1.39 - Intestinal Dysbiosis in Autoimmune Diseases

Detalhes bibliográficos
Autor(a) principal: de Oliveira, Gislane Lelis Vilela [UNESP]
Data de Publicação: 2022
Tipo de documento: Capítulo de livro
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3
http://hdl.handle.net/11449/247117
Resumo: Evidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases.
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spelling 1.39 - Intestinal Dysbiosis in Autoimmune DiseasesAutoimmunityDysbiosisGraves' diseaseHashimoto thyroiditisInflammationMicrobiotaProbioticsRheumatoid arthritisSjögren syndromeSystemic lupus erythematosusSystemic sclerosisType 1 diabetesEvidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases.Microbiology Program Institute of Biosciences Humanities and Exact Sciences, Sao PauloDepartment of Food Engineering and Technology São Paulo State University (UNESP), Sao PauloDepartment of Food Engineering and Technology São Paulo State University (UNESP), Sao PauloHumanities and Exact SciencesUniversidade Estadual Paulista (UNESP)de Oliveira, Gislane Lelis Vilela [UNESP]2023-07-29T13:06:43Z2023-07-29T13:06:43Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart545-563http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3Comprehensive Gut Microbiota, v. 1, p. 545-563.http://hdl.handle.net/11449/24711710.1016/B978-0-12-819265-8.00038-32-s2.0-85151697775Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengComprehensive Gut Microbiotainfo:eu-repo/semantics/openAccess2023-07-29T13:06:43Zoai:repositorio.unesp.br:11449/247117Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:06:34.103238Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
title 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
spellingShingle 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
de Oliveira, Gislane Lelis Vilela [UNESP]
Autoimmunity
Dysbiosis
Graves' disease
Hashimoto thyroiditis
Inflammation
Microbiota
Probiotics
Rheumatoid arthritis
Sjögren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Type 1 diabetes
title_short 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
title_full 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
title_fullStr 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
title_full_unstemmed 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
title_sort 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
author de Oliveira, Gislane Lelis Vilela [UNESP]
author_facet de Oliveira, Gislane Lelis Vilela [UNESP]
author_role author
dc.contributor.none.fl_str_mv Humanities and Exact Sciences
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv de Oliveira, Gislane Lelis Vilela [UNESP]
dc.subject.por.fl_str_mv Autoimmunity
Dysbiosis
Graves' disease
Hashimoto thyroiditis
Inflammation
Microbiota
Probiotics
Rheumatoid arthritis
Sjögren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Type 1 diabetes
topic Autoimmunity
Dysbiosis
Graves' disease
Hashimoto thyroiditis
Inflammation
Microbiota
Probiotics
Rheumatoid arthritis
Sjögren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Type 1 diabetes
description Evidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-07-29T13:06:43Z
2023-07-29T13:06:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3
Comprehensive Gut Microbiota, v. 1, p. 545-563.
http://hdl.handle.net/11449/247117
10.1016/B978-0-12-819265-8.00038-3
2-s2.0-85151697775
url http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3
http://hdl.handle.net/11449/247117
identifier_str_mv Comprehensive Gut Microbiota, v. 1, p. 545-563.
10.1016/B978-0-12-819265-8.00038-3
2-s2.0-85151697775
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Comprehensive Gut Microbiota
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 545-563
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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