Bats respond to simulated bacterial infection during the active phase by reducing food intake
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/jez.2399 http://hdl.handle.net/11449/195524 |
Resumo: | Sickness triggers a series of behavioral and physiological processes collectively known as acute phase response (APR). Bats are known as reservoirs of a broad variety of pathogens and the physiological changes resulting from APR activation have been tested predominantly during the resting phase (daytime) in several species exposed to lipopolysaccharide (LPS). In contrast, behavioral consequences of sickness for bats and other wild mammals have received less attention. We examined the physiological and behavioral consequences of APR activation in a fruit-eating bat (Carollia perspicillata) challenged with LPS during the active phase (nighttime). We measured changes in food intake, body mass, body temperature, total white blood cell counts, and the neutrophil/lymphocyte ratio (N/L). No fever and leukocytosis were observed in bats injected with LPS, but food intake decreased, bats lost body mass and their N/L ratio increased. The effect of LPS on daily energy balance is remarkable and, along with the increase in N/L ratio, it is assumed to be beneficial to fight disease. On the basis of our findings and those with other bats, it is probable that the physiological and behavioral components of the immune response to LPS follow circadian rhythms, but a formal test of this hypothesis is warranted. |
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Bats respond to simulated bacterial infection during the active phase by reducing food intakebatCarollia perspicillatafeverimmune responseleukocytosisLPSsickness behaviorSickness triggers a series of behavioral and physiological processes collectively known as acute phase response (APR). Bats are known as reservoirs of a broad variety of pathogens and the physiological changes resulting from APR activation have been tested predominantly during the resting phase (daytime) in several species exposed to lipopolysaccharide (LPS). In contrast, behavioral consequences of sickness for bats and other wild mammals have received less attention. We examined the physiological and behavioral consequences of APR activation in a fruit-eating bat (Carollia perspicillata) challenged with LPS during the active phase (nighttime). We measured changes in food intake, body mass, body temperature, total white blood cell counts, and the neutrophil/lymphocyte ratio (N/L). No fever and leukocytosis were observed in bats injected with LPS, but food intake decreased, bats lost body mass and their N/L ratio increased. The effect of LPS on daily energy balance is remarkable and, along with the increase in N/L ratio, it is assumed to be beneficial to fight disease. On the basis of our findings and those with other bats, it is probable that the physiological and behavioral components of the immune response to LPS follow circadian rhythms, but a formal test of this hypothesis is warranted.Direccion General de Asuntos del Personal Academico, Universidad Nacional Autonoma de MexicoConsejo Nacional de Ciencia y TecnologiaConselho Nacional de Pesquisa e Desenvolvimento TecnologicoFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, Dept Biodiversidade, Inst Biociencias, Rio Claro, SP, BrazilUniv Nacl Autonoma Mexico, Inst Biol, Estn Biol Chamela, San Patricio, Jalisco, MexicoUniv Estadual Paulista, Dept Biodiversidade, Inst Biociencias, Rio Claro, SP, BrazilDireccion General de Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico: 814-2018Consejo Nacional de Ciencia y Tecnologia: 490586/2013-9Conselho Nacional de Pesquisa e Desenvolvimento Tecnologico: 43486Conselho Nacional de Pesquisa e Desenvolvimento Tecnologico: 490586/20139FAPESP: 2014/17607-4FAPESP: 2017-17607-6Wiley-BlackwellUniversidade Estadual Paulista (Unesp)Univ Nacl Autonoma MexicoMelhado, Gabriel [UNESP]Herrera M., L. GerardoCruz-Neto, Ariovaldo P. da [UNESP]2020-12-10T17:37:32Z2020-12-10T17:37:32Z2020-07-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7http://dx.doi.org/10.1002/jez.2399Journal Of Experimental Zoology Part A-ecological And Integrative Physiology. Hoboken: Wiley, 7 p., 2020.2471-5638http://hdl.handle.net/11449/19552410.1002/jez.2399WOS:000550434800001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Experimental Zoology Part A-ecological And Integrative Physiologyinfo:eu-repo/semantics/openAccess2021-10-23T09:20:15Zoai:repositorio.unesp.br:11449/195524Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T09:20:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bats respond to simulated bacterial infection during the active phase by reducing food intake |
title |
Bats respond to simulated bacterial infection during the active phase by reducing food intake |
spellingShingle |
Bats respond to simulated bacterial infection during the active phase by reducing food intake Melhado, Gabriel [UNESP] bat Carollia perspicillata fever immune response leukocytosis LPS sickness behavior |
title_short |
Bats respond to simulated bacterial infection during the active phase by reducing food intake |
title_full |
Bats respond to simulated bacterial infection during the active phase by reducing food intake |
title_fullStr |
Bats respond to simulated bacterial infection during the active phase by reducing food intake |
title_full_unstemmed |
Bats respond to simulated bacterial infection during the active phase by reducing food intake |
title_sort |
Bats respond to simulated bacterial infection during the active phase by reducing food intake |
author |
Melhado, Gabriel [UNESP] |
author_facet |
Melhado, Gabriel [UNESP] Herrera M., L. Gerardo Cruz-Neto, Ariovaldo P. da [UNESP] |
author_role |
author |
author2 |
Herrera M., L. Gerardo Cruz-Neto, Ariovaldo P. da [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Nacl Autonoma Mexico |
dc.contributor.author.fl_str_mv |
Melhado, Gabriel [UNESP] Herrera M., L. Gerardo Cruz-Neto, Ariovaldo P. da [UNESP] |
dc.subject.por.fl_str_mv |
bat Carollia perspicillata fever immune response leukocytosis LPS sickness behavior |
topic |
bat Carollia perspicillata fever immune response leukocytosis LPS sickness behavior |
description |
Sickness triggers a series of behavioral and physiological processes collectively known as acute phase response (APR). Bats are known as reservoirs of a broad variety of pathogens and the physiological changes resulting from APR activation have been tested predominantly during the resting phase (daytime) in several species exposed to lipopolysaccharide (LPS). In contrast, behavioral consequences of sickness for bats and other wild mammals have received less attention. We examined the physiological and behavioral consequences of APR activation in a fruit-eating bat (Carollia perspicillata) challenged with LPS during the active phase (nighttime). We measured changes in food intake, body mass, body temperature, total white blood cell counts, and the neutrophil/lymphocyte ratio (N/L). No fever and leukocytosis were observed in bats injected with LPS, but food intake decreased, bats lost body mass and their N/L ratio increased. The effect of LPS on daily energy balance is remarkable and, along with the increase in N/L ratio, it is assumed to be beneficial to fight disease. On the basis of our findings and those with other bats, it is probable that the physiological and behavioral components of the immune response to LPS follow circadian rhythms, but a formal test of this hypothesis is warranted. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-10T17:37:32Z 2020-12-10T17:37:32Z 2020-07-21 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/jez.2399 Journal Of Experimental Zoology Part A-ecological And Integrative Physiology. Hoboken: Wiley, 7 p., 2020. 2471-5638 http://hdl.handle.net/11449/195524 10.1002/jez.2399 WOS:000550434800001 |
url |
http://dx.doi.org/10.1002/jez.2399 http://hdl.handle.net/11449/195524 |
identifier_str_mv |
Journal Of Experimental Zoology Part A-ecological And Integrative Physiology. Hoboken: Wiley, 7 p., 2020. 2471-5638 10.1002/jez.2399 WOS:000550434800001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Experimental Zoology Part A-ecological And Integrative Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046016220397568 |