Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet

Detalhes bibliográficos
Autor(a) principal: Minuzzi, Luciele Guerra
Data de Publicação: 2020
Outros Autores: Kuga, Gabriel Keine [UNESP], Breda, Leonardo, Gaspar, Rafael Calais, Muñoz, Vitor Rosetto, Pereira, Rodrigo Martins, Botezelli, José Diego, Da Silva, Adelino S. R., Cintra, Dennys Esper, De Moura, Leandro Pereira, Ropelle, Eduardo Rochete, Pauli, José Rodrigo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1055/a-0885-9872
http://hdl.handle.net/11449/198381
Resumo: Background APPL1, an adapter protein, interact directly with adiponectin receptors mediating adiponectin signaling and acting as a critical regulator of the crosstalk between adiponectin and insulin signaling pathway. The inadequate level of physical activity, high-calorie intake, or both lead to adverse consequences on health, like insulin resistance. On the order hand, physical exercise acts positively in the insulin action. Purpose Here, we investigated the effects of short-term resistance training (RT) on APPL1 content and adiponectin pathway in the liver of mice fed a long-term high-fat diet. Methods Swiss mice were distributed into 3 groups: Mice that fed a chow diet (CTR); Mice fed a high-fat diet for 16 months (HFD); and mice fed a high-fat diet for 16 months and submitted to a climbing ladder exercise (RT) for 7 days (HFD-EXE). Results The results show that short-term RT increases the APPL1 content but wasn't able to alter AdipoR1 and AdipoR2 content in the liver of HFD-EXE mice. However, this increase in the APPL1 content in response to RT was accompanied by improvement in the insulin sensitivity. Conclusion In summary, our data suggested that short-term RT improves glycemic homeostasis and increases APPL1 in the hepatic tissue of mice treated with long-term high-fat diet.
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spelling Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat DietadiponectinAPPL1hepatic tissueobesity, elderlyresistance trainingBackground APPL1, an adapter protein, interact directly with adiponectin receptors mediating adiponectin signaling and acting as a critical regulator of the crosstalk between adiponectin and insulin signaling pathway. The inadequate level of physical activity, high-calorie intake, or both lead to adverse consequences on health, like insulin resistance. On the order hand, physical exercise acts positively in the insulin action. Purpose Here, we investigated the effects of short-term resistance training (RT) on APPL1 content and adiponectin pathway in the liver of mice fed a long-term high-fat diet. Methods Swiss mice were distributed into 3 groups: Mice that fed a chow diet (CTR); Mice fed a high-fat diet for 16 months (HFD); and mice fed a high-fat diet for 16 months and submitted to a climbing ladder exercise (RT) for 7 days (HFD-EXE). Results The results show that short-term RT increases the APPL1 content but wasn't able to alter AdipoR1 and AdipoR2 content in the liver of HFD-EXE mice. However, this increase in the APPL1 content in response to RT was accompanied by improvement in the insulin sensitivity. Conclusion In summary, our data suggested that short-term RT improves glycemic homeostasis and increases APPL1 in the hepatic tissue of mice treated with long-term high-fat diet.Laboratory of Molecular Biology of Exercise (LaBMEx) University of Campinas (UNICAMP), 1300 Pedro Zaccaria st., Jd. Sta. LuziaPost-graduate Program in Movement Sciences São Paulo State University (UNESP)Laboratory of Nutritional Genomics (LabGeN) University of Campinas (UNICAMP)Post-graduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School USPLaboratory of Cell Signaling Obesity and Comorbidities Research Center (OCRC) University of CampinasCEPECE - Center of Research in Sport Sciences School of Applied Sciences University of Campinas (UNICAMP)Post-graduate Program in Movement Sciences São Paulo State University (UNESP)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Minuzzi, Luciele GuerraKuga, Gabriel Keine [UNESP]Breda, LeonardoGaspar, Rafael CalaisMuñoz, Vitor RosettoPereira, Rodrigo MartinsBotezelli, José DiegoDa Silva, Adelino S. R.Cintra, Dennys EsperDe Moura, Leandro PereiraRopelle, Eduardo RochetePauli, José Rodrigo2020-12-12T01:11:19Z2020-12-12T01:11:19Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article30-37http://dx.doi.org/10.1055/a-0885-9872Experimental and Clinical Endocrinology and Diabetes, v. 128, n. 1, p. 30-37, 2020.1439-36460947-7349http://hdl.handle.net/11449/19838110.1055/a-0885-98722-s2.0-85077664884Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental and Clinical Endocrinology and Diabetesinfo:eu-repo/semantics/openAccess2021-10-23T10:31:31Zoai:repositorio.unesp.br:11449/198381Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:24:09.276609Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
title Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
spellingShingle Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
Minuzzi, Luciele Guerra
adiponectin
APPL1
hepatic tissue
obesity, elderly
resistance training
title_short Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
title_full Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
title_fullStr Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
title_full_unstemmed Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
title_sort Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
author Minuzzi, Luciele Guerra
author_facet Minuzzi, Luciele Guerra
Kuga, Gabriel Keine [UNESP]
Breda, Leonardo
Gaspar, Rafael Calais
Muñoz, Vitor Rosetto
Pereira, Rodrigo Martins
Botezelli, José Diego
Da Silva, Adelino S. R.
Cintra, Dennys Esper
De Moura, Leandro Pereira
Ropelle, Eduardo Rochete
Pauli, José Rodrigo
author_role author
author2 Kuga, Gabriel Keine [UNESP]
Breda, Leonardo
Gaspar, Rafael Calais
Muñoz, Vitor Rosetto
Pereira, Rodrigo Martins
Botezelli, José Diego
Da Silva, Adelino S. R.
Cintra, Dennys Esper
De Moura, Leandro Pereira
Ropelle, Eduardo Rochete
Pauli, José Rodrigo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Minuzzi, Luciele Guerra
Kuga, Gabriel Keine [UNESP]
Breda, Leonardo
Gaspar, Rafael Calais
Muñoz, Vitor Rosetto
Pereira, Rodrigo Martins
Botezelli, José Diego
Da Silva, Adelino S. R.
Cintra, Dennys Esper
De Moura, Leandro Pereira
Ropelle, Eduardo Rochete
Pauli, José Rodrigo
dc.subject.por.fl_str_mv adiponectin
APPL1
hepatic tissue
obesity, elderly
resistance training
topic adiponectin
APPL1
hepatic tissue
obesity, elderly
resistance training
description Background APPL1, an adapter protein, interact directly with adiponectin receptors mediating adiponectin signaling and acting as a critical regulator of the crosstalk between adiponectin and insulin signaling pathway. The inadequate level of physical activity, high-calorie intake, or both lead to adverse consequences on health, like insulin resistance. On the order hand, physical exercise acts positively in the insulin action. Purpose Here, we investigated the effects of short-term resistance training (RT) on APPL1 content and adiponectin pathway in the liver of mice fed a long-term high-fat diet. Methods Swiss mice were distributed into 3 groups: Mice that fed a chow diet (CTR); Mice fed a high-fat diet for 16 months (HFD); and mice fed a high-fat diet for 16 months and submitted to a climbing ladder exercise (RT) for 7 days (HFD-EXE). Results The results show that short-term RT increases the APPL1 content but wasn't able to alter AdipoR1 and AdipoR2 content in the liver of HFD-EXE mice. However, this increase in the APPL1 content in response to RT was accompanied by improvement in the insulin sensitivity. Conclusion In summary, our data suggested that short-term RT improves glycemic homeostasis and increases APPL1 in the hepatic tissue of mice treated with long-term high-fat diet.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T01:11:19Z
2020-12-12T01:11:19Z
2020-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1055/a-0885-9872
Experimental and Clinical Endocrinology and Diabetes, v. 128, n. 1, p. 30-37, 2020.
1439-3646
0947-7349
http://hdl.handle.net/11449/198381
10.1055/a-0885-9872
2-s2.0-85077664884
url http://dx.doi.org/10.1055/a-0885-9872
http://hdl.handle.net/11449/198381
identifier_str_mv Experimental and Clinical Endocrinology and Diabetes, v. 128, n. 1, p. 30-37, 2020.
1439-3646
0947-7349
10.1055/a-0885-9872
2-s2.0-85077664884
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Experimental and Clinical Endocrinology and Diabetes
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 30-37
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128509538729984