Chemosensory control by commissural nucleus of the solitary tract in rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.resp.2011.08.010 http://hdl.handle.net/11449/16347 |
Resumo: | The commissural nucleus of the solitary tract (commNTS) is a main area that receives afferent signals involved in the cardiovascular and respiratory control like those related to chemoreceptor activation. however, the importance of the commNTS for the cardiorespiratory responses to chemoreceptor activation is still controversial. In the present study, we investigated the cardiorespiratory responses to hypoxia or hypercapnia in anesthetized and conscious rats treated with injections of the GABA-A agonist muscimol into the caudal portion of the commNTS. Male :Holtzman rats (280-300g) were used. In conscious rats that had a stainless steel cannula previously implanted into the commNTS, the injection of muscimol (2 mM) into the commNTS reduced the pressor response (16 +/- 2 mmHg, vs. saline: 36 +/- 3 mmHg) and the increase in ventilation (250 +/- 17 ml/min/kg, vs. saline: 641 +/- 28 ml/min/kg) produced by hypoxia (8-10% O(2)). In urethane anesthetized rats, the injection of muscimol into the commNTS eliminated the pressor response (5 +/- 2 mmHg, vs. saline: 26 +/- 5 mmHg) and the increase in phrenic nerve discharge (PND) (20 +/- 6%, vs. saline: 149 +/- 15%) and reduced the increase in splanchnic sympathetic nerve discharge (sSND) (93 +/- 15%, vs. saline: 283 +/- 19% of baseline) produced by hypoxia. However, muscimol injected into the commNTS did not change hypercapnia (8-10% CO(2)) induced pressor response or the increase in the sSND or PND in urethane anesthetized rats or the increase in ventilation in conscious rats. The present results suggest that the cardiorespiratory responses to hypoxia are strongly dependent on the caudal portion of the commNTS, however, this area is not involved in the responses to hypercapnia. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved. |
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Chemosensory control by commissural nucleus of the solitary tract in ratsCentral and peripheral chemoreflexBreathingSympathetic activityNTSHypoxiaThe commissural nucleus of the solitary tract (commNTS) is a main area that receives afferent signals involved in the cardiovascular and respiratory control like those related to chemoreceptor activation. however, the importance of the commNTS for the cardiorespiratory responses to chemoreceptor activation is still controversial. In the present study, we investigated the cardiorespiratory responses to hypoxia or hypercapnia in anesthetized and conscious rats treated with injections of the GABA-A agonist muscimol into the caudal portion of the commNTS. Male :Holtzman rats (280-300g) were used. In conscious rats that had a stainless steel cannula previously implanted into the commNTS, the injection of muscimol (2 mM) into the commNTS reduced the pressor response (16 +/- 2 mmHg, vs. saline: 36 +/- 3 mmHg) and the increase in ventilation (250 +/- 17 ml/min/kg, vs. saline: 641 +/- 28 ml/min/kg) produced by hypoxia (8-10% O(2)). In urethane anesthetized rats, the injection of muscimol into the commNTS eliminated the pressor response (5 +/- 2 mmHg, vs. saline: 26 +/- 5 mmHg) and the increase in phrenic nerve discharge (PND) (20 +/- 6%, vs. saline: 149 +/- 15%) and reduced the increase in splanchnic sympathetic nerve discharge (sSND) (93 +/- 15%, vs. saline: 283 +/- 19% of baseline) produced by hypoxia. However, muscimol injected into the commNTS did not change hypercapnia (8-10% CO(2)) induced pressor response or the increase in the sSND or PND in urethane anesthetized rats or the increase in ventilation in conscious rats. The present results suggest that the cardiorespiratory responses to hypoxia are strongly dependent on the caudal portion of the commNTS, however, this area is not involved in the responses to hypercapnia. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ São Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 São Paulo, BrazilSão Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, BrazilUniv São Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 São Paulo, BrazilSão Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, BrazilFAPESP: 06/60174-9FAPESP: 10/09776-3Elsevier B.V.Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Favero, Michele T. [UNESP]Takakura, Ana C.de Paula, Patricia M. [UNESP]Colombari, Eduardo [UNESP]Menani, José Vanderlei [UNESP]Moreira, Thiago S.2014-05-20T13:46:16Z2014-05-20T13:46:16Z2011-12-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article227-234application/pdfhttp://dx.doi.org/10.1016/j.resp.2011.08.010Respiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 179, n. 2-3, p. 227-234, 2011.1569-9048http://hdl.handle.net/11449/1634710.1016/j.resp.2011.08.010WOS:000297903500022WOS000297903500022.pdf45444500924274261023597870118105Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRespiratory Physiology & Neurobiology1.7920,682info:eu-repo/semantics/openAccess2023-10-19T06:10:38Zoai:repositorio.unesp.br:11449/16347Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:22:50.279590Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Chemosensory control by commissural nucleus of the solitary tract in rats |
title |
Chemosensory control by commissural nucleus of the solitary tract in rats |
spellingShingle |
Chemosensory control by commissural nucleus of the solitary tract in rats Favero, Michele T. [UNESP] Central and peripheral chemoreflex Breathing Sympathetic activity NTS Hypoxia |
title_short |
Chemosensory control by commissural nucleus of the solitary tract in rats |
title_full |
Chemosensory control by commissural nucleus of the solitary tract in rats |
title_fullStr |
Chemosensory control by commissural nucleus of the solitary tract in rats |
title_full_unstemmed |
Chemosensory control by commissural nucleus of the solitary tract in rats |
title_sort |
Chemosensory control by commissural nucleus of the solitary tract in rats |
author |
Favero, Michele T. [UNESP] |
author_facet |
Favero, Michele T. [UNESP] Takakura, Ana C. de Paula, Patricia M. [UNESP] Colombari, Eduardo [UNESP] Menani, José Vanderlei [UNESP] Moreira, Thiago S. |
author_role |
author |
author2 |
Takakura, Ana C. de Paula, Patricia M. [UNESP] Colombari, Eduardo [UNESP] Menani, José Vanderlei [UNESP] Moreira, Thiago S. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Favero, Michele T. [UNESP] Takakura, Ana C. de Paula, Patricia M. [UNESP] Colombari, Eduardo [UNESP] Menani, José Vanderlei [UNESP] Moreira, Thiago S. |
dc.subject.por.fl_str_mv |
Central and peripheral chemoreflex Breathing Sympathetic activity NTS Hypoxia |
topic |
Central and peripheral chemoreflex Breathing Sympathetic activity NTS Hypoxia |
description |
The commissural nucleus of the solitary tract (commNTS) is a main area that receives afferent signals involved in the cardiovascular and respiratory control like those related to chemoreceptor activation. however, the importance of the commNTS for the cardiorespiratory responses to chemoreceptor activation is still controversial. In the present study, we investigated the cardiorespiratory responses to hypoxia or hypercapnia in anesthetized and conscious rats treated with injections of the GABA-A agonist muscimol into the caudal portion of the commNTS. Male :Holtzman rats (280-300g) were used. In conscious rats that had a stainless steel cannula previously implanted into the commNTS, the injection of muscimol (2 mM) into the commNTS reduced the pressor response (16 +/- 2 mmHg, vs. saline: 36 +/- 3 mmHg) and the increase in ventilation (250 +/- 17 ml/min/kg, vs. saline: 641 +/- 28 ml/min/kg) produced by hypoxia (8-10% O(2)). In urethane anesthetized rats, the injection of muscimol into the commNTS eliminated the pressor response (5 +/- 2 mmHg, vs. saline: 26 +/- 5 mmHg) and the increase in phrenic nerve discharge (PND) (20 +/- 6%, vs. saline: 149 +/- 15%) and reduced the increase in splanchnic sympathetic nerve discharge (sSND) (93 +/- 15%, vs. saline: 283 +/- 19% of baseline) produced by hypoxia. However, muscimol injected into the commNTS did not change hypercapnia (8-10% CO(2)) induced pressor response or the increase in the sSND or PND in urethane anesthetized rats or the increase in ventilation in conscious rats. The present results suggest that the cardiorespiratory responses to hypoxia are strongly dependent on the caudal portion of the commNTS, however, this area is not involved in the responses to hypercapnia. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-15 2014-05-20T13:46:16Z 2014-05-20T13:46:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.resp.2011.08.010 Respiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 179, n. 2-3, p. 227-234, 2011. 1569-9048 http://hdl.handle.net/11449/16347 10.1016/j.resp.2011.08.010 WOS:000297903500022 WOS000297903500022.pdf 4544450092427426 1023597870118105 |
url |
http://dx.doi.org/10.1016/j.resp.2011.08.010 http://hdl.handle.net/11449/16347 |
identifier_str_mv |
Respiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 179, n. 2-3, p. 227-234, 2011. 1569-9048 10.1016/j.resp.2011.08.010 WOS:000297903500022 WOS000297903500022.pdf 4544450092427426 1023597870118105 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Respiratory Physiology & Neurobiology 1.792 0,682 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
227-234 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128506116177920 |