Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.micpath.2022.105725 http://hdl.handle.net/11449/240750 |
Resumo: | Among the important recent observations involving anaerobic respiration was that an electron acceptor produced as a result of an inflammatory response to Salmonella Typhimurium generates a growth advantage over the competing microbiota in the lumen. In this regard, anaerobically, salmonellae can oxidize thiosulphate (S2O32−) converting it into tetrathionate (S4O62−), the process by which it is encoded by ttr gene cluster (ttrSRttrBCA). Another important pathway under aerobic or anaerobic conditions is the 1,2-propanediol-utilization mediated by the pdu gene cluster that promotes Salmonella expansion during colitis. Therefore, we sought to compare in this study, whether Salmonella Heidelberg strains lacking the ttrA, ttrApduA, and ttrACBSR genes experience a disadvantage during cecal colonization in broiler chicks. In contrast to expectations, we found that the gene loss in S. Heidelberg potentially confers an increase in fitness in the chicken infection model. These data argue that S. Heidelberg may trigger an alternative pathway involving the use of an alternative electron acceptor, conferring a growth advantage for S. Heidelberg in chicks. |
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Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model1,2-PropanediolAnaerobic respirationSalmonellosisTetrathionateAmong the important recent observations involving anaerobic respiration was that an electron acceptor produced as a result of an inflammatory response to Salmonella Typhimurium generates a growth advantage over the competing microbiota in the lumen. In this regard, anaerobically, salmonellae can oxidize thiosulphate (S2O32−) converting it into tetrathionate (S4O62−), the process by which it is encoded by ttr gene cluster (ttrSRttrBCA). Another important pathway under aerobic or anaerobic conditions is the 1,2-propanediol-utilization mediated by the pdu gene cluster that promotes Salmonella expansion during colitis. Therefore, we sought to compare in this study, whether Salmonella Heidelberg strains lacking the ttrA, ttrApduA, and ttrACBSR genes experience a disadvantage during cecal colonization in broiler chicks. In contrast to expectations, we found that the gene loss in S. Heidelberg potentially confers an increase in fitness in the chicken infection model. These data argue that S. Heidelberg may trigger an alternative pathway involving the use of an alternative electron acceptor, conferring a growth advantage for S. Heidelberg in chicks.São Paulo State University (Unesp) School of Agricultural and Veterinarian Sciences, Jaboticabal, SPSchool of Veterinary Medicine and Science University of Surrey, GuildfordDepartment of Preventive Veterinary Medicine Veterinary School Federal University of Minas Gerais (UFMG), MGSão Paulo State University (Unesp) School of Agricultural and Veterinarian Sciences, Jaboticabal, SPUniversidade Estadual Paulista (UNESP)University of SurreyUniversidade Federal de Minas Gerais (UFMG)Góes, Vinícius [UNESP]Monte, Daniel F.M. [UNESP]Saraiva, Mauro de Mesquita Souza [UNESP]Almeida, Adriana Maria de [UNESP]Cabrera, Julia Memrava [UNESP]Alves, Lucas Bocchini Rodrigues [UNESP]Ferreira, Taísa Santiago [UNESP]Lima, Tulio Spina de [UNESP]Benevides, Valdinete P. [UNESP]Barrow, Paul A.Freitas Neto, Oliveiro Caetano deBerchieri Jr, Angelo [UNESP]2023-03-01T20:31:16Z2023-03-01T20:31:16Z2022-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.micpath.2022.105725Microbial Pathogenesis, v. 171.1096-12080882-4010http://hdl.handle.net/11449/24075010.1016/j.micpath.2022.1057252-s2.0-85137111129Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMicrobial Pathogenesisinfo:eu-repo/semantics/openAccess2023-03-01T20:31:16Zoai:repositorio.unesp.br:11449/240750Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:17:53.932482Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model |
title |
Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model |
spellingShingle |
Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model Góes, Vinícius [UNESP] 1,2-Propanediol Anaerobic respiration Salmonellosis Tetrathionate |
title_short |
Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model |
title_full |
Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model |
title_fullStr |
Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model |
title_full_unstemmed |
Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model |
title_sort |
Salmonella Heidelberg side-step gene loss of respiratory requirements in chicken infection model |
author |
Góes, Vinícius [UNESP] |
author_facet |
Góes, Vinícius [UNESP] Monte, Daniel F.M. [UNESP] Saraiva, Mauro de Mesquita Souza [UNESP] Almeida, Adriana Maria de [UNESP] Cabrera, Julia Memrava [UNESP] Alves, Lucas Bocchini Rodrigues [UNESP] Ferreira, Taísa Santiago [UNESP] Lima, Tulio Spina de [UNESP] Benevides, Valdinete P. [UNESP] Barrow, Paul A. Freitas Neto, Oliveiro Caetano de Berchieri Jr, Angelo [UNESP] |
author_role |
author |
author2 |
Monte, Daniel F.M. [UNESP] Saraiva, Mauro de Mesquita Souza [UNESP] Almeida, Adriana Maria de [UNESP] Cabrera, Julia Memrava [UNESP] Alves, Lucas Bocchini Rodrigues [UNESP] Ferreira, Taísa Santiago [UNESP] Lima, Tulio Spina de [UNESP] Benevides, Valdinete P. [UNESP] Barrow, Paul A. Freitas Neto, Oliveiro Caetano de Berchieri Jr, Angelo [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) University of Surrey Universidade Federal de Minas Gerais (UFMG) |
dc.contributor.author.fl_str_mv |
Góes, Vinícius [UNESP] Monte, Daniel F.M. [UNESP] Saraiva, Mauro de Mesquita Souza [UNESP] Almeida, Adriana Maria de [UNESP] Cabrera, Julia Memrava [UNESP] Alves, Lucas Bocchini Rodrigues [UNESP] Ferreira, Taísa Santiago [UNESP] Lima, Tulio Spina de [UNESP] Benevides, Valdinete P. [UNESP] Barrow, Paul A. Freitas Neto, Oliveiro Caetano de Berchieri Jr, Angelo [UNESP] |
dc.subject.por.fl_str_mv |
1,2-Propanediol Anaerobic respiration Salmonellosis Tetrathionate |
topic |
1,2-Propanediol Anaerobic respiration Salmonellosis Tetrathionate |
description |
Among the important recent observations involving anaerobic respiration was that an electron acceptor produced as a result of an inflammatory response to Salmonella Typhimurium generates a growth advantage over the competing microbiota in the lumen. In this regard, anaerobically, salmonellae can oxidize thiosulphate (S2O32−) converting it into tetrathionate (S4O62−), the process by which it is encoded by ttr gene cluster (ttrSRttrBCA). Another important pathway under aerobic or anaerobic conditions is the 1,2-propanediol-utilization mediated by the pdu gene cluster that promotes Salmonella expansion during colitis. Therefore, we sought to compare in this study, whether Salmonella Heidelberg strains lacking the ttrA, ttrApduA, and ttrACBSR genes experience a disadvantage during cecal colonization in broiler chicks. In contrast to expectations, we found that the gene loss in S. Heidelberg potentially confers an increase in fitness in the chicken infection model. These data argue that S. Heidelberg may trigger an alternative pathway involving the use of an alternative electron acceptor, conferring a growth advantage for S. Heidelberg in chicks. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-01 2023-03-01T20:31:16Z 2023-03-01T20:31:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.micpath.2022.105725 Microbial Pathogenesis, v. 171. 1096-1208 0882-4010 http://hdl.handle.net/11449/240750 10.1016/j.micpath.2022.105725 2-s2.0-85137111129 |
url |
http://dx.doi.org/10.1016/j.micpath.2022.105725 http://hdl.handle.net/11449/240750 |
identifier_str_mv |
Microbial Pathogenesis, v. 171. 1096-1208 0882-4010 10.1016/j.micpath.2022.105725 2-s2.0-85137111129 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Microbial Pathogenesis |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129048432345088 |