1.39 - Intestinal Dysbiosis in Autoimmune Diseases
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Tipo de documento: | Capítulo de livro |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3 http://hdl.handle.net/11449/247117 |
Resumo: | Evidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases. |
id |
UNSP_ed8a881dcd003acc3d87e3fc30417e55 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/247117 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
1.39 - Intestinal Dysbiosis in Autoimmune DiseasesAutoimmunityDysbiosisGraves' diseaseHashimoto thyroiditisInflammationMicrobiotaProbioticsRheumatoid arthritisSjögren syndromeSystemic lupus erythematosusSystemic sclerosisType 1 diabetesEvidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases.Microbiology Program Institute of Biosciences Humanities and Exact Sciences, Sao PauloDepartment of Food Engineering and Technology São Paulo State University (UNESP), Sao PauloDepartment of Food Engineering and Technology São Paulo State University (UNESP), Sao PauloHumanities and Exact SciencesUniversidade Estadual Paulista (UNESP)de Oliveira, Gislane Lelis Vilela [UNESP]2023-07-29T13:06:43Z2023-07-29T13:06:43Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart545-563http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3Comprehensive Gut Microbiota, v. 1, p. 545-563.http://hdl.handle.net/11449/24711710.1016/B978-0-12-819265-8.00038-32-s2.0-85151697775Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengComprehensive Gut Microbiotainfo:eu-repo/semantics/openAccess2023-07-29T13:06:43Zoai:repositorio.unesp.br:11449/247117Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:06:34.103238Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
1.39 - Intestinal Dysbiosis in Autoimmune Diseases |
title |
1.39 - Intestinal Dysbiosis in Autoimmune Diseases |
spellingShingle |
1.39 - Intestinal Dysbiosis in Autoimmune Diseases de Oliveira, Gislane Lelis Vilela [UNESP] Autoimmunity Dysbiosis Graves' disease Hashimoto thyroiditis Inflammation Microbiota Probiotics Rheumatoid arthritis Sjögren syndrome Systemic lupus erythematosus Systemic sclerosis Type 1 diabetes |
title_short |
1.39 - Intestinal Dysbiosis in Autoimmune Diseases |
title_full |
1.39 - Intestinal Dysbiosis in Autoimmune Diseases |
title_fullStr |
1.39 - Intestinal Dysbiosis in Autoimmune Diseases |
title_full_unstemmed |
1.39 - Intestinal Dysbiosis in Autoimmune Diseases |
title_sort |
1.39 - Intestinal Dysbiosis in Autoimmune Diseases |
author |
de Oliveira, Gislane Lelis Vilela [UNESP] |
author_facet |
de Oliveira, Gislane Lelis Vilela [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Humanities and Exact Sciences Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
de Oliveira, Gislane Lelis Vilela [UNESP] |
dc.subject.por.fl_str_mv |
Autoimmunity Dysbiosis Graves' disease Hashimoto thyroiditis Inflammation Microbiota Probiotics Rheumatoid arthritis Sjögren syndrome Systemic lupus erythematosus Systemic sclerosis Type 1 diabetes |
topic |
Autoimmunity Dysbiosis Graves' disease Hashimoto thyroiditis Inflammation Microbiota Probiotics Rheumatoid arthritis Sjögren syndrome Systemic lupus erythematosus Systemic sclerosis Type 1 diabetes |
description |
Evidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T13:06:43Z 2023-07-29T13:06:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bookPart |
format |
bookPart |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3 Comprehensive Gut Microbiota, v. 1, p. 545-563. http://hdl.handle.net/11449/247117 10.1016/B978-0-12-819265-8.00038-3 2-s2.0-85151697775 |
url |
http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3 http://hdl.handle.net/11449/247117 |
identifier_str_mv |
Comprehensive Gut Microbiota, v. 1, p. 545-563. 10.1016/B978-0-12-819265-8.00038-3 2-s2.0-85151697775 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Comprehensive Gut Microbiota |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
545-563 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129020759375872 |