Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0103-50532008000100023 http://hdl.handle.net/11449/26287 |
Resumo: | The characteristics, performance, and application of an electrode, namely, Pt vertical bar Hg vertical bar Hg-2(FF)(2)vertical bar Graphite, where FF stands for flufenamate ion, are described. This electrode responds to FF with sensitivity of (-58.6 +/- 1.2) mV decade(-1) over the range 1.0 x 10(-6) - 1.0 x 10(-2) mol L-1 at pH 6.0-9.0 and a detection limit of 7.1 x 10(-7) mol L-1. The electrode is easily constructed at a relatively low cost with fast response time (within 10-25 s) and can be used for a period of 5 months without any considerable change in its performance characteristics. The proposed electrode displayed good selectivity for flufenamate in the presence of several substances as well as in the presence of some carboxylate and inorganic anions. The electrode was successfully applied to the determination of flufenamic acid in pharmaceuticals and human serum samples. |
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Repositório Institucional da UNESP |
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Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analysesflufenamate-sensitive electrodepotentiometrydosage formsblood serumThe characteristics, performance, and application of an electrode, namely, Pt vertical bar Hg vertical bar Hg-2(FF)(2)vertical bar Graphite, where FF stands for flufenamate ion, are described. This electrode responds to FF with sensitivity of (-58.6 +/- 1.2) mV decade(-1) over the range 1.0 x 10(-6) - 1.0 x 10(-2) mol L-1 at pH 6.0-9.0 and a detection limit of 7.1 x 10(-7) mol L-1. The electrode is easily constructed at a relatively low cost with fast response time (within 10-25 s) and can be used for a period of 5 months without any considerable change in its performance characteristics. The proposed electrode displayed good selectivity for flufenamate in the presence of several substances as well as in the presence of some carboxylate and inorganic anions. The electrode was successfully applied to the determination of flufenamic acid in pharmaceuticals and human serum samples.Univ Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, BrazilUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, BrazilSoc Brasileira QuimicaUniversidade Estadual Paulista (Unesp)Santini, A. O. [UNESP]Pezza, Helena Redigolo [UNESP]Oliveira, Jose Eduardo de [UNESP]Pezza, Leonardo [UNESP]2014-05-20T14:20:58Z2014-05-20T14:20:58Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article162-168application/pdfhttp://dx.doi.org/10.1590/S0103-50532008000100023Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 19, n. 1, p. 162-168, 2008.0103-5053http://hdl.handle.net/11449/2628710.1590/S0103-50532008000100023S0103-50532008000100023WOS:000254682500022S0103-50532008000100023.pdf3192125098361121935214137936387759789085918535240000-0003-0197-7369Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,357info:eu-repo/semantics/openAccess2023-12-04T06:15:28Zoai:repositorio.unesp.br:11449/26287Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:29:10.663210Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses |
title |
Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses |
spellingShingle |
Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses Santini, A. O. [UNESP] flufenamate-sensitive electrode potentiometry dosage forms blood serum |
title_short |
Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses |
title_full |
Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses |
title_fullStr |
Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses |
title_full_unstemmed |
Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses |
title_sort |
Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses |
author |
Santini, A. O. [UNESP] |
author_facet |
Santini, A. O. [UNESP] Pezza, Helena Redigolo [UNESP] Oliveira, Jose Eduardo de [UNESP] Pezza, Leonardo [UNESP] |
author_role |
author |
author2 |
Pezza, Helena Redigolo [UNESP] Oliveira, Jose Eduardo de [UNESP] Pezza, Leonardo [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Santini, A. O. [UNESP] Pezza, Helena Redigolo [UNESP] Oliveira, Jose Eduardo de [UNESP] Pezza, Leonardo [UNESP] |
dc.subject.por.fl_str_mv |
flufenamate-sensitive electrode potentiometry dosage forms blood serum |
topic |
flufenamate-sensitive electrode potentiometry dosage forms blood serum |
description |
The characteristics, performance, and application of an electrode, namely, Pt vertical bar Hg vertical bar Hg-2(FF)(2)vertical bar Graphite, where FF stands for flufenamate ion, are described. This electrode responds to FF with sensitivity of (-58.6 +/- 1.2) mV decade(-1) over the range 1.0 x 10(-6) - 1.0 x 10(-2) mol L-1 at pH 6.0-9.0 and a detection limit of 7.1 x 10(-7) mol L-1. The electrode is easily constructed at a relatively low cost with fast response time (within 10-25 s) and can be used for a period of 5 months without any considerable change in its performance characteristics. The proposed electrode displayed good selectivity for flufenamate in the presence of several substances as well as in the presence of some carboxylate and inorganic anions. The electrode was successfully applied to the determination of flufenamic acid in pharmaceuticals and human serum samples. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 2014-05-20T14:20:58Z 2014-05-20T14:20:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0103-50532008000100023 Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 19, n. 1, p. 162-168, 2008. 0103-5053 http://hdl.handle.net/11449/26287 10.1590/S0103-50532008000100023 S0103-50532008000100023 WOS:000254682500022 S0103-50532008000100023.pdf 3192125098361121 9352141379363877 5978908591853524 0000-0003-0197-7369 |
url |
http://dx.doi.org/10.1590/S0103-50532008000100023 http://hdl.handle.net/11449/26287 |
identifier_str_mv |
Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 19, n. 1, p. 162-168, 2008. 0103-5053 10.1590/S0103-50532008000100023 S0103-50532008000100023 WOS:000254682500022 S0103-50532008000100023.pdf 3192125098361121 9352141379363877 5978908591853524 0000-0003-0197-7369 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society 1.444 0,357 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
162-168 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasileira Quimica |
publisher.none.fl_str_mv |
Soc Brasileira Quimica |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129075610386432 |