Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.biopha.2018.12.091 http://hdl.handle.net/11449/186640 |
Resumo: | In Brazilian folk medicine, copaiba oleoresin is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Considering the relationship between inflammatory processes and carcinogenesis, this paper reports on the Copaifera reticulata Ducke oleoresin (CRO) chemopreventive potential in the colon carcinogenesis model in rats. To understand the mechanisms involved in this effect, the anti-inflammatory activity of CRO and its major chemical constituent, the diterpene ent-polyalthic acid (PA), were evaluated on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in mouse macrophages. For the chemoprevention assessment, the effect of CRO administered by gavage was investigated on DNA damage, preneoplastic lesions and mitotic frequencies induced by the 1,2-dimethylhydrazine (DMH; intraperitoneal injection) carcinogen by comet, aberrant crypt focus (ACF) and long-term assays, respectively. CRO reduced DNA damage (average 31.5%) and pre-neoplastic lesions (average 64.5%) induced by DMH, which revealed that CRO has antigenotoxic and anticarcinogenic effects. In the long-term assay, treatment with CRO significantly decreased mitoses in the tumor tissue, which suggested that CRO influenced carcinogenesis progression. PA reduced NO levels induced by lipopolysaccharides in macrophages. However, this diterpene showed no effect on PGE2. Taken together, our results suggest that PA exerts anti-inflammatory action via the NO pathway. The CRO chemopreventive effect may be partly due to the anti-inflammatory property of its major chemical constituent, PA. Our findings indicate that CRO is a promising agent to suppress colon carcinogenesis. |
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Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesisCopaifera reticulata Duckeent-polyalthic acidAntigenotoxicityAnticarcinogenesisAnti-inflammatory activityIn Brazilian folk medicine, copaiba oleoresin is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Considering the relationship between inflammatory processes and carcinogenesis, this paper reports on the Copaifera reticulata Ducke oleoresin (CRO) chemopreventive potential in the colon carcinogenesis model in rats. To understand the mechanisms involved in this effect, the anti-inflammatory activity of CRO and its major chemical constituent, the diterpene ent-polyalthic acid (PA), were evaluated on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in mouse macrophages. For the chemoprevention assessment, the effect of CRO administered by gavage was investigated on DNA damage, preneoplastic lesions and mitotic frequencies induced by the 1,2-dimethylhydrazine (DMH; intraperitoneal injection) carcinogen by comet, aberrant crypt focus (ACF) and long-term assays, respectively. CRO reduced DNA damage (average 31.5%) and pre-neoplastic lesions (average 64.5%) induced by DMH, which revealed that CRO has antigenotoxic and anticarcinogenic effects. In the long-term assay, treatment with CRO significantly decreased mitoses in the tumor tissue, which suggested that CRO influenced carcinogenesis progression. PA reduced NO levels induced by lipopolysaccharides in macrophages. However, this diterpene showed no effect on PGE2. Taken together, our results suggest that PA exerts anti-inflammatory action via the NO pathway. The CRO chemopreventive effect may be partly due to the anti-inflammatory property of its major chemical constituent, PA. Our findings indicate that CRO is a promising agent to suppress colon carcinogenesis.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Paulo, Sch Pharmaceut Sci, BR-14040903 Ribeirao Preto, SP, BrazilUniv Franca, Ave Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Rodovia Araraquara Jau Km 1, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Rodovia Araraquara Jau Km 1, BR-14801902 Araraquara, SP, BrazilFAPESP: 2011/13630-7FAPESP: 2013/19488-3Elsevier B.V.Universidade de São Paulo (USP)Univ FrancaUniversidade Estadual Paulista (Unesp)Senedese, Juliana MarquesRinaldi-Neto, FranciscoFurtado, Ricardo AndradeNicollela, Heloiza DinizRibeiro de Souza, Larissa DanielaRibeiro, Arthur BarcelosFerreira, Lucas Souza [UNESP]Magalhaes, Georgia ModeCarlos, Iracilda Zeppone [UNESP]Mangabeira da Silva, Jonas JoaquimTavares, Denise CrispimBastos, Jairo Kenupp2019-10-05T13:16:58Z2019-10-05T13:16:58Z2019-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article331-337http://dx.doi.org/10.1016/j.biopha.2018.12.091Biomedicine & Pharmacotherapy. Issy-les-moulineaux: Elsevier France-editions Scientifiques Medicales Elsevier, v. 111, p. 331-337, 2019.0753-3322http://hdl.handle.net/11449/18664010.1016/j.biopha.2018.12.091WOS:000458737800036Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiomedicine & Pharmacotherapyinfo:eu-repo/semantics/openAccess2024-06-21T15:19:10Zoai:repositorio.unesp.br:11449/186640Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:41:20.314266Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis |
title |
Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis |
spellingShingle |
Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis Senedese, Juliana Marques Copaifera reticulata Ducke ent-polyalthic acid Antigenotoxicity Anticarcinogenesis Anti-inflammatory activity |
title_short |
Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis |
title_full |
Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis |
title_fullStr |
Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis |
title_full_unstemmed |
Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis |
title_sort |
Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis |
author |
Senedese, Juliana Marques |
author_facet |
Senedese, Juliana Marques Rinaldi-Neto, Francisco Furtado, Ricardo Andrade Nicollela, Heloiza Diniz Ribeiro de Souza, Larissa Daniela Ribeiro, Arthur Barcelos Ferreira, Lucas Souza [UNESP] Magalhaes, Georgia Mode Carlos, Iracilda Zeppone [UNESP] Mangabeira da Silva, Jonas Joaquim Tavares, Denise Crispim Bastos, Jairo Kenupp |
author_role |
author |
author2 |
Rinaldi-Neto, Francisco Furtado, Ricardo Andrade Nicollela, Heloiza Diniz Ribeiro de Souza, Larissa Daniela Ribeiro, Arthur Barcelos Ferreira, Lucas Souza [UNESP] Magalhaes, Georgia Mode Carlos, Iracilda Zeppone [UNESP] Mangabeira da Silva, Jonas Joaquim Tavares, Denise Crispim Bastos, Jairo Kenupp |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Univ Franca Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Senedese, Juliana Marques Rinaldi-Neto, Francisco Furtado, Ricardo Andrade Nicollela, Heloiza Diniz Ribeiro de Souza, Larissa Daniela Ribeiro, Arthur Barcelos Ferreira, Lucas Souza [UNESP] Magalhaes, Georgia Mode Carlos, Iracilda Zeppone [UNESP] Mangabeira da Silva, Jonas Joaquim Tavares, Denise Crispim Bastos, Jairo Kenupp |
dc.subject.por.fl_str_mv |
Copaifera reticulata Ducke ent-polyalthic acid Antigenotoxicity Anticarcinogenesis Anti-inflammatory activity |
topic |
Copaifera reticulata Ducke ent-polyalthic acid Antigenotoxicity Anticarcinogenesis Anti-inflammatory activity |
description |
In Brazilian folk medicine, copaiba oleoresin is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Considering the relationship between inflammatory processes and carcinogenesis, this paper reports on the Copaifera reticulata Ducke oleoresin (CRO) chemopreventive potential in the colon carcinogenesis model in rats. To understand the mechanisms involved in this effect, the anti-inflammatory activity of CRO and its major chemical constituent, the diterpene ent-polyalthic acid (PA), were evaluated on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in mouse macrophages. For the chemoprevention assessment, the effect of CRO administered by gavage was investigated on DNA damage, preneoplastic lesions and mitotic frequencies induced by the 1,2-dimethylhydrazine (DMH; intraperitoneal injection) carcinogen by comet, aberrant crypt focus (ACF) and long-term assays, respectively. CRO reduced DNA damage (average 31.5%) and pre-neoplastic lesions (average 64.5%) induced by DMH, which revealed that CRO has antigenotoxic and anticarcinogenic effects. In the long-term assay, treatment with CRO significantly decreased mitoses in the tumor tissue, which suggested that CRO influenced carcinogenesis progression. PA reduced NO levels induced by lipopolysaccharides in macrophages. However, this diterpene showed no effect on PGE2. Taken together, our results suggest that PA exerts anti-inflammatory action via the NO pathway. The CRO chemopreventive effect may be partly due to the anti-inflammatory property of its major chemical constituent, PA. Our findings indicate that CRO is a promising agent to suppress colon carcinogenesis. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-05T13:16:58Z 2019-10-05T13:16:58Z 2019-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.biopha.2018.12.091 Biomedicine & Pharmacotherapy. Issy-les-moulineaux: Elsevier France-editions Scientifiques Medicales Elsevier, v. 111, p. 331-337, 2019. 0753-3322 http://hdl.handle.net/11449/186640 10.1016/j.biopha.2018.12.091 WOS:000458737800036 |
url |
http://dx.doi.org/10.1016/j.biopha.2018.12.091 http://hdl.handle.net/11449/186640 |
identifier_str_mv |
Biomedicine & Pharmacotherapy. Issy-les-moulineaux: Elsevier France-editions Scientifiques Medicales Elsevier, v. 111, p. 331-337, 2019. 0753-3322 10.1016/j.biopha.2018.12.091 WOS:000458737800036 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biomedicine & Pharmacotherapy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
331-337 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129234519982080 |