Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury

Detalhes bibliográficos
Autor(a) principal: Macruz, Fabiola Bezerra de Carvalho
Data de Publicação: 2022
Outros Autores: Feltrin, Fabrício Stewan, Zaninotto, Ana, Guirado, Vinícius Monteiro de Paula, Otaduy, Maria Concepcion Garcia, Tsunemi, Miriam Harumi [UNESP], Nucci, Mariana Penteado, Rimkus, Carolina, Andrade, Celi Santos, Leite, Claudia da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1002/brb3.2490
http://hdl.handle.net/11449/230326
Resumo: Background: Diffuse axonal injury (DAI) is a frequent mechanism of traumatic brain injury (TBI) that triggers a sequence of parenchymal changes that progresses from focal axonal shear injuries up to inflammatory response and delayed axonal disconnection. Objective: The main purpose of this study is to evaluate changes in the axonal/myelinic content and the brain volume up to 12 months after TBI and to correlate these changes with neuropsychological results. Methods: Patients with DAI (n = 25) were scanned at three time points after trauma (2, 6, and 12 months), and the total brain volume (TBV), gray matter volume, and white matter volume (WMV) were calculated in each time point. The magnetization transfer ratio (MTR) for the total brain (TB MTR), gray matter (GM MTR), and white matter (WM MTR) was also quantified. In addition, Hopkins verbal learning test (HVLT), Trail Making Test (TMT), and Rey–Osterrieth Complex Figure test were performed at 6 and 12 months after the trauma. Results: There was a significant reduction in the mean TBV, WMV, TB MTR, GM MTR, and WM MTR between time points 1 and 3 (p <.05). There was also a significant difference in HVLT-immediate, TMT-A, and TMT-B scores between time points 2 and 3. The MTR decline correlated more with the cognitive dysfunction than the volume reduction. Conclusion: A progressive axonal/myelinic rarefaction and volume loss were characterized, especially in the white matter (WM) up to 1 year after the trauma. Despite that, specific neuropsychological tests revealed that patients’ episodic verbal memory, attention, and executive function improved during the study. The current findings may be valuable in developing long-term TBI rehabilitation management programs.
id UNSP_ee540f6693abdc7e9b3b0a32f1d80dda
oai_identifier_str oai:repositorio.unesp.br:11449/230326
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injuryBackground: Diffuse axonal injury (DAI) is a frequent mechanism of traumatic brain injury (TBI) that triggers a sequence of parenchymal changes that progresses from focal axonal shear injuries up to inflammatory response and delayed axonal disconnection. Objective: The main purpose of this study is to evaluate changes in the axonal/myelinic content and the brain volume up to 12 months after TBI and to correlate these changes with neuropsychological results. Methods: Patients with DAI (n = 25) were scanned at three time points after trauma (2, 6, and 12 months), and the total brain volume (TBV), gray matter volume, and white matter volume (WMV) were calculated in each time point. The magnetization transfer ratio (MTR) for the total brain (TB MTR), gray matter (GM MTR), and white matter (WM MTR) was also quantified. In addition, Hopkins verbal learning test (HVLT), Trail Making Test (TMT), and Rey–Osterrieth Complex Figure test were performed at 6 and 12 months after the trauma. Results: There was a significant reduction in the mean TBV, WMV, TB MTR, GM MTR, and WM MTR between time points 1 and 3 (p <.05). There was also a significant difference in HVLT-immediate, TMT-A, and TMT-B scores between time points 2 and 3. The MTR decline correlated more with the cognitive dysfunction than the volume reduction. Conclusion: A progressive axonal/myelinic rarefaction and volume loss were characterized, especially in the white matter (WM) up to 1 year after the trauma. Despite that, specific neuropsychological tests revealed that patients’ episodic verbal memory, attention, and executive function improved during the study. The current findings may be valuable in developing long-term TBI rehabilitation management programs.Department of Radiology and Oncology Hospital das Clínicas Faculdade de Medicina da USPNeuropsychology Division Department of Neurology Hospital das Clínicas Faculdade de Medicina da USPNeurosurgery Division Department of Neurology Hospital das Clínicas Faculdade de Medicina da USPDepartment of Biostatistics Universidade Estadual Paulista BotucatuDepartment of Biostatistics Universidade Estadual Paulista BotucatuUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Macruz, Fabiola Bezerra de CarvalhoFeltrin, Fabrício StewanZaninotto, AnaGuirado, Vinícius Monteiro de PaulaOtaduy, Maria Concepcion GarciaTsunemi, Miriam Harumi [UNESP]Nucci, Mariana PenteadoRimkus, CarolinaAndrade, Celi SantosLeite, Claudia da Costa2022-04-29T08:39:20Z2022-04-29T08:39:20Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/brb3.2490Brain and Behavior.2162-3279http://hdl.handle.net/11449/23032610.1002/brb3.24902-s2.0-85123931569Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrain and Behaviorinfo:eu-repo/semantics/openAccess2022-04-29T08:39:20Zoai:repositorio.unesp.br:11449/230326Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:59:08.039646Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
title Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
spellingShingle Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
Macruz, Fabiola Bezerra de Carvalho
title_short Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
title_full Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
title_fullStr Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
title_full_unstemmed Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
title_sort Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
author Macruz, Fabiola Bezerra de Carvalho
author_facet Macruz, Fabiola Bezerra de Carvalho
Feltrin, Fabrício Stewan
Zaninotto, Ana
Guirado, Vinícius Monteiro de Paula
Otaduy, Maria Concepcion Garcia
Tsunemi, Miriam Harumi [UNESP]
Nucci, Mariana Penteado
Rimkus, Carolina
Andrade, Celi Santos
Leite, Claudia da Costa
author_role author
author2 Feltrin, Fabrício Stewan
Zaninotto, Ana
Guirado, Vinícius Monteiro de Paula
Otaduy, Maria Concepcion Garcia
Tsunemi, Miriam Harumi [UNESP]
Nucci, Mariana Penteado
Rimkus, Carolina
Andrade, Celi Santos
Leite, Claudia da Costa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Macruz, Fabiola Bezerra de Carvalho
Feltrin, Fabrício Stewan
Zaninotto, Ana
Guirado, Vinícius Monteiro de Paula
Otaduy, Maria Concepcion Garcia
Tsunemi, Miriam Harumi [UNESP]
Nucci, Mariana Penteado
Rimkus, Carolina
Andrade, Celi Santos
Leite, Claudia da Costa
description Background: Diffuse axonal injury (DAI) is a frequent mechanism of traumatic brain injury (TBI) that triggers a sequence of parenchymal changes that progresses from focal axonal shear injuries up to inflammatory response and delayed axonal disconnection. Objective: The main purpose of this study is to evaluate changes in the axonal/myelinic content and the brain volume up to 12 months after TBI and to correlate these changes with neuropsychological results. Methods: Patients with DAI (n = 25) were scanned at three time points after trauma (2, 6, and 12 months), and the total brain volume (TBV), gray matter volume, and white matter volume (WMV) were calculated in each time point. The magnetization transfer ratio (MTR) for the total brain (TB MTR), gray matter (GM MTR), and white matter (WM MTR) was also quantified. In addition, Hopkins verbal learning test (HVLT), Trail Making Test (TMT), and Rey–Osterrieth Complex Figure test were performed at 6 and 12 months after the trauma. Results: There was a significant reduction in the mean TBV, WMV, TB MTR, GM MTR, and WM MTR between time points 1 and 3 (p <.05). There was also a significant difference in HVLT-immediate, TMT-A, and TMT-B scores between time points 2 and 3. The MTR decline correlated more with the cognitive dysfunction than the volume reduction. Conclusion: A progressive axonal/myelinic rarefaction and volume loss were characterized, especially in the white matter (WM) up to 1 year after the trauma. Despite that, specific neuropsychological tests revealed that patients’ episodic verbal memory, attention, and executive function improved during the study. The current findings may be valuable in developing long-term TBI rehabilitation management programs.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-29T08:39:20Z
2022-04-29T08:39:20Z
2022-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1002/brb3.2490
Brain and Behavior.
2162-3279
http://hdl.handle.net/11449/230326
10.1002/brb3.2490
2-s2.0-85123931569
url http://dx.doi.org/10.1002/brb3.2490
http://hdl.handle.net/11449/230326
identifier_str_mv Brain and Behavior.
2162-3279
10.1002/brb3.2490
2-s2.0-85123931569
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brain and Behavior
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128590142767104