Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0036-46652015000300012 http://hdl.handle.net/11449/140873 |
Resumo: | Nocardia is a ubiquitous microorganism related to pyogranulomatous infection, which is difficult to treat in humans and animals. The occurrence of the disease is on the rise in many countries due to an increase in immunosuppressive diseases and treatments. This report of cases from Brazil presents the genotypic characterization and the antimicrobial susceptibility pattern using the disk-diffusion method and inhibitory minimal concentration with E-test® strips. In summary, this report focuses on infections in young adult men, of which three cases were cutaneous, two pulmonary, one neurological and one systemic. The pulmonary, neurological and systemic cases were attributed to immunosuppressive diseases or treatments. Sequencing analysis of the 16S rRNA segments (1491 bp) identified four isolates of Nocardia farcinica, two isolates of Nocardia nova and one isolate of Nocardia asiatica. N. farcinica was involved in two cutaneous, one systemic and other pulmonary cases; N. nova was involved in one neurological and one pulmonary case; and Nocardia asiatica in one cutaneous case. The disk-diffusion antimicrobial susceptibility test showed that the most effective antimicrobials were amikacin (100%), amoxicillin/clavulanate (100%), cephalexin (100%) and ceftiofur (100%), while isolates had presented most resistance to gentamicin (43%), sulfamethoxazole/trimethoprim (43%) and ampicillin (29%). However, on the inhibitory minimal concentration test (MIC test), only one of the four isolates of Nocardia farcinica was resistant to sulfamethoxazole/trimethoprim. |
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Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in BrazilIdentificação molecular e perfil de sensibilidade a antimicrobianos de sete isolados clínicos de Nocardia spp. no BrasilNocardiosisNocardiaOpportunistic diseaseAntimicrobial susceptibility testNocardia is a ubiquitous microorganism related to pyogranulomatous infection, which is difficult to treat in humans and animals. The occurrence of the disease is on the rise in many countries due to an increase in immunosuppressive diseases and treatments. This report of cases from Brazil presents the genotypic characterization and the antimicrobial susceptibility pattern using the disk-diffusion method and inhibitory minimal concentration with E-test® strips. In summary, this report focuses on infections in young adult men, of which three cases were cutaneous, two pulmonary, one neurological and one systemic. The pulmonary, neurological and systemic cases were attributed to immunosuppressive diseases or treatments. Sequencing analysis of the 16S rRNA segments (1491 bp) identified four isolates of Nocardia farcinica, two isolates of Nocardia nova and one isolate of Nocardia asiatica. N. farcinica was involved in two cutaneous, one systemic and other pulmonary cases; N. nova was involved in one neurological and one pulmonary case; and Nocardia asiatica in one cutaneous case. The disk-diffusion antimicrobial susceptibility test showed that the most effective antimicrobials were amikacin (100%), amoxicillin/clavulanate (100%), cephalexin (100%) and ceftiofur (100%), while isolates had presented most resistance to gentamicin (43%), sulfamethoxazole/trimethoprim (43%) and ampicillin (29%). However, on the inhibitory minimal concentration test (MIC test), only one of the four isolates of Nocardia farcinica was resistant to sulfamethoxazole/trimethoprim.Nocardia é um microorganismo ubiquitário relacionado a infecções piogranulomatosas, com difícil resolução tecidual em humanos e animais. A doença é mundialmente emergente devido ao aumento de doenças e tratamentos imunossupressores. Este relato de casos ocorridos no Brasil visa apresentar a identificação molecular dos isolados e o padrão de sensibilidade a antimicrobianos por disco-difusão e concentração inibitória mínima (CIM) através de fitas E-test®. Os casos ocorreram em homens, em idade adulta. Três quadros foram cutâneos, dois pulmonares, um neurológico e um sistêmico. O quadro respiratório, o neurológico e um sistêmico estavam associados à doença ou terapia imunossupressoras. O sequenciamento do gene 16S rRNA (1491pb) possibilitou a identificação de quatro isolados de Nocardia farcinica, dois de Nocardia nova e um de Nocardia asiatica. N. farcinica foi observada em dois casos dermatológicos, um pulmonar e um quadro sistêmico, N. nova foi isolada de um caso neurológico e outro pulmonar; e N. asiatica em um caso dermatológico. O teste de disco-difusão mostrou que amicacina (100%), amoxicilina/clavulanato (100%), cefalexina (100%) e ceftiofur (100%) foram mais efetivos; enquanto gentamicina (43%), sulfametoxazol/trimetoprim (43%) e ampicilina (29%) foram menos efetivos. No entanto, no teste de concentração inibitória mínima (CIM), apenas um dos quatro isolados da espécie Nocardia farcinica mostrou-se resistente a sulfametoxazole-trimetropina.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de Santa Maria, Departamento de Medicina Veterinária PreventivaUniversidade Federal de São Paulo, Departamento de Ciências BiológicasUniversidade Estadual Paulista, Departamento de Higiene Veterinária e Saúde Pública, Faculdade de Medicina Veterinária e Zootecnia de BotucatuFAPESP: 2009/56037-1FAPESP: 2010/53494-5Universidade Estadual Paulista (Unesp)Universidade Federal do Paraná (UFPR)Universidade Federal de Santa Maria (UFSM)Chiba UniversityUniversidade Federal de São Paulo (UNIFESP)Condas, Larissa Anuska Zeni [UNESP]Ribeiro, Marcio Garcia [UNESP]Muro, Marisol DominguesVargas, Agueda Castagna deMatsuzawa, TetsuhiroYazawa, KatsukiyoSiqueira, Amanda Keller [UNESP]Salerno, Tatiana [UNESP]Lara, Gustavo Henrique Batista [UNESP]Risseti, Rafaela Mastrangelo [UNESP]Ferreira, Karen SpadariGonoi, Tohru2016-07-07T12:35:48Z2016-07-07T12:35:48Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article251-256application/pdfhttp://dx.doi.org/10.1590/S0036-46652015000300012Revista do Instituto de Medicina Tropical de São Paulo, v. 57, n. 3, p. 251-256, 2015.0036-4665http://hdl.handle.net/11449/14087310.1590/S0036-46652015000300012S0036-46652015000300251S0036-46652015000300251.pdf2209124317273797533184815993552929642034476395020760064395929594Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista do Instituto de Medicina Tropical de São Paulo1.4890,669info:eu-repo/semantics/openAccess2023-10-13T06:06:37Zoai:repositorio.unesp.br:11449/140873Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-13T06:06:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil Identificação molecular e perfil de sensibilidade a antimicrobianos de sete isolados clínicos de Nocardia spp. no Brasil |
title |
Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil |
spellingShingle |
Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil Condas, Larissa Anuska Zeni [UNESP] Nocardiosis Nocardia Opportunistic disease Antimicrobial susceptibility test |
title_short |
Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil |
title_full |
Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil |
title_fullStr |
Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil |
title_full_unstemmed |
Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil |
title_sort |
Molecular identification and antimicrobial resistance pattern of seven clincal isolates of Nocardia spp. in Brazil |
author |
Condas, Larissa Anuska Zeni [UNESP] |
author_facet |
Condas, Larissa Anuska Zeni [UNESP] Ribeiro, Marcio Garcia [UNESP] Muro, Marisol Domingues Vargas, Agueda Castagna de Matsuzawa, Tetsuhiro Yazawa, Katsukiyo Siqueira, Amanda Keller [UNESP] Salerno, Tatiana [UNESP] Lara, Gustavo Henrique Batista [UNESP] Risseti, Rafaela Mastrangelo [UNESP] Ferreira, Karen Spadari Gonoi, Tohru |
author_role |
author |
author2 |
Ribeiro, Marcio Garcia [UNESP] Muro, Marisol Domingues Vargas, Agueda Castagna de Matsuzawa, Tetsuhiro Yazawa, Katsukiyo Siqueira, Amanda Keller [UNESP] Salerno, Tatiana [UNESP] Lara, Gustavo Henrique Batista [UNESP] Risseti, Rafaela Mastrangelo [UNESP] Ferreira, Karen Spadari Gonoi, Tohru |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal do Paraná (UFPR) Universidade Federal de Santa Maria (UFSM) Chiba University Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Condas, Larissa Anuska Zeni [UNESP] Ribeiro, Marcio Garcia [UNESP] Muro, Marisol Domingues Vargas, Agueda Castagna de Matsuzawa, Tetsuhiro Yazawa, Katsukiyo Siqueira, Amanda Keller [UNESP] Salerno, Tatiana [UNESP] Lara, Gustavo Henrique Batista [UNESP] Risseti, Rafaela Mastrangelo [UNESP] Ferreira, Karen Spadari Gonoi, Tohru |
dc.subject.por.fl_str_mv |
Nocardiosis Nocardia Opportunistic disease Antimicrobial susceptibility test |
topic |
Nocardiosis Nocardia Opportunistic disease Antimicrobial susceptibility test |
description |
Nocardia is a ubiquitous microorganism related to pyogranulomatous infection, which is difficult to treat in humans and animals. The occurrence of the disease is on the rise in many countries due to an increase in immunosuppressive diseases and treatments. This report of cases from Brazil presents the genotypic characterization and the antimicrobial susceptibility pattern using the disk-diffusion method and inhibitory minimal concentration with E-test® strips. In summary, this report focuses on infections in young adult men, of which three cases were cutaneous, two pulmonary, one neurological and one systemic. The pulmonary, neurological and systemic cases were attributed to immunosuppressive diseases or treatments. Sequencing analysis of the 16S rRNA segments (1491 bp) identified four isolates of Nocardia farcinica, two isolates of Nocardia nova and one isolate of Nocardia asiatica. N. farcinica was involved in two cutaneous, one systemic and other pulmonary cases; N. nova was involved in one neurological and one pulmonary case; and Nocardia asiatica in one cutaneous case. The disk-diffusion antimicrobial susceptibility test showed that the most effective antimicrobials were amikacin (100%), amoxicillin/clavulanate (100%), cephalexin (100%) and ceftiofur (100%), while isolates had presented most resistance to gentamicin (43%), sulfamethoxazole/trimethoprim (43%) and ampicillin (29%). However, on the inhibitory minimal concentration test (MIC test), only one of the four isolates of Nocardia farcinica was resistant to sulfamethoxazole/trimethoprim. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2016-07-07T12:35:48Z 2016-07-07T12:35:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0036-46652015000300012 Revista do Instituto de Medicina Tropical de São Paulo, v. 57, n. 3, p. 251-256, 2015. 0036-4665 http://hdl.handle.net/11449/140873 10.1590/S0036-46652015000300012 S0036-46652015000300251 S0036-46652015000300251.pdf 2209124317273797 5331848159935529 2964203447639502 0760064395929594 |
url |
http://dx.doi.org/10.1590/S0036-46652015000300012 http://hdl.handle.net/11449/140873 |
identifier_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo, v. 57, n. 3, p. 251-256, 2015. 0036-4665 10.1590/S0036-46652015000300012 S0036-46652015000300251 S0036-46652015000300251.pdf 2209124317273797 5331848159935529 2964203447639502 0760064395929594 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo 1.489 0,669 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
251-256 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964544854917120 |