Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology

• Autor(a) principal: Andrade, Laise R. de
• Data de Publicação: 2020
• Outros Autores: Tedesco, Antonio C., Primo, Fernando L. [UNESP], Farias, Gabriel R., Silva, Jaqueline R. da, Longo, Joao P. F., Almeida, Marcos C. de, Souza, Paulo E. N. de, Azevedo, Ricardo B. de, Pinheiro, Willie O., Lacava, Zulmira G. M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.2217/nnm-2019-0458; http://hdl.handle.net/11449/195430
• topic: 4T1 cells; 5-aminolevulinic acid; breast cancer; photodynamic therapy; polymeric nanoemulsion

Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.