Treatment of osteochondral injuries with platelet gel

Detalhes bibliográficos
Autor(a) principal: Danieli, Marcus Vinicius [UNESP]
Data de Publicação: 2014
Outros Autores: Pereira, Hamilton da Rosa [UNESP], Sa Carneiro, Carlos Augusto de [UNESP], Felisbino, Sergio Luiz [UNESP], Deffune, Elenice [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.6061/clinics/2014(10)08
http://hdl.handle.net/11449/117637
Resumo: OBJECTIVES: Treatments for injured articular cartilage have not advanced to the point that efficient regeneration is possible. However, there has been an increase in the use of platelet-rich plasma for the treatment of several orthopedic disorders, including chondral injuries. Our hypothesis is that the treatment of chondral injuries with platelet gel results in higher-quality repair tissue after 180 days compared with chondral injuries not treated with gel.METHODS: A controlled experimental laboratory study was performed on 30 male rabbits to evaluate osteochondral injury repair after treatment with or without platelet gel. Osteochondral injuries were surgically induced in both knees of each rabbit at the medial femoral condyle. The left knee injury was filled with the platelet gel, and the right knee was not treated. Microscopic analysis of both knee samples was performed after 180 days using a histological grading scale.RESULTS: The only histological evaluation criterion that was not significantly different between treatments was metachromasia. The group that was treated with platelet gel exhibited superior results in all other criteria (cell morphology, surface regularity, chondral thickness and repair tissue integration) and in the total score.CONCLUSION: The repair tissue was histologically superior after 180 days in the study group treated with platelet gel compared with the group of untreated injuries.
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spelling Treatment of osteochondral injuries with platelet gelPlatelet-Rich PlasmaArticular CartilageInjuriesRegenerative MedicineOBJECTIVES: Treatments for injured articular cartilage have not advanced to the point that efficient regeneration is possible. However, there has been an increase in the use of platelet-rich plasma for the treatment of several orthopedic disorders, including chondral injuries. Our hypothesis is that the treatment of chondral injuries with platelet gel results in higher-quality repair tissue after 180 days compared with chondral injuries not treated with gel.METHODS: A controlled experimental laboratory study was performed on 30 male rabbits to evaluate osteochondral injury repair after treatment with or without platelet gel. Osteochondral injuries were surgically induced in both knees of each rabbit at the medial femoral condyle. The left knee injury was filled with the platelet gel, and the right knee was not treated. Microscopic analysis of both knee samples was performed after 180 days using a histological grading scale.RESULTS: The only histological evaluation criterion that was not significantly different between treatments was metachromasia. The group that was treated with platelet gel exhibited superior results in all other criteria (cell morphology, surface regularity, chondral thickness and repair tissue integration) and in the total score.CONCLUSION: The repair tissue was histologically superior after 180 days in the study group treated with platelet gel compared with the group of untreated injuries.Private Clin & Hosp, Uniort e Ortopedia Especializada, Londrina, PR, BrazilUniv Estadual Paulista, Fac Med Botucatu, UNESP, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biosci, UNESP, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, UNESP, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biosci, UNESP, Botucatu, SP, BrazilHospital Clinicas, Univ Sao PauloPrivate Clin & HospUniversidade Estadual Paulista (Unesp)Danieli, Marcus Vinicius [UNESP]Pereira, Hamilton da Rosa [UNESP]Sa Carneiro, Carlos Augusto de [UNESP]Felisbino, Sergio Luiz [UNESP]Deffune, Elenice [UNESP]2015-03-18T15:56:36Z2015-03-18T15:56:36Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article694-698application/pdfhttp://dx.doi.org/10.6061/clinics/2014(10)08Clinics. Sao Paulo: Hospital Clinicas, Univ Sao Paulo, v. 69, n. 10, p. 694-698, 2014.1807-5932http://hdl.handle.net/11449/11763710.6061/clinics/2014(10)08WOS:000346073000008WOS000346073000008.pdf79222652745520649646764071339214Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics1.2450,536info:eu-repo/semantics/openAccess2024-09-03T14:29:55Zoai:repositorio.unesp.br:11449/117637Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:29:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Treatment of osteochondral injuries with platelet gel
title Treatment of osteochondral injuries with platelet gel
spellingShingle Treatment of osteochondral injuries with platelet gel
Danieli, Marcus Vinicius [UNESP]
Platelet-Rich Plasma
Articular Cartilage
Injuries
Regenerative Medicine
title_short Treatment of osteochondral injuries with platelet gel
title_full Treatment of osteochondral injuries with platelet gel
title_fullStr Treatment of osteochondral injuries with platelet gel
title_full_unstemmed Treatment of osteochondral injuries with platelet gel
title_sort Treatment of osteochondral injuries with platelet gel
author Danieli, Marcus Vinicius [UNESP]
author_facet Danieli, Marcus Vinicius [UNESP]
Pereira, Hamilton da Rosa [UNESP]
Sa Carneiro, Carlos Augusto de [UNESP]
Felisbino, Sergio Luiz [UNESP]
Deffune, Elenice [UNESP]
author_role author
author2 Pereira, Hamilton da Rosa [UNESP]
Sa Carneiro, Carlos Augusto de [UNESP]
Felisbino, Sergio Luiz [UNESP]
Deffune, Elenice [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Private Clin & Hosp
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Danieli, Marcus Vinicius [UNESP]
Pereira, Hamilton da Rosa [UNESP]
Sa Carneiro, Carlos Augusto de [UNESP]
Felisbino, Sergio Luiz [UNESP]
Deffune, Elenice [UNESP]
dc.subject.por.fl_str_mv Platelet-Rich Plasma
Articular Cartilage
Injuries
Regenerative Medicine
topic Platelet-Rich Plasma
Articular Cartilage
Injuries
Regenerative Medicine
description OBJECTIVES: Treatments for injured articular cartilage have not advanced to the point that efficient regeneration is possible. However, there has been an increase in the use of platelet-rich plasma for the treatment of several orthopedic disorders, including chondral injuries. Our hypothesis is that the treatment of chondral injuries with platelet gel results in higher-quality repair tissue after 180 days compared with chondral injuries not treated with gel.METHODS: A controlled experimental laboratory study was performed on 30 male rabbits to evaluate osteochondral injury repair after treatment with or without platelet gel. Osteochondral injuries were surgically induced in both knees of each rabbit at the medial femoral condyle. The left knee injury was filled with the platelet gel, and the right knee was not treated. Microscopic analysis of both knee samples was performed after 180 days using a histological grading scale.RESULTS: The only histological evaluation criterion that was not significantly different between treatments was metachromasia. The group that was treated with platelet gel exhibited superior results in all other criteria (cell morphology, surface regularity, chondral thickness and repair tissue integration) and in the total score.CONCLUSION: The repair tissue was histologically superior after 180 days in the study group treated with platelet gel compared with the group of untreated injuries.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
2015-03-18T15:56:36Z
2015-03-18T15:56:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.6061/clinics/2014(10)08
Clinics. Sao Paulo: Hospital Clinicas, Univ Sao Paulo, v. 69, n. 10, p. 694-698, 2014.
1807-5932
http://hdl.handle.net/11449/117637
10.6061/clinics/2014(10)08
WOS:000346073000008
WOS000346073000008.pdf
7922265274552064
9646764071339214
url http://dx.doi.org/10.6061/clinics/2014(10)08
http://hdl.handle.net/11449/117637
identifier_str_mv Clinics. Sao Paulo: Hospital Clinicas, Univ Sao Paulo, v. 69, n. 10, p. 694-698, 2014.
1807-5932
10.6061/clinics/2014(10)08
WOS:000346073000008
WOS000346073000008.pdf
7922265274552064
9646764071339214
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
1.245
0,536
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 694-698
application/pdf
dc.publisher.none.fl_str_mv Hospital Clinicas, Univ Sao Paulo
publisher.none.fl_str_mv Hospital Clinicas, Univ Sao Paulo
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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