_mv |
Garcia Garces, Hans [UNESP] Hamae Yamauchi, Danielle [UNESP] Theodoro, Raquel Cordeiro Bagagli, Eduardo [UNESP] |
dc.subject.por.fl_str_mv |
Evolution Onygenales Phylogeny PRP8 intein |
topic |
Evolution Onygenales Phylogeny PRP8 intein |
description |
Inteins (internal proteins) are mobile genetic elements, inserted in housekeeping proteins, with self-splicing properties. Some of these elements have been recently pointed out as modulators of genetic expression or protein function. Herein, we evaluated, in silico, the distribution and phylogenetic patterns of PRP8 intein among 93 fungal strains of the order Onygenales. PRP8 intein(s) are present in most of the species (45/49), mainly as full-length inteins (containing both the Splicing and the Homing Endonuclease domains), and must have transferred vertically in all lineages, since their phylogeny reflects the group phylogeny. While the distribution of PRP8 intein(s) varies among species of Onygenaceae family, being absent in Coccidioides spp. and present as full and mini-intein in other species, they are consistently observed as full-length inteins in all evaluated pathogenic species of the Arthrodermataceae and Ajellomycetaceae families. This conservative and massive PRP8 intein presence in Ajellomycetacean and Arthrodermatecean species reinforces the previous idea that such genetic elements do not decrease the fungal fitness significantly and even might play some role in the host–pathogen relationship, at least in these two fungal groups. We may better position the species Ophidiomyces ophiodiicola (with no intein) in the Onygenaceae family and Onygena corvina (with a full-length intein) as a basal member in the Arthrodermataceae family. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:39:16Z 2019-10-06T16:39:16Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11046-019-00355-6 Mycopathologia. 1573-0832 0301-486X http://hdl.handle.net/11449/189394 10.1007/s11046-019-00355-6 2-s2.0-85068843210 3320327570429539 0000-0002-8003-4109 |
url |
http://dx.doi.org/10.1007/s11046-019-00355-6 http://hdl.handle.net/11449/189394 |
identifier_str_mv |
Mycopathologia. 1573-0832 0301-486X 10.1007/s11046-019-00355-6 2-s2.0-85068843210 3320327570429539 0000-0002-8003-4109 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mycopathologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129476454776832 |