Ivabradine: Just another New Pharmacological Option for Heart Rate Control?
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4172/2155-9880.S4-001 http://hdl.handle.net/11449/115480 |
Resumo: | Ivabradine (IVB) is a heart rate lowering agent that acts via selective inhibition of the pacemaker funny current in sinoatrial nodal P cells, thus, reducing heart rate at rest and during exercise with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. IVB exerts no effect on external respiratory function parameters and it may also play a role in patients with concurrent chronic obstructive pulmonary disease. This property constitutes an important advantage over β-blockers. IVB acts by reducing the heart rate in a mechanism different from β-blockers, calcium channel blockers or late sodium channel blockers, three commonly prescribed antianginal drugs. As clinical trials have shown, it is remarkably well-tolerated and offers an alternative for patients who cannot take β-blockers. The combination of IVB and atenolol at commonly used doses in patients with chronic stable angina produced additional efficacy with no untoward effect on safety or tolerability. Additionally, side effects are rare and largely limited to a luminous phenomenon or phosphenes. This sensation is thought to be due to a block of Ih in the retina, a current very similar to cardiac If channels. IVB is contraindicated in patients with sick sinus syndrome or sinus node dysfunction and in patients taking hepatic inhibitors of Cytochrome P450 family 3, subfamily A, polypeptide 4 (abbreviated CYP3A4), with exception of omeprazole or lansoprazole. This review briefly summarizes the main studies regarding this drug. |
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Ivabradine: Just another New Pharmacological Option for Heart Rate Control?Ivabradine (IVB) is a heart rate lowering agent that acts via selective inhibition of the pacemaker funny current in sinoatrial nodal P cells, thus, reducing heart rate at rest and during exercise with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. IVB exerts no effect on external respiratory function parameters and it may also play a role in patients with concurrent chronic obstructive pulmonary disease. This property constitutes an important advantage over β-blockers. IVB acts by reducing the heart rate in a mechanism different from β-blockers, calcium channel blockers or late sodium channel blockers, three commonly prescribed antianginal drugs. As clinical trials have shown, it is remarkably well-tolerated and offers an alternative for patients who cannot take β-blockers. The combination of IVB and atenolol at commonly used doses in patients with chronic stable angina produced additional efficacy with no untoward effect on safety or tolerability. Additionally, side effects are rare and largely limited to a luminous phenomenon or phosphenes. This sensation is thought to be due to a block of Ih in the retina, a current very similar to cardiac If channels. IVB is contraindicated in patients with sick sinus syndrome or sinus node dysfunction and in patients taking hepatic inhibitors of Cytochrome P450 family 3, subfamily A, polypeptide 4 (abbreviated CYP3A4), with exception of omeprazole or lansoprazole. This review briefly summarizes the main studies regarding this drug.Departamento de Fisioterapia, Faculdade de Ciência e Tecnologia, UNESP, Presidente Prudente, SP, BrasilFaculdade de Medicina do ABC (FMABC)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Faculdade Federal do Ceará (UFC)Perez Riera, Andres RicardoAbreu, Luiz Carlos deValenti, Vitor EngráciaFonseca, Fernando A. L.Ferreira, MarceloVanderlei, Luiz Carlos Marques [UNESP]Ferreira Filho, CelsoMonteiro, Carlos B. de MelloRolim Neto, Modesto LeiteRodrigues, Luciano M. R.Ferreira, Celso2015-02-24T13:58:07Z2015-02-24T13:58:07Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1application/pdfhttp://dx.doi.org/10.4172/2155-9880.S4-001Journal of Clinical & Experimental Cardiology, v. 04, n. 4, p. 1, 2011.2155-9880http://hdl.handle.net/11449/11548010.4172/2155-9880.S4-001ISSN21559880-2011-04-S4-01.pdf67969706914328508456421836597174289175230885988758605251351069951788268008188276Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Clinical & Experimental Cardiology0,168info:eu-repo/semantics/openAccess2023-12-12T06:22:02Zoai:repositorio.unesp.br:11449/115480Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-12T06:22:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ivabradine: Just another New Pharmacological Option for Heart Rate Control? |
title |
Ivabradine: Just another New Pharmacological Option for Heart Rate Control? |
spellingShingle |
Ivabradine: Just another New Pharmacological Option for Heart Rate Control? Perez Riera, Andres Ricardo |
title_short |
Ivabradine: Just another New Pharmacological Option for Heart Rate Control? |
title_full |
Ivabradine: Just another New Pharmacological Option for Heart Rate Control? |
title_fullStr |
Ivabradine: Just another New Pharmacological Option for Heart Rate Control? |
title_full_unstemmed |
Ivabradine: Just another New Pharmacological Option for Heart Rate Control? |
title_sort |
Ivabradine: Just another New Pharmacological Option for Heart Rate Control? |
author |
Perez Riera, Andres Ricardo |
author_facet |
Perez Riera, Andres Ricardo Abreu, Luiz Carlos de Valenti, Vitor Engrácia Fonseca, Fernando A. L. Ferreira, Marcelo Vanderlei, Luiz Carlos Marques [UNESP] Ferreira Filho, Celso Monteiro, Carlos B. de Mello Rolim Neto, Modesto Leite Rodrigues, Luciano M. R. Ferreira, Celso |
author_role |
author |
author2 |
Abreu, Luiz Carlos de Valenti, Vitor Engrácia Fonseca, Fernando A. L. Ferreira, Marcelo Vanderlei, Luiz Carlos Marques [UNESP] Ferreira Filho, Celso Monteiro, Carlos B. de Mello Rolim Neto, Modesto Leite Rodrigues, Luciano M. R. Ferreira, Celso |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina do ABC (FMABC) Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Faculdade Federal do Ceará (UFC) |
dc.contributor.author.fl_str_mv |
Perez Riera, Andres Ricardo Abreu, Luiz Carlos de Valenti, Vitor Engrácia Fonseca, Fernando A. L. Ferreira, Marcelo Vanderlei, Luiz Carlos Marques [UNESP] Ferreira Filho, Celso Monteiro, Carlos B. de Mello Rolim Neto, Modesto Leite Rodrigues, Luciano M. R. Ferreira, Celso |
description |
Ivabradine (IVB) is a heart rate lowering agent that acts via selective inhibition of the pacemaker funny current in sinoatrial nodal P cells, thus, reducing heart rate at rest and during exercise with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. IVB exerts no effect on external respiratory function parameters and it may also play a role in patients with concurrent chronic obstructive pulmonary disease. This property constitutes an important advantage over β-blockers. IVB acts by reducing the heart rate in a mechanism different from β-blockers, calcium channel blockers or late sodium channel blockers, three commonly prescribed antianginal drugs. As clinical trials have shown, it is remarkably well-tolerated and offers an alternative for patients who cannot take β-blockers. The combination of IVB and atenolol at commonly used doses in patients with chronic stable angina produced additional efficacy with no untoward effect on safety or tolerability. Additionally, side effects are rare and largely limited to a luminous phenomenon or phosphenes. This sensation is thought to be due to a block of Ih in the retina, a current very similar to cardiac If channels. IVB is contraindicated in patients with sick sinus syndrome or sinus node dysfunction and in patients taking hepatic inhibitors of Cytochrome P450 family 3, subfamily A, polypeptide 4 (abbreviated CYP3A4), with exception of omeprazole or lansoprazole. This review briefly summarizes the main studies regarding this drug. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2015-02-24T13:58:07Z 2015-02-24T13:58:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4172/2155-9880.S4-001 Journal of Clinical & Experimental Cardiology, v. 04, n. 4, p. 1, 2011. 2155-9880 http://hdl.handle.net/11449/115480 10.4172/2155-9880.S4-001 ISSN21559880-2011-04-S4-01.pdf 6796970691432850 8456421836597174 2891752308859887 5860525135106995 1788268008188276 |
url |
http://dx.doi.org/10.4172/2155-9880.S4-001 http://hdl.handle.net/11449/115480 |
identifier_str_mv |
Journal of Clinical & Experimental Cardiology, v. 04, n. 4, p. 1, 2011. 2155-9880 10.4172/2155-9880.S4-001 ISSN21559880-2011-04-S4-01.pdf 6796970691432850 8456421836597174 2891752308859887 5860525135106995 1788268008188276 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Clinical & Experimental Cardiology 0,168 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965262346190848 |