The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela

Detalhes bibliográficos
Autor(a) principal: Viala, Vincent Louis
Data de Publicação: 2022
Outros Autores: Slavov, Svetoslav Nanev, Lima, Loyze Paola Oliveira de, Lima, Alex Ranieri Jeronimo, Ribeiro, Gabriela, Martins, Antonio Jorge, Petry, Bruna, Banhode Souza Todao Lacerda, Poleti, Mirele Daiana, Assato, Patricia Akemi [UNESP], Cattony Neto, Pedro De Queiroz, Cassano, Raquel de Lello Rocha Campos, Machado Neto, Raul, Grotto, Rejane Maria Tommasini [UNESP], Brassaloti, Ricardo Augusto, Kashima, Simone, Covas, Dimas Tadeu, Elias, Maria Carolina, Sampaio, Sandra Coccuzzo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/v14071481
http://hdl.handle.net/11449/240446
Resumo: Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.
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spelling The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of IlhabelaBrazilmolecular epidemiologySARS-CoV-2variants of concern (VOC)Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Butantan Institute, SPBlood Center of Ribeirão Preto Ribeirão Preto Medical School University of São Paulo, SPCentro de Genômica Funcional da ESALQ University of São Paulo, SPMedicine School of São José do Rio Preto (FAMERP), SPDepartment of Veterinary Medicine School of Animal Science and Food Engineering University of Sao Paulo, SPDepartment of Bioprocesses and Biotechnology School of Agricultural Sciences São Paulo State University (UNESP), SPSchool of Agricultural Sciences São Paulo State University (UNESP), SPVigilância Epidemiológica de Ilhabela, SPHospital Mario Covas Junior, SPInstituto de Ciências Biológicas Universidade Federal de Minas Gerais, MGInstituto Oswaldo Cruz FIOCRUZ, RJReference Laboratory of Flavivirus Oswaldo Cruz Foundation, RJDepartment of Science and Technology for Humans and the Environment University of Campus Bio-Medico di RomaMolecular Biology and Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School, SPDepartment of Bioprocesses and Biotechnology School of Agricultural Sciences São Paulo State University (UNESP), SPSchool of Agricultural Sciences São Paulo State University (UNESP), SPMolecular Biology and Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School, SPFAPESP: 18/15826-5FAPESP: 2020/06441-2FAPESP: 2020/10127-1Butantan InstituteUniversidade de São Paulo (USP)Medicine School of São José do Rio Preto (FAMERP)Universidade Estadual Paulista (UNESP)Vigilância Epidemiológica de IlhabelaHospital Mario Covas JuniorUniversidade Federal de Minas Gerais (UFMG)FIOCRUZOswaldo Cruz FoundationUniversity of Campus Bio-Medico di RomaViala, Vincent LouisSlavov, Svetoslav NanevLima, Loyze Paola Oliveira deLima, Alex Ranieri JeronimoRibeiro, GabrielaMartins, Antonio JorgePetry, BrunaBanhode Souza Todao LacerdaPoleti, Mirele DaianaAssato, Patricia Akemi [UNESP]Cattony Neto, Pedro De QueirozCassano, Raquel de Lello Rocha CamposMachado Neto, RaulGrotto, Rejane Maria Tommasini [UNESP]Brassaloti, Ricardo AugustoKashima, SimoneCovas, Dimas TadeuElias, Maria CarolinaSampaio, Sandra Coccuzzo2023-03-01T20:17:31Z2023-03-01T20:17:31Z2022-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/v14071481Viruses, v. 14, n. 7, 2022.1999-4915http://hdl.handle.net/11449/24044610.3390/v140714812-s2.0-85133926259Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVirusesinfo:eu-repo/semantics/openAccess2023-03-01T20:17:31Zoai:repositorio.unesp.br:11449/240446Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:00:10.417722Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
title The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
spellingShingle The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
Viala, Vincent Louis
Brazil
molecular epidemiology
SARS-CoV-2
variants of concern (VOC)
title_short The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
title_full The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
title_fullStr The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
title_full_unstemmed The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
title_sort The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela
author Viala, Vincent Louis
author_facet Viala, Vincent Louis
Slavov, Svetoslav Nanev
Lima, Loyze Paola Oliveira de
Lima, Alex Ranieri Jeronimo
Ribeiro, Gabriela
Martins, Antonio Jorge
Petry, Bruna
Banhode Souza Todao Lacerda
Poleti, Mirele Daiana
Assato, Patricia Akemi [UNESP]
Cattony Neto, Pedro De Queiroz
Cassano, Raquel de Lello Rocha Campos
Machado Neto, Raul
Grotto, Rejane Maria Tommasini [UNESP]
Brassaloti, Ricardo Augusto
Kashima, Simone
Covas, Dimas Tadeu
Elias, Maria Carolina
Sampaio, Sandra Coccuzzo
author_role author
author2 Slavov, Svetoslav Nanev
Lima, Loyze Paola Oliveira de
Lima, Alex Ranieri Jeronimo
Ribeiro, Gabriela
Martins, Antonio Jorge
Petry, Bruna
Banhode Souza Todao Lacerda
Poleti, Mirele Daiana
Assato, Patricia Akemi [UNESP]
Cattony Neto, Pedro De Queiroz
Cassano, Raquel de Lello Rocha Campos
Machado Neto, Raul
Grotto, Rejane Maria Tommasini [UNESP]
Brassaloti, Ricardo Augusto
Kashima, Simone
Covas, Dimas Tadeu
Elias, Maria Carolina
Sampaio, Sandra Coccuzzo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Butantan Institute
Universidade de São Paulo (USP)
Medicine School of São José do Rio Preto (FAMERP)
Universidade Estadual Paulista (UNESP)
Vigilância Epidemiológica de Ilhabela
Hospital Mario Covas Junior
Universidade Federal de Minas Gerais (UFMG)
FIOCRUZ
Oswaldo Cruz Foundation
University of Campus Bio-Medico di Roma
dc.contributor.author.fl_str_mv Viala, Vincent Louis
Slavov, Svetoslav Nanev
Lima, Loyze Paola Oliveira de
Lima, Alex Ranieri Jeronimo
Ribeiro, Gabriela
Martins, Antonio Jorge
Petry, Bruna
Banhode Souza Todao Lacerda
Poleti, Mirele Daiana
Assato, Patricia Akemi [UNESP]
Cattony Neto, Pedro De Queiroz
Cassano, Raquel de Lello Rocha Campos
Machado Neto, Raul
Grotto, Rejane Maria Tommasini [UNESP]
Brassaloti, Ricardo Augusto
Kashima, Simone
Covas, Dimas Tadeu
Elias, Maria Carolina
Sampaio, Sandra Coccuzzo
dc.subject.por.fl_str_mv Brazil
molecular epidemiology
SARS-CoV-2
variants of concern (VOC)
topic Brazil
molecular epidemiology
SARS-CoV-2
variants of concern (VOC)
description Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-01
2023-03-01T20:17:31Z
2023-03-01T20:17:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/v14071481
Viruses, v. 14, n. 7, 2022.
1999-4915
http://hdl.handle.net/11449/240446
10.3390/v14071481
2-s2.0-85133926259
url http://dx.doi.org/10.3390/v14071481
http://hdl.handle.net/11449/240446
identifier_str_mv Viruses, v. 14, n. 7, 2022.
1999-4915
10.3390/v14071481
2-s2.0-85133926259
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Viruses
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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