Treatment of osteochondral injuries with platelet gel
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.6061/clinics/2014(10)08 http://hdl.handle.net/11449/117637 |
Resumo: | OBJECTIVES: Treatments for injured articular cartilage have not advanced to the point that efficient regeneration is possible. However, there has been an increase in the use of platelet-rich plasma for the treatment of several orthopedic disorders, including chondral injuries. Our hypothesis is that the treatment of chondral injuries with platelet gel results in higher-quality repair tissue after 180 days compared with chondral injuries not treated with gel.METHODS: A controlled experimental laboratory study was performed on 30 male rabbits to evaluate osteochondral injury repair after treatment with or without platelet gel. Osteochondral injuries were surgically induced in both knees of each rabbit at the medial femoral condyle. The left knee injury was filled with the platelet gel, and the right knee was not treated. Microscopic analysis of both knee samples was performed after 180 days using a histological grading scale.RESULTS: The only histological evaluation criterion that was not significantly different between treatments was metachromasia. The group that was treated with platelet gel exhibited superior results in all other criteria (cell morphology, surface regularity, chondral thickness and repair tissue integration) and in the total score.CONCLUSION: The repair tissue was histologically superior after 180 days in the study group treated with platelet gel compared with the group of untreated injuries. |
id |
UNSP_eff03a47a4237b93d3b3cc79c136e648 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/117637 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Treatment of osteochondral injuries with platelet gelPlatelet-Rich PlasmaArticular CartilageInjuriesRegenerative MedicineOBJECTIVES: Treatments for injured articular cartilage have not advanced to the point that efficient regeneration is possible. However, there has been an increase in the use of platelet-rich plasma for the treatment of several orthopedic disorders, including chondral injuries. Our hypothesis is that the treatment of chondral injuries with platelet gel results in higher-quality repair tissue after 180 days compared with chondral injuries not treated with gel.METHODS: A controlled experimental laboratory study was performed on 30 male rabbits to evaluate osteochondral injury repair after treatment with or without platelet gel. Osteochondral injuries were surgically induced in both knees of each rabbit at the medial femoral condyle. The left knee injury was filled with the platelet gel, and the right knee was not treated. Microscopic analysis of both knee samples was performed after 180 days using a histological grading scale.RESULTS: The only histological evaluation criterion that was not significantly different between treatments was metachromasia. The group that was treated with platelet gel exhibited superior results in all other criteria (cell morphology, surface regularity, chondral thickness and repair tissue integration) and in the total score.CONCLUSION: The repair tissue was histologically superior after 180 days in the study group treated with platelet gel compared with the group of untreated injuries.Private Clin & Hosp, Uniort e Ortopedia Especializada, Londrina, PR, BrazilUniv Estadual Paulista, Fac Med Botucatu, UNESP, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biosci, UNESP, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, UNESP, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biosci, UNESP, Botucatu, SP, BrazilHospital Clinicas, Univ Sao PauloPrivate Clin & HospUniversidade Estadual Paulista (Unesp)Danieli, Marcus Vinicius [UNESP]Pereira, Hamilton da Rosa [UNESP]Sa Carneiro, Carlos Augusto de [UNESP]Felisbino, Sergio Luiz [UNESP]Deffune, Elenice [UNESP]2015-03-18T15:56:36Z2015-03-18T15:56:36Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article694-698application/pdfhttp://dx.doi.org/10.6061/clinics/2014(10)08Clinics. Sao Paulo: Hospital Clinicas, Univ Sao Paulo, v. 69, n. 10, p. 694-698, 2014.1807-5932http://hdl.handle.net/11449/11763710.6061/clinics/2014(10)08WOS:000346073000008WOS000346073000008.pdf79222652745520649646764071339214Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics1.2450,536info:eu-repo/semantics/openAccess2024-09-03T14:29:55Zoai:repositorio.unesp.br:11449/117637Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:29:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Treatment of osteochondral injuries with platelet gel |
title |
Treatment of osteochondral injuries with platelet gel |
spellingShingle |
Treatment of osteochondral injuries with platelet gel Danieli, Marcus Vinicius [UNESP] Platelet-Rich Plasma Articular Cartilage Injuries Regenerative Medicine |
title_short |
Treatment of osteochondral injuries with platelet gel |
title_full |
Treatment of osteochondral injuries with platelet gel |
title_fullStr |
Treatment of osteochondral injuries with platelet gel |
title_full_unstemmed |
Treatment of osteochondral injuries with platelet gel |
title_sort |
Treatment of osteochondral injuries with platelet gel |
author |
Danieli, Marcus Vinicius [UNESP] |
author_facet |
Danieli, Marcus Vinicius [UNESP] Pereira, Hamilton da Rosa [UNESP] Sa Carneiro, Carlos Augusto de [UNESP] Felisbino, Sergio Luiz [UNESP] Deffune, Elenice [UNESP] |
author_role |
author |
author2 |
Pereira, Hamilton da Rosa [UNESP] Sa Carneiro, Carlos Augusto de [UNESP] Felisbino, Sergio Luiz [UNESP] Deffune, Elenice [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Private Clin & Hosp Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Danieli, Marcus Vinicius [UNESP] Pereira, Hamilton da Rosa [UNESP] Sa Carneiro, Carlos Augusto de [UNESP] Felisbino, Sergio Luiz [UNESP] Deffune, Elenice [UNESP] |
dc.subject.por.fl_str_mv |
Platelet-Rich Plasma Articular Cartilage Injuries Regenerative Medicine |
topic |
Platelet-Rich Plasma Articular Cartilage Injuries Regenerative Medicine |
description |
OBJECTIVES: Treatments for injured articular cartilage have not advanced to the point that efficient regeneration is possible. However, there has been an increase in the use of platelet-rich plasma for the treatment of several orthopedic disorders, including chondral injuries. Our hypothesis is that the treatment of chondral injuries with platelet gel results in higher-quality repair tissue after 180 days compared with chondral injuries not treated with gel.METHODS: A controlled experimental laboratory study was performed on 30 male rabbits to evaluate osteochondral injury repair after treatment with or without platelet gel. Osteochondral injuries were surgically induced in both knees of each rabbit at the medial femoral condyle. The left knee injury was filled with the platelet gel, and the right knee was not treated. Microscopic analysis of both knee samples was performed after 180 days using a histological grading scale.RESULTS: The only histological evaluation criterion that was not significantly different between treatments was metachromasia. The group that was treated with platelet gel exhibited superior results in all other criteria (cell morphology, surface regularity, chondral thickness and repair tissue integration) and in the total score.CONCLUSION: The repair tissue was histologically superior after 180 days in the study group treated with platelet gel compared with the group of untreated injuries. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 2015-03-18T15:56:36Z 2015-03-18T15:56:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.6061/clinics/2014(10)08 Clinics. Sao Paulo: Hospital Clinicas, Univ Sao Paulo, v. 69, n. 10, p. 694-698, 2014. 1807-5932 http://hdl.handle.net/11449/117637 10.6061/clinics/2014(10)08 WOS:000346073000008 WOS000346073000008.pdf 7922265274552064 9646764071339214 |
url |
http://dx.doi.org/10.6061/clinics/2014(10)08 http://hdl.handle.net/11449/117637 |
identifier_str_mv |
Clinics. Sao Paulo: Hospital Clinicas, Univ Sao Paulo, v. 69, n. 10, p. 694-698, 2014. 1807-5932 10.6061/clinics/2014(10)08 WOS:000346073000008 WOS000346073000008.pdf 7922265274552064 9646764071339214 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinics 1.245 0,536 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
694-698 application/pdf |
dc.publisher.none.fl_str_mv |
Hospital Clinicas, Univ Sao Paulo |
publisher.none.fl_str_mv |
Hospital Clinicas, Univ Sao Paulo |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021357404028928 |