The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5935/1518-0557.20200002 http://hdl.handle.net/11449/200703 |
Resumo: | Objective: Patients submitted to oncological fertility preservation with letrozole and gonadotropins seem to present a higher rate of immature oocytes and lower fertilization rates in comparison to infertile patients submitted to IVF cycles with gonadotropins. The aim of this study was to evaluate the influence of letrozole on oocyte morphology in patients with breast cancer submitted to fertility preservation. Methods: Retrospective analysis performed at a pub-lic tertiary hospital in São Paulo, Brazil. The oocytes were retrieved from patients with breast cancer undergoing fertility preservation (n=69), and from infertile women undergoing in vitro fertilization (n=92). We evaluated 750 oocytes obtained from breast cancer patients submitted to ovarian stimulation with letrozole and gonadotropins, and 699 oocytes from patients without breast cancer submitted to ovarian stimulation for in vitro fertilization with go-nadotropins only due to male factor infertility. The mature oocytes retrieved were analyzed for the presence of re-fractile bodies, ooplasm color and regularity, central granulation degree, cortical granules, zona pellucida staining and regularity, perivitelline space, presence of vacuoles or abnormal smooth-surfaced endoplasmic reticle and oocyte retraction. Results: There was a higher incidence of alterations in oocyte morphology in the letrozole group when com-pared to the control group: increased perivitelline space (p=0.007), irregular zona pellucida (p<0.001), refractile bodies (p<0.001), dark ooplasm (p<0.001), granular oo-plasm (p<0.001), irregular ooplasm (p<0.001) and dense central granulation (p<0.001). Conclusion: Letrozole is a risk factor for worse oocyte morphology. However, the clinical impact of ovarian stimulation protocol with combined use of gonadotropins and letrozole for fertility preservation remains unclear in this setting. These data underline the importance of establish-ing the predictive potential of morphological dimorphisms of human oocytes in IVF outcomes. |
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The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservationFertility preservationIn vitro fertilizationOocyte morphologyRandom-start ovarian stimulationObjective: Patients submitted to oncological fertility preservation with letrozole and gonadotropins seem to present a higher rate of immature oocytes and lower fertilization rates in comparison to infertile patients submitted to IVF cycles with gonadotropins. The aim of this study was to evaluate the influence of letrozole on oocyte morphology in patients with breast cancer submitted to fertility preservation. Methods: Retrospective analysis performed at a pub-lic tertiary hospital in São Paulo, Brazil. The oocytes were retrieved from patients with breast cancer undergoing fertility preservation (n=69), and from infertile women undergoing in vitro fertilization (n=92). We evaluated 750 oocytes obtained from breast cancer patients submitted to ovarian stimulation with letrozole and gonadotropins, and 699 oocytes from patients without breast cancer submitted to ovarian stimulation for in vitro fertilization with go-nadotropins only due to male factor infertility. The mature oocytes retrieved were analyzed for the presence of re-fractile bodies, ooplasm color and regularity, central granulation degree, cortical granules, zona pellucida staining and regularity, perivitelline space, presence of vacuoles or abnormal smooth-surfaced endoplasmic reticle and oocyte retraction. Results: There was a higher incidence of alterations in oocyte morphology in the letrozole group when com-pared to the control group: increased perivitelline space (p=0.007), irregular zona pellucida (p<0.001), refractile bodies (p<0.001), dark ooplasm (p<0.001), granular oo-plasm (p<0.001), irregular ooplasm (p<0.001) and dense central granulation (p<0.001). Conclusion: Letrozole is a risk factor for worse oocyte morphology. However, the clinical impact of ovarian stimulation protocol with combined use of gonadotropins and letrozole for fertility preservation remains unclear in this setting. These data underline the importance of establish-ing the predictive potential of morphological dimorphisms of human oocytes in IVF outcomes.Human Reproduction Department Women’s Health Reference Center Pérola Byington HospitalGynecology and Obstetrics Department Botucatu Medical School UNESP-Universidade Estadual de São PauloGynecology and Obstetrics Department Botucatu Medical School UNESP-Universidade Estadual de São PauloPérola Byington HospitalUniversidade Estadual Paulista (Unesp)Bercaire, Ludmila M.N. [UNESP]Cavagna, MarioDonadio, Nilka F.Rocha, Andressa R.Portela, RafaelAlves, Vanessa R.Santos, Thamara B.B.Cavagna, FelipeDzik, ArturGebrim, Luiz H.Nahas, Eliana A.P. [UNESP]2020-12-12T02:13:45Z2020-12-12T02:13:45Z2020-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article257-264http://dx.doi.org/10.5935/1518-0557.20200002Jornal Brasileiro de Reproducao Assistida, v. 24, n. 3, p. 257-264, 2020.1518-05571517-5693http://hdl.handle.net/11449/20070310.5935/1518-0557.202000022-s2.0-85087427159Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJornal Brasileiro de Reproducao Assistidainfo:eu-repo/semantics/openAccess2024-08-16T14:12:37Zoai:repositorio.unesp.br:11449/200703Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation |
title |
The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation |
spellingShingle |
The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation Bercaire, Ludmila M.N. [UNESP] Fertility preservation In vitro fertilization Oocyte morphology Random-start ovarian stimulation |
title_short |
The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation |
title_full |
The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation |
title_fullStr |
The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation |
title_full_unstemmed |
The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation |
title_sort |
The impact of letrozole administration on oocyte morphology in breast cancer patients undergoing fertility preservation |
author |
Bercaire, Ludmila M.N. [UNESP] |
author_facet |
Bercaire, Ludmila M.N. [UNESP] Cavagna, Mario Donadio, Nilka F. Rocha, Andressa R. Portela, Rafael Alves, Vanessa R. Santos, Thamara B.B. Cavagna, Felipe Dzik, Artur Gebrim, Luiz H. Nahas, Eliana A.P. [UNESP] |
author_role |
author |
author2 |
Cavagna, Mario Donadio, Nilka F. Rocha, Andressa R. Portela, Rafael Alves, Vanessa R. Santos, Thamara B.B. Cavagna, Felipe Dzik, Artur Gebrim, Luiz H. Nahas, Eliana A.P. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Pérola Byington Hospital Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bercaire, Ludmila M.N. [UNESP] Cavagna, Mario Donadio, Nilka F. Rocha, Andressa R. Portela, Rafael Alves, Vanessa R. Santos, Thamara B.B. Cavagna, Felipe Dzik, Artur Gebrim, Luiz H. Nahas, Eliana A.P. [UNESP] |
dc.subject.por.fl_str_mv |
Fertility preservation In vitro fertilization Oocyte morphology Random-start ovarian stimulation |
topic |
Fertility preservation In vitro fertilization Oocyte morphology Random-start ovarian stimulation |
description |
Objective: Patients submitted to oncological fertility preservation with letrozole and gonadotropins seem to present a higher rate of immature oocytes and lower fertilization rates in comparison to infertile patients submitted to IVF cycles with gonadotropins. The aim of this study was to evaluate the influence of letrozole on oocyte morphology in patients with breast cancer submitted to fertility preservation. Methods: Retrospective analysis performed at a pub-lic tertiary hospital in São Paulo, Brazil. The oocytes were retrieved from patients with breast cancer undergoing fertility preservation (n=69), and from infertile women undergoing in vitro fertilization (n=92). We evaluated 750 oocytes obtained from breast cancer patients submitted to ovarian stimulation with letrozole and gonadotropins, and 699 oocytes from patients without breast cancer submitted to ovarian stimulation for in vitro fertilization with go-nadotropins only due to male factor infertility. The mature oocytes retrieved were analyzed for the presence of re-fractile bodies, ooplasm color and regularity, central granulation degree, cortical granules, zona pellucida staining and regularity, perivitelline space, presence of vacuoles or abnormal smooth-surfaced endoplasmic reticle and oocyte retraction. Results: There was a higher incidence of alterations in oocyte morphology in the letrozole group when com-pared to the control group: increased perivitelline space (p=0.007), irregular zona pellucida (p<0.001), refractile bodies (p<0.001), dark ooplasm (p<0.001), granular oo-plasm (p<0.001), irregular ooplasm (p<0.001) and dense central granulation (p<0.001). Conclusion: Letrozole is a risk factor for worse oocyte morphology. However, the clinical impact of ovarian stimulation protocol with combined use of gonadotropins and letrozole for fertility preservation remains unclear in this setting. These data underline the importance of establish-ing the predictive potential of morphological dimorphisms of human oocytes in IVF outcomes. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:13:45Z 2020-12-12T02:13:45Z 2020-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5935/1518-0557.20200002 Jornal Brasileiro de Reproducao Assistida, v. 24, n. 3, p. 257-264, 2020. 1518-0557 1517-5693 http://hdl.handle.net/11449/200703 10.5935/1518-0557.20200002 2-s2.0-85087427159 |
url |
http://dx.doi.org/10.5935/1518-0557.20200002 http://hdl.handle.net/11449/200703 |
identifier_str_mv |
Jornal Brasileiro de Reproducao Assistida, v. 24, n. 3, p. 257-264, 2020. 1518-0557 1517-5693 10.5935/1518-0557.20200002 2-s2.0-85087427159 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Jornal Brasileiro de Reproducao Assistida |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
257-264 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128181973024768 |