Influence of the inflammatory response on treatment of hepatitis C with triple therapy
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0037-8682-0137-2018 http://hdl.handle.net/11449/185148 |
Resumo: | Introduction: Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytokine imbalance and ultimately affecting treatment. Studies using interferon (IFN) and ribavirin (RBV) showed that TCD8+ cells and cytokine levels are associated with sustainable virological response (SVR). However, studies that investigated the effects of triple therapy (TT) are limited. Methods: The study included hepatitis C virus (HCV)+ RNA, naives, genotype 1, >= 18 years. and advanced fibrosis (F >= 3) patients. Samples were collected at baseline and after 12 weeks (W12) of TT. Six cytokines were analyzed by flow cytometly. Results: Of 31 patients, four were excluded (two deaths, one interrupted TT, and one F2 patient). Of the 27 remaining patients, 21(78%) were cirrhotic. SVR was achieved in 63% of the patients. The patients had a mean age of 55.11 +/- 10.03 years. Analyses at baseline showed that the chemokine CCL5/Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) (p=1.04) and interleukin (IL)-6 (p=0.02), which was associated with SVR. RANTES (p=0.04) and IL-8 (p=0.01) levels were associated with SVR at W12. Conclusions: Similar to patterns observed during double therapy, IL-6, IL-8, and RANTES levels were associated with SVR in TT, indicating the potential role of interferon in immune response to hepatitis C virus. |
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Influence of the inflammatory response on treatment of hepatitis C with triple therapyHepatitis CCytokineTreatmentIntroduction: Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytokine imbalance and ultimately affecting treatment. Studies using interferon (IFN) and ribavirin (RBV) showed that TCD8+ cells and cytokine levels are associated with sustainable virological response (SVR). However, studies that investigated the effects of triple therapy (TT) are limited. Methods: The study included hepatitis C virus (HCV)+ RNA, naives, genotype 1, >= 18 years. and advanced fibrosis (F >= 3) patients. Samples were collected at baseline and after 12 weeks (W12) of TT. Six cytokines were analyzed by flow cytometly. Results: Of 31 patients, four were excluded (two deaths, one interrupted TT, and one F2 patient). Of the 27 remaining patients, 21(78%) were cirrhotic. SVR was achieved in 63% of the patients. The patients had a mean age of 55.11 +/- 10.03 years. Analyses at baseline showed that the chemokine CCL5/Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) (p=1.04) and interleukin (IL)-6 (p=0.02), which was associated with SVR. RANTES (p=0.04) and IL-8 (p=0.01) levels were associated with SVR at W12. Conclusions: Similar to patterns observed during double therapy, IL-6, IL-8, and RANTES levels were associated with SVR in TT, indicating the potential role of interferon in immune response to hepatitis C virus.Univ Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, BrazilUniv Estadual Paulista, Hemoctr, Lab Citometria Fluxo, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias, Dept Bioestat, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, BrazilUniv Estadual Paulista, Hemoctr, Lab Citometria Fluxo, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias, Dept Bioestat, Botucatu, SP, BrazilSoc Brasileira Medicina TropicalUniversidade Estadual Paulista (Unesp)Winckler, Fernanda Cristina [UNESP]Marques Braz, Aline Marcia [UNESP]Silva, Vanessa Nogueira da [UNESP]Golim, Marjorie de Assis [UNESP]Andrade, Vanessa Gutierrez de [UNESP]Abreu Machado, Paulo Eduardo de [UNESP]Arruda Silveira, Liciana Vaz de [UNESP]Silva, Giovanni Faria [UNESP]2019-10-04T12:33:04Z2019-10-04T12:33:04Z2018-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article731-736application/pdfhttp://dx.doi.org/10.1590/0037-8682-0137-2018Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 51, n. 6, p. 731-736, 2018.0037-8682http://hdl.handle.net/11449/18514810.1590/0037-8682-0137-2018S0037-86822018000600731WOS:000451926100002S0037-86822018000600731.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Da Sociedade Brasileira De Medicina Tropicalinfo:eu-repo/semantics/openAccess2024-08-14T17:22:59Zoai:repositorio.unesp.br:11449/185148Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of the inflammatory response on treatment of hepatitis C with triple therapy |
title |
Influence of the inflammatory response on treatment of hepatitis C with triple therapy |
spellingShingle |
Influence of the inflammatory response on treatment of hepatitis C with triple therapy Winckler, Fernanda Cristina [UNESP] Hepatitis C Cytokine Treatment |
title_short |
Influence of the inflammatory response on treatment of hepatitis C with triple therapy |
title_full |
Influence of the inflammatory response on treatment of hepatitis C with triple therapy |
title_fullStr |
Influence of the inflammatory response on treatment of hepatitis C with triple therapy |
title_full_unstemmed |
Influence of the inflammatory response on treatment of hepatitis C with triple therapy |
title_sort |
Influence of the inflammatory response on treatment of hepatitis C with triple therapy |
author |
Winckler, Fernanda Cristina [UNESP] |
author_facet |
Winckler, Fernanda Cristina [UNESP] Marques Braz, Aline Marcia [UNESP] Silva, Vanessa Nogueira da [UNESP] Golim, Marjorie de Assis [UNESP] Andrade, Vanessa Gutierrez de [UNESP] Abreu Machado, Paulo Eduardo de [UNESP] Arruda Silveira, Liciana Vaz de [UNESP] Silva, Giovanni Faria [UNESP] |
author_role |
author |
author2 |
Marques Braz, Aline Marcia [UNESP] Silva, Vanessa Nogueira da [UNESP] Golim, Marjorie de Assis [UNESP] Andrade, Vanessa Gutierrez de [UNESP] Abreu Machado, Paulo Eduardo de [UNESP] Arruda Silveira, Liciana Vaz de [UNESP] Silva, Giovanni Faria [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Winckler, Fernanda Cristina [UNESP] Marques Braz, Aline Marcia [UNESP] Silva, Vanessa Nogueira da [UNESP] Golim, Marjorie de Assis [UNESP] Andrade, Vanessa Gutierrez de [UNESP] Abreu Machado, Paulo Eduardo de [UNESP] Arruda Silveira, Liciana Vaz de [UNESP] Silva, Giovanni Faria [UNESP] |
dc.subject.por.fl_str_mv |
Hepatitis C Cytokine Treatment |
topic |
Hepatitis C Cytokine Treatment |
description |
Introduction: Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytokine imbalance and ultimately affecting treatment. Studies using interferon (IFN) and ribavirin (RBV) showed that TCD8+ cells and cytokine levels are associated with sustainable virological response (SVR). However, studies that investigated the effects of triple therapy (TT) are limited. Methods: The study included hepatitis C virus (HCV)+ RNA, naives, genotype 1, >= 18 years. and advanced fibrosis (F >= 3) patients. Samples were collected at baseline and after 12 weeks (W12) of TT. Six cytokines were analyzed by flow cytometly. Results: Of 31 patients, four were excluded (two deaths, one interrupted TT, and one F2 patient). Of the 27 remaining patients, 21(78%) were cirrhotic. SVR was achieved in 63% of the patients. The patients had a mean age of 55.11 +/- 10.03 years. Analyses at baseline showed that the chemokine CCL5/Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) (p=1.04) and interleukin (IL)-6 (p=0.02), which was associated with SVR. RANTES (p=0.04) and IL-8 (p=0.01) levels were associated with SVR at W12. Conclusions: Similar to patterns observed during double therapy, IL-6, IL-8, and RANTES levels were associated with SVR in TT, indicating the potential role of interferon in immune response to hepatitis C virus. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-01 2019-10-04T12:33:04Z 2019-10-04T12:33:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0037-8682-0137-2018 Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 51, n. 6, p. 731-736, 2018. 0037-8682 http://hdl.handle.net/11449/185148 10.1590/0037-8682-0137-2018 S0037-86822018000600731 WOS:000451926100002 S0037-86822018000600731.pdf |
url |
http://dx.doi.org/10.1590/0037-8682-0137-2018 http://hdl.handle.net/11449/185148 |
identifier_str_mv |
Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 51, n. 6, p. 731-736, 2018. 0037-8682 10.1590/0037-8682-0137-2018 S0037-86822018000600731 WOS:000451926100002 S0037-86822018000600731.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Da Sociedade Brasileira De Medicina Tropical |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
731-736 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasileira Medicina Tropical |
publisher.none.fl_str_mv |
Soc Brasileira Medicina Tropical |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128141461291008 |