Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/brb3.2490 http://hdl.handle.net/11449/230326 |
Resumo: | Background: Diffuse axonal injury (DAI) is a frequent mechanism of traumatic brain injury (TBI) that triggers a sequence of parenchymal changes that progresses from focal axonal shear injuries up to inflammatory response and delayed axonal disconnection. Objective: The main purpose of this study is to evaluate changes in the axonal/myelinic content and the brain volume up to 12 months after TBI and to correlate these changes with neuropsychological results. Methods: Patients with DAI (n = 25) were scanned at three time points after trauma (2, 6, and 12 months), and the total brain volume (TBV), gray matter volume, and white matter volume (WMV) were calculated in each time point. The magnetization transfer ratio (MTR) for the total brain (TB MTR), gray matter (GM MTR), and white matter (WM MTR) was also quantified. In addition, Hopkins verbal learning test (HVLT), Trail Making Test (TMT), and Rey–Osterrieth Complex Figure test were performed at 6 and 12 months after the trauma. Results: There was a significant reduction in the mean TBV, WMV, TB MTR, GM MTR, and WM MTR between time points 1 and 3 (p <.05). There was also a significant difference in HVLT-immediate, TMT-A, and TMT-B scores between time points 2 and 3. The MTR decline correlated more with the cognitive dysfunction than the volume reduction. Conclusion: A progressive axonal/myelinic rarefaction and volume loss were characterized, especially in the white matter (WM) up to 1 year after the trauma. Despite that, specific neuropsychological tests revealed that patients’ episodic verbal memory, attention, and executive function improved during the study. The current findings may be valuable in developing long-term TBI rehabilitation management programs. |
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Repositório Institucional da UNESP |
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Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injuryBackground: Diffuse axonal injury (DAI) is a frequent mechanism of traumatic brain injury (TBI) that triggers a sequence of parenchymal changes that progresses from focal axonal shear injuries up to inflammatory response and delayed axonal disconnection. Objective: The main purpose of this study is to evaluate changes in the axonal/myelinic content and the brain volume up to 12 months after TBI and to correlate these changes with neuropsychological results. Methods: Patients with DAI (n = 25) were scanned at three time points after trauma (2, 6, and 12 months), and the total brain volume (TBV), gray matter volume, and white matter volume (WMV) were calculated in each time point. The magnetization transfer ratio (MTR) for the total brain (TB MTR), gray matter (GM MTR), and white matter (WM MTR) was also quantified. In addition, Hopkins verbal learning test (HVLT), Trail Making Test (TMT), and Rey–Osterrieth Complex Figure test were performed at 6 and 12 months after the trauma. Results: There was a significant reduction in the mean TBV, WMV, TB MTR, GM MTR, and WM MTR between time points 1 and 3 (p <.05). There was also a significant difference in HVLT-immediate, TMT-A, and TMT-B scores between time points 2 and 3. The MTR decline correlated more with the cognitive dysfunction than the volume reduction. Conclusion: A progressive axonal/myelinic rarefaction and volume loss were characterized, especially in the white matter (WM) up to 1 year after the trauma. Despite that, specific neuropsychological tests revealed that patients’ episodic verbal memory, attention, and executive function improved during the study. The current findings may be valuable in developing long-term TBI rehabilitation management programs.Department of Radiology and Oncology Hospital das Clínicas Faculdade de Medicina da USPNeuropsychology Division Department of Neurology Hospital das Clínicas Faculdade de Medicina da USPNeurosurgery Division Department of Neurology Hospital das Clínicas Faculdade de Medicina da USPDepartment of Biostatistics Universidade Estadual Paulista BotucatuDepartment of Biostatistics Universidade Estadual Paulista BotucatuUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Macruz, Fabiola Bezerra de CarvalhoFeltrin, Fabrício StewanZaninotto, AnaGuirado, Vinícius Monteiro de PaulaOtaduy, Maria Concepcion GarciaTsunemi, Miriam Harumi [UNESP]Nucci, Mariana PenteadoRimkus, CarolinaAndrade, Celi SantosLeite, Claudia da Costa2022-04-29T08:39:20Z2022-04-29T08:39:20Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/brb3.2490Brain and Behavior.2162-3279http://hdl.handle.net/11449/23032610.1002/brb3.24902-s2.0-85123931569Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrain and Behaviorinfo:eu-repo/semantics/openAccess2022-04-29T08:39:20Zoai:repositorio.unesp.br:11449/230326Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:59:08.039646Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury |
title |
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury |
spellingShingle |
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury Macruz, Fabiola Bezerra de Carvalho |
title_short |
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury |
title_full |
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury |
title_fullStr |
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury |
title_full_unstemmed |
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury |
title_sort |
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury |
author |
Macruz, Fabiola Bezerra de Carvalho |
author_facet |
Macruz, Fabiola Bezerra de Carvalho Feltrin, Fabrício Stewan Zaninotto, Ana Guirado, Vinícius Monteiro de Paula Otaduy, Maria Concepcion Garcia Tsunemi, Miriam Harumi [UNESP] Nucci, Mariana Penteado Rimkus, Carolina Andrade, Celi Santos Leite, Claudia da Costa |
author_role |
author |
author2 |
Feltrin, Fabrício Stewan Zaninotto, Ana Guirado, Vinícius Monteiro de Paula Otaduy, Maria Concepcion Garcia Tsunemi, Miriam Harumi [UNESP] Nucci, Mariana Penteado Rimkus, Carolina Andrade, Celi Santos Leite, Claudia da Costa |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Macruz, Fabiola Bezerra de Carvalho Feltrin, Fabrício Stewan Zaninotto, Ana Guirado, Vinícius Monteiro de Paula Otaduy, Maria Concepcion Garcia Tsunemi, Miriam Harumi [UNESP] Nucci, Mariana Penteado Rimkus, Carolina Andrade, Celi Santos Leite, Claudia da Costa |
description |
Background: Diffuse axonal injury (DAI) is a frequent mechanism of traumatic brain injury (TBI) that triggers a sequence of parenchymal changes that progresses from focal axonal shear injuries up to inflammatory response and delayed axonal disconnection. Objective: The main purpose of this study is to evaluate changes in the axonal/myelinic content and the brain volume up to 12 months after TBI and to correlate these changes with neuropsychological results. Methods: Patients with DAI (n = 25) were scanned at three time points after trauma (2, 6, and 12 months), and the total brain volume (TBV), gray matter volume, and white matter volume (WMV) were calculated in each time point. The magnetization transfer ratio (MTR) for the total brain (TB MTR), gray matter (GM MTR), and white matter (WM MTR) was also quantified. In addition, Hopkins verbal learning test (HVLT), Trail Making Test (TMT), and Rey–Osterrieth Complex Figure test were performed at 6 and 12 months after the trauma. Results: There was a significant reduction in the mean TBV, WMV, TB MTR, GM MTR, and WM MTR between time points 1 and 3 (p <.05). There was also a significant difference in HVLT-immediate, TMT-A, and TMT-B scores between time points 2 and 3. The MTR decline correlated more with the cognitive dysfunction than the volume reduction. Conclusion: A progressive axonal/myelinic rarefaction and volume loss were characterized, especially in the white matter (WM) up to 1 year after the trauma. Despite that, specific neuropsychological tests revealed that patients’ episodic verbal memory, attention, and executive function improved during the study. The current findings may be valuable in developing long-term TBI rehabilitation management programs. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:39:20Z 2022-04-29T08:39:20Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/brb3.2490 Brain and Behavior. 2162-3279 http://hdl.handle.net/11449/230326 10.1002/brb3.2490 2-s2.0-85123931569 |
url |
http://dx.doi.org/10.1002/brb3.2490 http://hdl.handle.net/11449/230326 |
identifier_str_mv |
Brain and Behavior. 2162-3279 10.1002/brb3.2490 2-s2.0-85123931569 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brain and Behavior |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128590142767104 |