Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection

Detalhes bibliográficos
Autor(a) principal: Pereira, Fernanda Albuquerque
Data de Publicação: 2008
Outros Autores: Silva, Naize Nara Pinheiro da, Rodart, Itatiana Ferreira, Carmo, Theomira Mauadie Azevedo, Lemaire, Denise Carneiro, Reis, Mitermayer Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14208
Resumo: Texto completo: acesso restrito. p. 58-64
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spelling Pereira, Fernanda AlbuquerqueSilva, Naize Nara Pinheiro daRodart, Itatiana FerreiraCarmo, Theomira Mauadie AzevedoLemaire, Denise CarneiroReis, Mitermayer GalvãoPereira, Fernanda AlbuquerqueSilva, Naize Nara Pinheiro daRodart, Itatiana FerreiraCarmo, Theomira Mauadie AzevedoLemaire, Denise CarneiroReis, Mitermayer Galvão2013-12-17T16:02:12Z20080146-6615http://repositorio.ufba.br/ri/handle/ri/14208v. 80, n. 1Texto completo: acesso restrito. p. 58-64Cytokines play a key role in the regulation of immune responses. In hepatitis C virus infection (HCV), the production of abnormal cytokine levels appears to contribute to the progression of the disease, viral persistence, and affects response to therapy. Cytokine genes are polymorphic at specific sites, and certain polymorphisms located within coding/regulatory regions have been shown to affect the overall expression and secretion of cytokines. The aim of the present study was to identify potential markers of cytokines genes associated with the susceptibility to HCV infection. The cohort was composed of 128 individuals infected by HCV and 94 healthy controls. Genotyping was carried out by PCR-SSP. The distributions of the following polymorphisms were compared in these groups: TNF-α (−308G/A [rs1800629]), TGF-β1 (codon 10 T/C [rs1982073], codon 25 G/C [rs1800471]), IL-10 (−1082 A/G [rs 1800896]; −819T/C [rs1800871]; −592A/C [rs 1800872]), IL-6 (−174G/C [rs1800795]), and IFN-γ (+874T/A [rs2430561]). This study demonstrated a statistically significant difference in the frequency of TGF-β1 codon 25 polymorphism between healthy subjects and those infected with HCV. No associations were observed between polymorphisms of TNF-α, IFN-γ, IL-10, TGF-β1 codon 10, and IL-6 and HCV infection. These findings suggest that TGF-β1 codon 25 polymorphism could be a host genetic factor associated with susceptibility to HCV infection.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-17T10:37:23Z No. of bitstreams: 1 10.1002jmv.21011.pdf: 118428 bytes, checksum: b99cd45762246fcf378e3ff767691dfa (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2013-12-17T16:02:11Z (GMT) No. of bitstreams: 1 10.1002jmv.21011.pdf: 118428 bytes, checksum: b99cd45762246fcf378e3ff767691dfa (MD5)Made available in DSpace on 2013-12-17T16:02:12Z (GMT). No. of bitstreams: 1 10.1002jmv.21011.pdf: 118428 bytes, checksum: b99cd45762246fcf378e3ff767691dfa (MD5) Previous issue date: 2008http://dx.doi.org/10.1002/jmv.21011reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHepatitis CGenesCytokinesPolymorphism (genetics)Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infectionJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1002jmv.21011.pdf10.1002jmv.21011.pdfapplication/pdf118428https://repositorio.ufba.br/bitstream/ri/14208/1/10.1002jmv.21011.pdfb99cd45762246fcf378e3ff767691dfaMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14208/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT10.1002jmv.21011.pdf.txt10.1002jmv.21011.pdf.txtExtracted texttext/plain37233https://repositorio.ufba.br/bitstream/ri/14208/3/10.1002jmv.21011.pdf.txtc125d3d46b979c536cf44fb7ace76e5fMD53ri/142082022-08-08 13:19:52.17oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:19:52Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
dc.title.alternative.pt_BR.fl_str_mv Journal of Medical Virology
title Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
spellingShingle Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
Pereira, Fernanda Albuquerque
Hepatitis C
Genes
Cytokines
Polymorphism (genetics)
title_short Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
title_full Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
title_fullStr Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
title_full_unstemmed Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
title_sort Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
author Pereira, Fernanda Albuquerque
author_facet Pereira, Fernanda Albuquerque
Silva, Naize Nara Pinheiro da
Rodart, Itatiana Ferreira
Carmo, Theomira Mauadie Azevedo
Lemaire, Denise Carneiro
Reis, Mitermayer Galvão
author_role author
author2 Silva, Naize Nara Pinheiro da
Rodart, Itatiana Ferreira
Carmo, Theomira Mauadie Azevedo
Lemaire, Denise Carneiro
Reis, Mitermayer Galvão
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Fernanda Albuquerque
Silva, Naize Nara Pinheiro da
Rodart, Itatiana Ferreira
Carmo, Theomira Mauadie Azevedo
Lemaire, Denise Carneiro
Reis, Mitermayer Galvão
Pereira, Fernanda Albuquerque
Silva, Naize Nara Pinheiro da
Rodart, Itatiana Ferreira
Carmo, Theomira Mauadie Azevedo
Lemaire, Denise Carneiro
Reis, Mitermayer Galvão
dc.subject.por.fl_str_mv Hepatitis C
Genes
Cytokines
Polymorphism (genetics)
topic Hepatitis C
Genes
Cytokines
Polymorphism (genetics)
description Texto completo: acesso restrito. p. 58-64
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-12-17T16:02:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14208
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.number.pt_BR.fl_str_mv v. 80, n. 1
identifier_str_mv 0146-6615
v. 80, n. 1
url http://repositorio.ufba.br/ri/handle/ri/14208
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1002/jmv.21011
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