The effect of amoxicillin on dental enamel development in vivo
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1807-3107bor-2020.vol34.0116 http://hdl.handle.net/11449/207986 |
Resumo: | The exposure to amoxicillin has been associated with molar incisor hypomineralization. This study aimed to determine if amoxicillin disturbs the enamel mineralization in in vivo experiments. Fifteen pregnant rats were randomly assigned into three groups to received daily phosphatase-buffered saline or amoxicillin as either 100 or 500 mg/kg. Mice received treatment from day 13 of pregnancy to day 40 postnatal. After birth, the offsprings from each litter continued to receive the same treatment according to their respective group. Calcium (Ca) and phosphorus (P) content in the dental hard tissues were analyzed from 60 upper first molars and 60 upper incisors by the complexometric titration method and colorimetric analysis using a spectrophotometer at 680 nm, respectively. Lower incisors were analyzed by X-ray microtomography, it was measured the electron density of lingual and buccal enamel, and the enamel and dentin thickness. Differences in Ca and P content and electron density among the groups were analyzed by one-way ANOVA. There was no significant difference on enamel electron density and thickness among the groups (p > 0.05). However, in incisors, the higher dose of amoxicillin decreased markedly the electron density in some rats. There were no statistically significant differences in Ca (p = 0.180) or P content (p = 0.054), although the higher dose of amoxicillin could affect the enamel in some animals. The amoxicillin did not significantly alter the enamel mineralization and thickness in rats. |
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The effect of amoxicillin on dental enamel development in vivoAmelogenesisAmoxicillinDental EnamelDental Enamel HypoplasiaX-Ray MicrotomographyThe exposure to amoxicillin has been associated with molar incisor hypomineralization. This study aimed to determine if amoxicillin disturbs the enamel mineralization in in vivo experiments. Fifteen pregnant rats were randomly assigned into three groups to received daily phosphatase-buffered saline or amoxicillin as either 100 or 500 mg/kg. Mice received treatment from day 13 of pregnancy to day 40 postnatal. After birth, the offsprings from each litter continued to receive the same treatment according to their respective group. Calcium (Ca) and phosphorus (P) content in the dental hard tissues were analyzed from 60 upper first molars and 60 upper incisors by the complexometric titration method and colorimetric analysis using a spectrophotometer at 680 nm, respectively. Lower incisors were analyzed by X-ray microtomography, it was measured the electron density of lingual and buccal enamel, and the enamel and dentin thickness. Differences in Ca and P content and electron density among the groups were analyzed by one-way ANOVA. There was no significant difference on enamel electron density and thickness among the groups (p > 0.05). However, in incisors, the higher dose of amoxicillin decreased markedly the electron density in some rats. There were no statistically significant differences in Ca (p = 0.180) or P content (p = 0.054), although the higher dose of amoxicillin could affect the enamel in some animals. The amoxicillin did not significantly alter the enamel mineralization and thickness in rats.Universidade Federal do Parana - UFPR Department of Stomatology PR Universidade Federal do ParanaUniversidade Estadual Paulista-Unesp School of Dentistry Department of Pediatric DentistryUniversity of Helsinki School of Medicine Department of Oral and Maxillofacial DiseasesUniversity of Helsinki Institute of Biotechnology Developmental Biology ProgramUniversidade Estadual Paulista-Unesp School of Dentistry Department of MorphologyUniversidade Estadual Paulista-Unesp School of Dentistry Department of Pediatric DentistryUniversidade Estadual Paulista-Unesp School of Dentistry Department of MorphologyUniversidade Federal do Paraná (UFPR)Universidade Estadual Paulista (Unesp)School of MedicineDevelopmental Biology ProgramFELTRIN-SOUZA, JulianaJEREMIAS, Fabiano [UNESP]ALALUUSUA, SatuSAHLBERG, CarinSANTOS-PINTO, Lourdes [UNESP]JERNVALL, JukkaSOVA, SusannaCORDEIRO, Rita de Cassia Loiola [UNESP]CERRI, Paulo Sergio [UNESP]2021-06-25T11:04:29Z2021-06-25T11:04:29Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-9application/pdfhttp://dx.doi.org/10.1590/1807-3107bor-2020.vol34.0116Brazilian Oral Research, v. 34, p. 1-9.1807-31071806-8324http://hdl.handle.net/11449/20798610.1590/1807-3107bor-2020.vol34.0116S1806-832420200001002872-s2.0-85091442024S1806-83242020000100287.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Oral Researchinfo:eu-repo/semantics/openAccess2023-11-30T06:17:48Zoai:repositorio.unesp.br:11449/207986Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:09:38.233523Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The effect of amoxicillin on dental enamel development in vivo |
title |
The effect of amoxicillin on dental enamel development in vivo |
spellingShingle |
The effect of amoxicillin on dental enamel development in vivo FELTRIN-SOUZA, Juliana Amelogenesis Amoxicillin Dental Enamel Dental Enamel Hypoplasia X-Ray Microtomography |
title_short |
The effect of amoxicillin on dental enamel development in vivo |
title_full |
The effect of amoxicillin on dental enamel development in vivo |
title_fullStr |
The effect of amoxicillin on dental enamel development in vivo |
title_full_unstemmed |
The effect of amoxicillin on dental enamel development in vivo |
title_sort |
The effect of amoxicillin on dental enamel development in vivo |
author |
FELTRIN-SOUZA, Juliana |
author_facet |
FELTRIN-SOUZA, Juliana JEREMIAS, Fabiano [UNESP] ALALUUSUA, Satu SAHLBERG, Carin SANTOS-PINTO, Lourdes [UNESP] JERNVALL, Jukka SOVA, Susanna CORDEIRO, Rita de Cassia Loiola [UNESP] CERRI, Paulo Sergio [UNESP] |
author_role |
author |
author2 |
JEREMIAS, Fabiano [UNESP] ALALUUSUA, Satu SAHLBERG, Carin SANTOS-PINTO, Lourdes [UNESP] JERNVALL, Jukka SOVA, Susanna CORDEIRO, Rita de Cassia Loiola [UNESP] CERRI, Paulo Sergio [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Paraná (UFPR) Universidade Estadual Paulista (Unesp) School of Medicine Developmental Biology Program |
dc.contributor.author.fl_str_mv |
FELTRIN-SOUZA, Juliana JEREMIAS, Fabiano [UNESP] ALALUUSUA, Satu SAHLBERG, Carin SANTOS-PINTO, Lourdes [UNESP] JERNVALL, Jukka SOVA, Susanna CORDEIRO, Rita de Cassia Loiola [UNESP] CERRI, Paulo Sergio [UNESP] |
dc.subject.por.fl_str_mv |
Amelogenesis Amoxicillin Dental Enamel Dental Enamel Hypoplasia X-Ray Microtomography |
topic |
Amelogenesis Amoxicillin Dental Enamel Dental Enamel Hypoplasia X-Ray Microtomography |
description |
The exposure to amoxicillin has been associated with molar incisor hypomineralization. This study aimed to determine if amoxicillin disturbs the enamel mineralization in in vivo experiments. Fifteen pregnant rats were randomly assigned into three groups to received daily phosphatase-buffered saline or amoxicillin as either 100 or 500 mg/kg. Mice received treatment from day 13 of pregnancy to day 40 postnatal. After birth, the offsprings from each litter continued to receive the same treatment according to their respective group. Calcium (Ca) and phosphorus (P) content in the dental hard tissues were analyzed from 60 upper first molars and 60 upper incisors by the complexometric titration method and colorimetric analysis using a spectrophotometer at 680 nm, respectively. Lower incisors were analyzed by X-ray microtomography, it was measured the electron density of lingual and buccal enamel, and the enamel and dentin thickness. Differences in Ca and P content and electron density among the groups were analyzed by one-way ANOVA. There was no significant difference on enamel electron density and thickness among the groups (p > 0.05). However, in incisors, the higher dose of amoxicillin decreased markedly the electron density in some rats. There were no statistically significant differences in Ca (p = 0.180) or P content (p = 0.054), although the higher dose of amoxicillin could affect the enamel in some animals. The amoxicillin did not significantly alter the enamel mineralization and thickness in rats. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 2021-06-25T11:04:29Z 2021-06-25T11:04:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1807-3107bor-2020.vol34.0116 Brazilian Oral Research, v. 34, p. 1-9. 1807-3107 1806-8324 http://hdl.handle.net/11449/207986 10.1590/1807-3107bor-2020.vol34.0116 S1806-83242020000100287 2-s2.0-85091442024 S1806-83242020000100287.pdf |
url |
http://dx.doi.org/10.1590/1807-3107bor-2020.vol34.0116 http://hdl.handle.net/11449/207986 |
identifier_str_mv |
Brazilian Oral Research, v. 34, p. 1-9. 1807-3107 1806-8324 10.1590/1807-3107bor-2020.vol34.0116 S1806-83242020000100287 2-s2.0-85091442024 S1806-83242020000100287.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Oral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-9 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129027974627328 |