The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/v14071481 http://hdl.handle.net/11449/240446 |
Resumo: | Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations. |
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The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of IlhabelaBrazilmolecular epidemiologySARS-CoV-2variants of concern (VOC)Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Butantan Institute, SPBlood Center of Ribeirão Preto Ribeirão Preto Medical School University of São Paulo, SPCentro de Genômica Funcional da ESALQ University of São Paulo, SPMedicine School of São José do Rio Preto (FAMERP), SPDepartment of Veterinary Medicine School of Animal Science and Food Engineering University of Sao Paulo, SPDepartment of Bioprocesses and Biotechnology School of Agricultural Sciences São Paulo State University (UNESP), SPSchool of Agricultural Sciences São Paulo State University (UNESP), SPVigilância Epidemiológica de Ilhabela, SPHospital Mario Covas Junior, SPInstituto de Ciências Biológicas Universidade Federal de Minas Gerais, MGInstituto Oswaldo Cruz FIOCRUZ, RJReference Laboratory of Flavivirus Oswaldo Cruz Foundation, RJDepartment of Science and Technology for Humans and the Environment University of Campus Bio-Medico di RomaMolecular Biology and Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School, SPDepartment of Bioprocesses and Biotechnology School of Agricultural Sciences São Paulo State University (UNESP), SPSchool of Agricultural Sciences São Paulo State University (UNESP), SPMolecular Biology and Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School, SPFAPESP: 18/15826-5FAPESP: 2020/06441-2FAPESP: 2020/10127-1Butantan InstituteUniversidade de São Paulo (USP)Medicine School of São José do Rio Preto (FAMERP)Universidade Estadual Paulista (UNESP)Vigilância Epidemiológica de IlhabelaHospital Mario Covas JuniorUniversidade Federal de Minas Gerais (UFMG)FIOCRUZOswaldo Cruz FoundationUniversity of Campus Bio-Medico di RomaViala, Vincent LouisSlavov, Svetoslav NanevLima, Loyze Paola Oliveira deLima, Alex Ranieri JeronimoRibeiro, GabrielaMartins, Antonio JorgePetry, BrunaBanhode Souza Todao LacerdaPoleti, Mirele DaianaAssato, Patricia Akemi [UNESP]Cattony Neto, Pedro De QueirozCassano, Raquel de Lello Rocha CamposMachado Neto, RaulGrotto, Rejane Maria Tommasini [UNESP]Brassaloti, Ricardo AugustoKashima, SimoneCovas, Dimas TadeuElias, Maria CarolinaSampaio, Sandra Coccuzzo2023-03-01T20:17:31Z2023-03-01T20:17:31Z2022-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/v14071481Viruses, v. 14, n. 7, 2022.1999-4915http://hdl.handle.net/11449/24044610.3390/v140714812-s2.0-85133926259Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVirusesinfo:eu-repo/semantics/openAccess2023-03-01T20:17:31Zoai:repositorio.unesp.br:11449/240446Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:00:10.417722Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela |
title |
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela |
spellingShingle |
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela Viala, Vincent Louis Brazil molecular epidemiology SARS-CoV-2 variants of concern (VOC) |
title_short |
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela |
title_full |
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela |
title_fullStr |
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela |
title_full_unstemmed |
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela |
title_sort |
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela |
author |
Viala, Vincent Louis |
author_facet |
Viala, Vincent Louis Slavov, Svetoslav Nanev Lima, Loyze Paola Oliveira de Lima, Alex Ranieri Jeronimo Ribeiro, Gabriela Martins, Antonio Jorge Petry, Bruna Banhode Souza Todao Lacerda Poleti, Mirele Daiana Assato, Patricia Akemi [UNESP] Cattony Neto, Pedro De Queiroz Cassano, Raquel de Lello Rocha Campos Machado Neto, Raul Grotto, Rejane Maria Tommasini [UNESP] Brassaloti, Ricardo Augusto Kashima, Simone Covas, Dimas Tadeu Elias, Maria Carolina Sampaio, Sandra Coccuzzo |
author_role |
author |
author2 |
Slavov, Svetoslav Nanev Lima, Loyze Paola Oliveira de Lima, Alex Ranieri Jeronimo Ribeiro, Gabriela Martins, Antonio Jorge Petry, Bruna Banhode Souza Todao Lacerda Poleti, Mirele Daiana Assato, Patricia Akemi [UNESP] Cattony Neto, Pedro De Queiroz Cassano, Raquel de Lello Rocha Campos Machado Neto, Raul Grotto, Rejane Maria Tommasini [UNESP] Brassaloti, Ricardo Augusto Kashima, Simone Covas, Dimas Tadeu Elias, Maria Carolina Sampaio, Sandra Coccuzzo |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Butantan Institute Universidade de São Paulo (USP) Medicine School of São José do Rio Preto (FAMERP) Universidade Estadual Paulista (UNESP) Vigilância Epidemiológica de Ilhabela Hospital Mario Covas Junior Universidade Federal de Minas Gerais (UFMG) FIOCRUZ Oswaldo Cruz Foundation University of Campus Bio-Medico di Roma |
dc.contributor.author.fl_str_mv |
Viala, Vincent Louis Slavov, Svetoslav Nanev Lima, Loyze Paola Oliveira de Lima, Alex Ranieri Jeronimo Ribeiro, Gabriela Martins, Antonio Jorge Petry, Bruna Banhode Souza Todao Lacerda Poleti, Mirele Daiana Assato, Patricia Akemi [UNESP] Cattony Neto, Pedro De Queiroz Cassano, Raquel de Lello Rocha Campos Machado Neto, Raul Grotto, Rejane Maria Tommasini [UNESP] Brassaloti, Ricardo Augusto Kashima, Simone Covas, Dimas Tadeu Elias, Maria Carolina Sampaio, Sandra Coccuzzo |
dc.subject.por.fl_str_mv |
Brazil molecular epidemiology SARS-CoV-2 variants of concern (VOC) |
topic |
Brazil molecular epidemiology SARS-CoV-2 variants of concern (VOC) |
description |
Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-01 2023-03-01T20:17:31Z 2023-03-01T20:17:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/v14071481 Viruses, v. 14, n. 7, 2022. 1999-4915 http://hdl.handle.net/11449/240446 10.3390/v14071481 2-s2.0-85133926259 |
url |
http://dx.doi.org/10.3390/v14071481 http://hdl.handle.net/11449/240446 |
identifier_str_mv |
Viruses, v. 14, n. 7, 2022. 1999-4915 10.3390/v14071481 2-s2.0-85133926259 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Viruses |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128302755348480 |