Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology

Detalhes bibliográficos
Autor(a) principal: Andrade, Laise R. de
Data de Publicação: 2020
Outros Autores: Tedesco, Antonio C., Primo, Fernando L. [UNESP], Farias, Gabriel R., Silva, Jaqueline R. da, Longo, Joao P. F., Almeida, Marcos C. de, Souza, Paulo E. N. de, Azevedo, Ricardo B. de, Pinheiro, Willie O., Lacava, Zulmira G. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2217/nnm-2019-0458
http://hdl.handle.net/11449/195430
Resumo: Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.
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spelling Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology4T1 cells5-aminolevulinic acidbreast cancerphotodynamic therapypolymeric nanoemulsionAim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Foundation to Support Research in the Federal District (FAPDF)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)National Institute of Science and Technology in Nanobiotechnology (INCTNanobiotecnologia)Center for Nanoscience and Nanobiotechnology of the University of Bras'ilia (CNANO-UnB)Dean of Research and Post-Graduation of the University of Brasilia (DPP-UnB)Univ Brasilia, Inst Biol Sci, Dept Genet & Morphol, BR-70910900 Brasilia, DF, BrazilUniv Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Ctr Nanotechnol & Tissue Engn Photobiol, Dept Chem, BR-14010100 Ribeirao Preto, BrazilUniv Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Photomed Res Grp, BR-14010100 Ribeirao Preto, BrazilSao Paulo State Univ, Sch Pharmaceut Sci, Dept Engn Bioproc & Biotechnol, BR-14800903 Araraquara, SP, BrazilUniv Brasilia, Inst Phys, Lab Electron Paramagnet Resonance, BR-70919970 Brasilia, DF, BrazilUniv Brasilia, Fac Ceilandia, Postgrad Program Sci & Technol Hlth, BR-72220275 Brasilia, DF, BrazilSao Paulo State Univ, Sch Pharmaceut Sci, Dept Engn Bioproc & Biotechnol, BR-14800903 Araraquara, SP, BrazilFAPESP: 2013/50181-1Future Medicine LtdUniversidade de Brasília (UnB)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Andrade, Laise R. deTedesco, Antonio C.Primo, Fernando L. [UNESP]Farias, Gabriel R.Silva, Jaqueline R. daLongo, Joao P. F.Almeida, Marcos C. deSouza, Paulo E. N. deAzevedo, Ricardo B. dePinheiro, Willie O.Lacava, Zulmira G. M.2020-12-10T17:34:22Z2020-12-10T17:34:22Z2020-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1019-1036http://dx.doi.org/10.2217/nnm-2019-0458Nanomedicine. London: Future Medicine Ltd, v. 15, n. 10, p. 1019-1036, 2020.1743-5889http://hdl.handle.net/11449/19543010.2217/nnm-2019-0458WOS:000539101300006Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNanomedicineinfo:eu-repo/semantics/openAccess2021-10-23T08:05:17Zoai:repositorio.unesp.br:11449/195430Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:26:19.303524Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
title Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
spellingShingle Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
Andrade, Laise R. de
4T1 cells
5-aminolevulinic acid
breast cancer
photodynamic therapy
polymeric nanoemulsion
title_short Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
title_full Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
title_fullStr Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
title_full_unstemmed Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
title_sort Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
author Andrade, Laise R. de
author_facet Andrade, Laise R. de
Tedesco, Antonio C.
Primo, Fernando L. [UNESP]
Farias, Gabriel R.
Silva, Jaqueline R. da
Longo, Joao P. F.
Almeida, Marcos C. de
Souza, Paulo E. N. de
Azevedo, Ricardo B. de
Pinheiro, Willie O.
Lacava, Zulmira G. M.
author_role author
author2 Tedesco, Antonio C.
Primo, Fernando L. [UNESP]
Farias, Gabriel R.
Silva, Jaqueline R. da
Longo, Joao P. F.
Almeida, Marcos C. de
Souza, Paulo E. N. de
Azevedo, Ricardo B. de
Pinheiro, Willie O.
Lacava, Zulmira G. M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Brasília (UnB)
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Andrade, Laise R. de
Tedesco, Antonio C.
Primo, Fernando L. [UNESP]
Farias, Gabriel R.
Silva, Jaqueline R. da
Longo, Joao P. F.
Almeida, Marcos C. de
Souza, Paulo E. N. de
Azevedo, Ricardo B. de
Pinheiro, Willie O.
Lacava, Zulmira G. M.
dc.subject.por.fl_str_mv 4T1 cells
5-aminolevulinic acid
breast cancer
photodynamic therapy
polymeric nanoemulsion
topic 4T1 cells
5-aminolevulinic acid
breast cancer
photodynamic therapy
polymeric nanoemulsion
description Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-10T17:34:22Z
2020-12-10T17:34:22Z
2020-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2217/nnm-2019-0458
Nanomedicine. London: Future Medicine Ltd, v. 15, n. 10, p. 1019-1036, 2020.
1743-5889
http://hdl.handle.net/11449/195430
10.2217/nnm-2019-0458
WOS:000539101300006
url http://dx.doi.org/10.2217/nnm-2019-0458
http://hdl.handle.net/11449/195430
identifier_str_mv Nanomedicine. London: Future Medicine Ltd, v. 15, n. 10, p. 1019-1036, 2020.
1743-5889
10.2217/nnm-2019-0458
WOS:000539101300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nanomedicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1019-1036
dc.publisher.none.fl_str_mv Future Medicine Ltd
publisher.none.fl_str_mv Future Medicine Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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