The gut microbiome in autoimmune diseases

Detalhes bibliográficos
Autor(a) principal: de Oliveira, Gislane Lellis Vilela [UNESP]
Data de Publicação: 2019
Tipo de documento: Capítulo de livro
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/B978-0-12-815249-2.00033-6
http://hdl.handle.net/11449/200208
Resumo: Dysbiosis observed in autoimmune diseases is associated with decreased bacteria function and diversity, impaired epithelial barrier, bacterial translocation, inflammation, and decreased regulatory T cells (Tregs) in the gut mucosa. The hypotheses proposed to link dysbiosis with autoimmune diseases include molecular mimicry, bystander T cell activation, perpetuation of autoimmunity by inflammatory milieu, T helper 17/Tregs imbalance, and the posttranslational modification of luminal proteins (PTMP) induced by enzymes from dysbiotic microbiota, which modify substrates in a different way than under eubiotic conditions. The defective PTMP might generate neoepitopes that become immunogenic and induce systemic autoimmunity and trigger autoimmune diseases. Furthermore, the gut microbiota and their metabolites could regulate immune cells and cytokine release via epigenetic modifications, suggesting their possible role in autoimmune disease development. In this chapter we clarify the role of the gut microbiota in autoimmunity and elucidate the proposed new therapeutic approaches to treat autoimmune diseases.
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spelling The gut microbiome in autoimmune diseasesAutoimmunityBarrier disruptionDysbiosisGut microbiomeInflammationMultiple sclerosisProbioticsRheumatoid arthritisSystemic lupus erythematosusType 1 diabetesDysbiosis observed in autoimmune diseases is associated with decreased bacteria function and diversity, impaired epithelial barrier, bacterial translocation, inflammation, and decreased regulatory T cells (Tregs) in the gut mucosa. The hypotheses proposed to link dysbiosis with autoimmune diseases include molecular mimicry, bystander T cell activation, perpetuation of autoimmunity by inflammatory milieu, T helper 17/Tregs imbalance, and the posttranslational modification of luminal proteins (PTMP) induced by enzymes from dysbiotic microbiota, which modify substrates in a different way than under eubiotic conditions. The defective PTMP might generate neoepitopes that become immunogenic and induce systemic autoimmunity and trigger autoimmune diseases. Furthermore, the gut microbiota and their metabolites could regulate immune cells and cytokine release via epigenetic modifications, suggesting their possible role in autoimmune disease development. In this chapter we clarify the role of the gut microbiota in autoimmunity and elucidate the proposed new therapeutic approaches to treat autoimmune diseases.Microbiome Study Group School of Health Sciences Paulo Prata (FACISB)Microbiology Department São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (IBILCE)Microbiology Department São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (IBILCE)Universidade Estadual Paulista (Unesp)de Oliveira, Gislane Lellis Vilela [UNESP]2020-12-12T02:00:27Z2020-12-12T02:00:27Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart325-332http://dx.doi.org/10.1016/B978-0-12-815249-2.00033-6Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications, p. 325-332.http://hdl.handle.net/11449/20020810.1016/B978-0-12-815249-2.00033-62-s2.0-85082341126Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMicrobiome and Metabolome in Diagnosis, Therapy, and other Strategic Applicationsinfo:eu-repo/semantics/openAccess2021-10-23T12:31:26Zoai:repositorio.unesp.br:11449/200208Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:52:50.011413Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The gut microbiome in autoimmune diseases
title The gut microbiome in autoimmune diseases
spellingShingle The gut microbiome in autoimmune diseases
de Oliveira, Gislane Lellis Vilela [UNESP]
Autoimmunity
Barrier disruption
Dysbiosis
Gut microbiome
Inflammation
Multiple sclerosis
Probiotics
Rheumatoid arthritis
Systemic lupus erythematosus
Type 1 diabetes
title_short The gut microbiome in autoimmune diseases
title_full The gut microbiome in autoimmune diseases
title_fullStr The gut microbiome in autoimmune diseases
title_full_unstemmed The gut microbiome in autoimmune diseases
title_sort The gut microbiome in autoimmune diseases
author de Oliveira, Gislane Lellis Vilela [UNESP]
author_facet de Oliveira, Gislane Lellis Vilela [UNESP]
author_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Oliveira, Gislane Lellis Vilela [UNESP]
dc.subject.por.fl_str_mv Autoimmunity
Barrier disruption
Dysbiosis
Gut microbiome
Inflammation
Multiple sclerosis
Probiotics
Rheumatoid arthritis
Systemic lupus erythematosus
Type 1 diabetes
topic Autoimmunity
Barrier disruption
Dysbiosis
Gut microbiome
Inflammation
Multiple sclerosis
Probiotics
Rheumatoid arthritis
Systemic lupus erythematosus
Type 1 diabetes
description Dysbiosis observed in autoimmune diseases is associated with decreased bacteria function and diversity, impaired epithelial barrier, bacterial translocation, inflammation, and decreased regulatory T cells (Tregs) in the gut mucosa. The hypotheses proposed to link dysbiosis with autoimmune diseases include molecular mimicry, bystander T cell activation, perpetuation of autoimmunity by inflammatory milieu, T helper 17/Tregs imbalance, and the posttranslational modification of luminal proteins (PTMP) induced by enzymes from dysbiotic microbiota, which modify substrates in a different way than under eubiotic conditions. The defective PTMP might generate neoepitopes that become immunogenic and induce systemic autoimmunity and trigger autoimmune diseases. Furthermore, the gut microbiota and their metabolites could regulate immune cells and cytokine release via epigenetic modifications, suggesting their possible role in autoimmune disease development. In this chapter we clarify the role of the gut microbiota in autoimmunity and elucidate the proposed new therapeutic approaches to treat autoimmune diseases.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
2020-12-12T02:00:27Z
2020-12-12T02:00:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/B978-0-12-815249-2.00033-6
Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications, p. 325-332.
http://hdl.handle.net/11449/200208
10.1016/B978-0-12-815249-2.00033-6
2-s2.0-85082341126
url http://dx.doi.org/10.1016/B978-0-12-815249-2.00033-6
http://hdl.handle.net/11449/200208
identifier_str_mv Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications, p. 325-332.
10.1016/B978-0-12-815249-2.00033-6
2-s2.0-85082341126
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 325-332
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129368906530816

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