Avaliação da atividade anti-inflamatória intestinal do extrato hidroalcoólico de Solanum paniculatum L. (Solanaceae)

• Autor(a) principal: Mori, Cristiane [UNESP]
• Data de Publicação: 2016
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/203877; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2019-01-28/000898462.pdf
• topic: Agentes anti-inflamatórios; Doenças inflamatórias intestinais; Plantas medicinais; Solanácea; Ervas - Uso terapêutico; Inflammatory bowel deseases

Inflammatory bowel disease is a term related to two distinct diseases, ulcerative colitis (UC) and Crohn's disease (CD), both diseases are characterized by chronic inflammation that compromise structurally and functionally the gastrointestinal tract. Its etiology is unknown, current treatments do not provide ultimate healing and brings numerous side effects, demonstrating the need of new therapeutic strategies, and the use of natural products is one of the most promising. Solanum paniculatum L., family Solanaceae, popularly known as jurubeba, is a plant with different medicinal uses and wide distribution in Brazil, popularly used in controlling arthritis (chronic inflammation), liver and gastrointestinal disorders. Hydroalcoholic extracts of S. paniculatum leaves were administered orally in four doses: 62.5 mg/kg, 125 mg/kg, 250 mg/kg and 500 mg/kg for 5 consecutive days. After this treatment, the induction of the inflammatory process was made by rectal administration of 0.25 ml solution of 10 mg TNBS acid in 50% ethanol (v/v). After 48 hours since induction of the inflammatory process, animals were killed and the colons were removed for macroscopic (lesion length and lesion score, colonic weight -length ratio, adherence to adjacent organs and diarrhea) and biochemical (total content of glutathione, myeloperoxidase and alkaline phosphatase enzyme activities) analyses. Results show that at the doses used the hydroalcoholic extract of Solanum paniculatum L. does not produced protective effect on the TNBS-induced colonic inflammation, suggesting no anti-inflammatory effect at the evaluated doses