Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis

Detalhes bibliográficos
Autor(a) principal: Senedese, Juliana Marques
Data de Publicação: 2019
Outros Autores: Rinaldi-Neto, Francisco, Furtado, Ricardo Andrade, Nicollela, Heloiza Diniz, Ribeiro de Souza, Larissa Daniela, Ribeiro, Arthur Barcelos, Ferreira, Lucas Souza [UNESP], Magalhaes, Georgia Mode, Carlos, Iracilda Zeppone [UNESP], Mangabeira da Silva, Jonas Joaquim, Tavares, Denise Crispim, Bastos, Jairo Kenupp
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.biopha.2018.12.091
http://hdl.handle.net/11449/186640
Resumo: In Brazilian folk medicine, copaiba oleoresin is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Considering the relationship between inflammatory processes and carcinogenesis, this paper reports on the Copaifera reticulata Ducke oleoresin (CRO) chemopreventive potential in the colon carcinogenesis model in rats. To understand the mechanisms involved in this effect, the anti-inflammatory activity of CRO and its major chemical constituent, the diterpene ent-polyalthic acid (PA), were evaluated on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in mouse macrophages. For the chemoprevention assessment, the effect of CRO administered by gavage was investigated on DNA damage, preneoplastic lesions and mitotic frequencies induced by the 1,2-dimethylhydrazine (DMH; intraperitoneal injection) carcinogen by comet, aberrant crypt focus (ACF) and long-term assays, respectively. CRO reduced DNA damage (average 31.5%) and pre-neoplastic lesions (average 64.5%) induced by DMH, which revealed that CRO has antigenotoxic and anticarcinogenic effects. In the long-term assay, treatment with CRO significantly decreased mitoses in the tumor tissue, which suggested that CRO influenced carcinogenesis progression. PA reduced NO levels induced by lipopolysaccharides in macrophages. However, this diterpene showed no effect on PGE2. Taken together, our results suggest that PA exerts anti-inflammatory action via the NO pathway. The CRO chemopreventive effect may be partly due to the anti-inflammatory property of its major chemical constituent, PA. Our findings indicate that CRO is a promising agent to suppress colon carcinogenesis.
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spelling Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesisCopaifera reticulata Duckeent-polyalthic acidAntigenotoxicityAnticarcinogenesisAnti-inflammatory activityIn Brazilian folk medicine, copaiba oleoresin is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Considering the relationship between inflammatory processes and carcinogenesis, this paper reports on the Copaifera reticulata Ducke oleoresin (CRO) chemopreventive potential in the colon carcinogenesis model in rats. To understand the mechanisms involved in this effect, the anti-inflammatory activity of CRO and its major chemical constituent, the diterpene ent-polyalthic acid (PA), were evaluated on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in mouse macrophages. For the chemoprevention assessment, the effect of CRO administered by gavage was investigated on DNA damage, preneoplastic lesions and mitotic frequencies induced by the 1,2-dimethylhydrazine (DMH; intraperitoneal injection) carcinogen by comet, aberrant crypt focus (ACF) and long-term assays, respectively. CRO reduced DNA damage (average 31.5%) and pre-neoplastic lesions (average 64.5%) induced by DMH, which revealed that CRO has antigenotoxic and anticarcinogenic effects. In the long-term assay, treatment with CRO significantly decreased mitoses in the tumor tissue, which suggested that CRO influenced carcinogenesis progression. PA reduced NO levels induced by lipopolysaccharides in macrophages. However, this diterpene showed no effect on PGE2. Taken together, our results suggest that PA exerts anti-inflammatory action via the NO pathway. The CRO chemopreventive effect may be partly due to the anti-inflammatory property of its major chemical constituent, PA. Our findings indicate that CRO is a promising agent to suppress colon carcinogenesis.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Paulo, Sch Pharmaceut Sci, BR-14040903 Ribeirao Preto, SP, BrazilUniv Franca, Ave Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Rodovia Araraquara Jau Km 1, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Rodovia Araraquara Jau Km 1, BR-14801902 Araraquara, SP, BrazilFAPESP: 2011/13630-7FAPESP: 2013/19488-3Elsevier B.V.Universidade de São Paulo (USP)Univ FrancaUniversidade Estadual Paulista (Unesp)Senedese, Juliana MarquesRinaldi-Neto, FranciscoFurtado, Ricardo AndradeNicollela, Heloiza DinizRibeiro de Souza, Larissa DanielaRibeiro, Arthur BarcelosFerreira, Lucas Souza [UNESP]Magalhaes, Georgia ModeCarlos, Iracilda Zeppone [UNESP]Mangabeira da Silva, Jonas JoaquimTavares, Denise CrispimBastos, Jairo Kenupp2019-10-05T13:16:58Z2019-10-05T13:16:58Z2019-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article331-337http://dx.doi.org/10.1016/j.biopha.2018.12.091Biomedicine & Pharmacotherapy. Issy-les-moulineaux: Elsevier France-editions Scientifiques Medicales Elsevier, v. 111, p. 331-337, 2019.0753-3322http://hdl.handle.net/11449/18664010.1016/j.biopha.2018.12.091WOS:000458737800036Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiomedicine & Pharmacotherapyinfo:eu-repo/semantics/openAccess2024-06-21T15:19:10Zoai:repositorio.unesp.br:11449/186640Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:41:20.314266Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
title Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
spellingShingle Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
Senedese, Juliana Marques
Copaifera reticulata Ducke
ent-polyalthic acid
Antigenotoxicity
Anticarcinogenesis
Anti-inflammatory activity
title_short Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
title_full Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
title_fullStr Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
title_full_unstemmed Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
title_sort Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis
author Senedese, Juliana Marques
author_facet Senedese, Juliana Marques
Rinaldi-Neto, Francisco
Furtado, Ricardo Andrade
Nicollela, Heloiza Diniz
Ribeiro de Souza, Larissa Daniela
Ribeiro, Arthur Barcelos
Ferreira, Lucas Souza [UNESP]
Magalhaes, Georgia Mode
Carlos, Iracilda Zeppone [UNESP]
Mangabeira da Silva, Jonas Joaquim
Tavares, Denise Crispim
Bastos, Jairo Kenupp
author_role author
author2 Rinaldi-Neto, Francisco
Furtado, Ricardo Andrade
Nicollela, Heloiza Diniz
Ribeiro de Souza, Larissa Daniela
Ribeiro, Arthur Barcelos
Ferreira, Lucas Souza [UNESP]
Magalhaes, Georgia Mode
Carlos, Iracilda Zeppone [UNESP]
Mangabeira da Silva, Jonas Joaquim
Tavares, Denise Crispim
Bastos, Jairo Kenupp
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Univ Franca
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Senedese, Juliana Marques
Rinaldi-Neto, Francisco
Furtado, Ricardo Andrade
Nicollela, Heloiza Diniz
Ribeiro de Souza, Larissa Daniela
Ribeiro, Arthur Barcelos
Ferreira, Lucas Souza [UNESP]
Magalhaes, Georgia Mode
Carlos, Iracilda Zeppone [UNESP]
Mangabeira da Silva, Jonas Joaquim
Tavares, Denise Crispim
Bastos, Jairo Kenupp
dc.subject.por.fl_str_mv Copaifera reticulata Ducke
ent-polyalthic acid
Antigenotoxicity
Anticarcinogenesis
Anti-inflammatory activity
topic Copaifera reticulata Ducke
ent-polyalthic acid
Antigenotoxicity
Anticarcinogenesis
Anti-inflammatory activity
description In Brazilian folk medicine, copaiba oleoresin is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Considering the relationship between inflammatory processes and carcinogenesis, this paper reports on the Copaifera reticulata Ducke oleoresin (CRO) chemopreventive potential in the colon carcinogenesis model in rats. To understand the mechanisms involved in this effect, the anti-inflammatory activity of CRO and its major chemical constituent, the diterpene ent-polyalthic acid (PA), were evaluated on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in mouse macrophages. For the chemoprevention assessment, the effect of CRO administered by gavage was investigated on DNA damage, preneoplastic lesions and mitotic frequencies induced by the 1,2-dimethylhydrazine (DMH; intraperitoneal injection) carcinogen by comet, aberrant crypt focus (ACF) and long-term assays, respectively. CRO reduced DNA damage (average 31.5%) and pre-neoplastic lesions (average 64.5%) induced by DMH, which revealed that CRO has antigenotoxic and anticarcinogenic effects. In the long-term assay, treatment with CRO significantly decreased mitoses in the tumor tissue, which suggested that CRO influenced carcinogenesis progression. PA reduced NO levels induced by lipopolysaccharides in macrophages. However, this diterpene showed no effect on PGE2. Taken together, our results suggest that PA exerts anti-inflammatory action via the NO pathway. The CRO chemopreventive effect may be partly due to the anti-inflammatory property of its major chemical constituent, PA. Our findings indicate that CRO is a promising agent to suppress colon carcinogenesis.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-05T13:16:58Z
2019-10-05T13:16:58Z
2019-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.biopha.2018.12.091
Biomedicine & Pharmacotherapy. Issy-les-moulineaux: Elsevier France-editions Scientifiques Medicales Elsevier, v. 111, p. 331-337, 2019.
0753-3322
http://hdl.handle.net/11449/186640
10.1016/j.biopha.2018.12.091
WOS:000458737800036
url http://dx.doi.org/10.1016/j.biopha.2018.12.091
http://hdl.handle.net/11449/186640
identifier_str_mv Biomedicine & Pharmacotherapy. Issy-les-moulineaux: Elsevier France-editions Scientifiques Medicales Elsevier, v. 111, p. 331-337, 2019.
0753-3322
10.1016/j.biopha.2018.12.091
WOS:000458737800036
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biomedicine & Pharmacotherapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 331-337
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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