Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015

Detalhes bibliográficos
Autor(a) principal: Souza, Ana Carolina F. [UNESP]
Data de Publicação: 2018
Outros Autores: Pascoli, Ana Lucia, Ferreira, Marilia G. P. A. [UNESP], Reis Filho, Nazilton P. [UNESP], Silva, Izabel C. R., Santos, Rogerio R., Faro, Andre M., De Nardi, Andrigo B. [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-5150-PVB-5150
http://hdl.handle.net/11449/185035
Resumo: This study analyzed the cases of cutaneous mastocytomas in dogs seen at the Governador Laudo Natel Veterinary Hospital of the College of Agrarian and Veterinary Sciences (FCAV), Unesp, in Jaboticabal, from 2005 to 2015. The objective was to determine the occurrence of this neoplasm regarding breed, sex, and age, the most affected body parts and observed neoplastic characteristics; the most widely used diagnosis methods, the main histological grades and recommended treatments, to evaluate size changes in relation to lymph nodes, recurrence rate, metastasis and to verify possible associations between the evaluated variables. The clinical files of 192 patients were evaluated. The most affected dogs were of mixed breed (n=46, 23.96%), followed by Boxer (n=40, 20.83%) and Pitbull (n=27, 14.06%). Most of the dogs were females (n=107, 55.7%), aged between 7 and 11 years old (n=120, 62.5%). Thirty-two patients had (16.7%) tumors located in the pelvic limb, followed by thoracic limbs (10.4% n=20). Sixty-five animals had ulcerated nodules (33.9%), of which 96 had firm consistency (50%). Seventy-six animals had multiple nodules (39.6%), and 39.1% of the sample (n=75) had nodules larger than three centimeters. The most used diagnosis method was fine needle aspiration together with histopathology (HT), totaling 39.8% of nodules (n=66), followed by HT in 37.3% of the patients (n=62). Regarding the histological variables, 18 patients had grade I (11.8%), 112 grade II (73.7%), and 22 grade III (14.5%) classified according to Patnaik et al. (1984). According to the classification of Kiupel et al. (2011), 37 cases were classified as high grade (35.2%) and 68 as low grade (64.8%). Statistical association was observed when the presence of solitary/multiple nodules and the histological grade were evaluated according to Patnaik et al. (1984) (P=0.008) and Kiupel et al. (2011) (P=0.004). The nodules with worse prognostic feature were more frequent in animals diagnosed with multiple nodules, regardless of the histological classification used. The presence of multiple nodules in stage II or IV (p<0.001) and recurrence of the disease (p=0.001) was also observed. Regarding the histological classification of Kiupel et al. (2011), there was a statistical association between histological grade and tumor size (p=0.001), consistency (p=0.028) and nodule growth rate (p<0.001), lymph node enlargement (p<0.001) and the treatment used (p=0.002). Nodules larger than three centimeters (56.8% n=21) and fast growing (52.9% n=36%) were more frequent in high-grade tumors. Lymph node enlargement (80.6% n=25) and chemotherapeutic treatment (83.3% n=5) were also associated with patients with this histological grade. According to the classification of Patnaik et al. (1984), breed and sex differed proportionally between the histological groups (p=0.008 and 0.040 respectively), and lymph node enlargement and rapid tumor growth were also associated with histological grade (p=0.002 and 0.001). Almost half of the patients (47.4%) underwent surgical and chemotherapeutic treatment (n=91) while only surgical procedure was performed in 31.3% (n=60) of the patients. Sixty-one animals (31.8%) had enlarged regional lymph nodes (31.8%), and 71.9% of the nodes evaluated had rapid growth. The clinical evolution time of the tumor was less than or equal to one year in 158 patients (82.3%), followed by 1 to 2 years in 25 patients (13%). There were 66 cases (40.5%) of recurrence and 16 (8.3%) of distant metastasis. With this study, it can be concluded that dogs with mixed breed are the most affected by cutaneous mastocytoma in Jaboticabal city, followed by Boxer dogs, with ages varying between 7 and 11 years, with no sexual predisposition observed. It was also concluded that nodules were predominantly non-ulcerated, solitary and smaller than 3 centimeters, that the majority of patients presented grade II mastocytoma according to Patnaik et al. (1984) and low grade according to Kiupel et al. (2011), not being observed in most of them recurrence, lymph node or distance metastasis. The most commonly used diagnosis was fine-needle aspiration associated with histopathology, and in relation to location, nodules were found predominantly in pelvic and thoracic limbs, followed by head and neck. The consistency of the nodules was both firm and soft, and half of the patients underwent the associated surgical procedure of antineoplastic chemotherapy.
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spelling Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015Caninecutaneous mastcell tumorsoncologyJaboticabalBrazilneoplasmpathologyThis study analyzed the cases of cutaneous mastocytomas in dogs seen at the Governador Laudo Natel Veterinary Hospital of the College of Agrarian and Veterinary Sciences (FCAV), Unesp, in Jaboticabal, from 2005 to 2015. The objective was to determine the occurrence of this neoplasm regarding breed, sex, and age, the most affected body parts and observed neoplastic characteristics; the most widely used diagnosis methods, the main histological grades and recommended treatments, to evaluate size changes in relation to lymph nodes, recurrence rate, metastasis and to verify possible associations between the evaluated variables. The clinical files of 192 patients were evaluated. The most affected dogs were of mixed breed (n=46, 23.96%), followed by Boxer (n=40, 20.83%) and Pitbull (n=27, 14.06%). Most of the dogs were females (n=107, 55.7%), aged between 7 and 11 years old (n=120, 62.5%). Thirty-two patients had (16.7%) tumors located in the pelvic limb, followed by thoracic limbs (10.4% n=20). Sixty-five animals had ulcerated nodules (33.9%), of which 96 had firm consistency (50%). Seventy-six animals had multiple nodules (39.6%), and 39.1% of the sample (n=75) had nodules larger than three centimeters. The most used diagnosis method was fine needle aspiration together with histopathology (HT), totaling 39.8% of nodules (n=66), followed by HT in 37.3% of the patients (n=62). Regarding the histological variables, 18 patients had grade I (11.8%), 112 grade II (73.7%), and 22 grade III (14.5%) classified according to Patnaik et al. (1984). According to the classification of Kiupel et al. (2011), 37 cases were classified as high grade (35.2%) and 68 as low grade (64.8%). Statistical association was observed when the presence of solitary/multiple nodules and the histological grade were evaluated according to Patnaik et al. (1984) (P=0.008) and Kiupel et al. (2011) (P=0.004). The nodules with worse prognostic feature were more frequent in animals diagnosed with multiple nodules, regardless of the histological classification used. The presence of multiple nodules in stage II or IV (p<0.001) and recurrence of the disease (p=0.001) was also observed. Regarding the histological classification of Kiupel et al. (2011), there was a statistical association between histological grade and tumor size (p=0.001), consistency (p=0.028) and nodule growth rate (p<0.001), lymph node enlargement (p<0.001) and the treatment used (p=0.002). Nodules larger than three centimeters (56.8% n=21) and fast growing (52.9% n=36%) were more frequent in high-grade tumors. Lymph node enlargement (80.6% n=25) and chemotherapeutic treatment (83.3% n=5) were also associated with patients with this histological grade. According to the classification of Patnaik et al. (1984), breed and sex differed proportionally between the histological groups (p=0.008 and 0.040 respectively), and lymph node enlargement and rapid tumor growth were also associated with histological grade (p=0.002 and 0.001). Almost half of the patients (47.4%) underwent surgical and chemotherapeutic treatment (n=91) while only surgical procedure was performed in 31.3% (n=60) of the patients. Sixty-one animals (31.8%) had enlarged regional lymph nodes (31.8%), and 71.9% of the nodes evaluated had rapid growth. The clinical evolution time of the tumor was less than or equal to one year in 158 patients (82.3%), followed by 1 to 2 years in 25 patients (13%). There were 66 cases (40.5%) of recurrence and 16 (8.3%) of distant metastasis. With this study, it can be concluded that dogs with mixed breed are the most affected by cutaneous mastocytoma in Jaboticabal city, followed by Boxer dogs, with ages varying between 7 and 11 years, with no sexual predisposition observed. It was also concluded that nodules were predominantly non-ulcerated, solitary and smaller than 3 centimeters, that the majority of patients presented grade II mastocytoma according to Patnaik et al. (1984) and low grade according to Kiupel et al. (2011), not being observed in most of them recurrence, lymph node or distance metastasis. The most commonly used diagnosis was fine-needle aspiration associated with histopathology, and in relation to location, nodules were found predominantly in pelvic and thoracic limbs, followed by head and neck. The consistency of the nodules was both firm and soft, and half of the patients underwent the associated surgical procedure of antineoplastic chemotherapy.Univ Estadual Paulista, Dept Clin & Cirurgia Vet, UNESP, FCAV, Via Acesso Prof Paulo Donato Castelane, BR-14884900 Jaboticabal, SP, BrazilUniv Reg Blumenau FURB, Tecn & Clin Cirurg Pequenos Anim, Rua Antonio Veiga 140, BR-89012900 Blumenau, SC, BrazilUniv Estadual Paulista, UNESP, Med Vet, FCAV, Via Acesso Prof Paulo Donato Castelane, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, UNESP, Cirurgia Vet, FCAV, Via Acesso Prof Paulo Donato Castelane, BR-14884900 Jaboticabal, SP, BrazilUniv Brasilia UnB, Fac Ceilandia, Ctr Metropolitano, Conjunto A,Lote 1, BR-72220275 Brasilia, DF, BrazilRua Qi 6,Casa 104,Guara 1, BR-71810214 Brasilia, DF, BrazilIFC, Serv Cirurgia Vet, Colegio Agr, Campus Araquari,Rodovia BR 280 Km 27, BR-89245000 Araquari, SC, BrazilUniv Estadual Paulista, Dept Clin & Cirurgia Vet, UNESP, FCAV, Via Acesso Prof Paulo Donato Castelane, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, UNESP, Med Vet, FCAV, Via Acesso Prof Paulo Donato Castelane, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, UNESP, Cirurgia Vet, FCAV, Via Acesso Prof Paulo Donato Castelane, BR-14884900 Jaboticabal, SP, BrazilRevista Pesquisa Veterinaria BrasileiraUniversidade Estadual Paulista (Unesp)Univ Reg Blumenau FURBUniv Brasilia UnBIFCSouza, Ana Carolina F. [UNESP]Pascoli, Ana LuciaFerreira, Marilia G. P. A. [UNESP]Reis Filho, Nazilton P. [UNESP]Silva, Izabel C. R.Santos, Rogerio R.Faro, Andre M.De Nardi, Andrigo B. [UNESP]2019-10-04T12:32:10Z2019-10-04T12:32:10Z2018-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1808-1817application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-5150Pesquisa Veterinaria Brasileira. Rio Janeiro: Revista Pesquisa Veterinaria Brasileira, v. 39, n. 9, p. 1808-1817, 2018.0100-736Xhttp://hdl.handle.net/11449/18503510.1590/1678-5150-PVB-5150S0100-736X2018000901808WOS:000449559300015S0100-736X2018000901808.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2024-06-06T14:10:35Zoai:repositorio.unesp.br:11449/185035Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:58:03.118322Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015
title Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015
spellingShingle Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015
Souza, Ana Carolina F. [UNESP]
Canine
cutaneous mast
cell tumors
oncology
Jaboticabal
Brazil
neoplasm
pathology
title_short Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015
title_full Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015
title_fullStr Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015
title_full_unstemmed Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015
title_sort Canine cutaneous mast cell tumors: retrospective study of cases attended by the oncology service at the Veterinary Hospital of FCAV-Unesp, Jaboticabal, from 2005 to 2015
author Souza, Ana Carolina F. [UNESP]
author_facet Souza, Ana Carolina F. [UNESP]
Pascoli, Ana Lucia
Ferreira, Marilia G. P. A. [UNESP]
Reis Filho, Nazilton P. [UNESP]
Silva, Izabel C. R.
Santos, Rogerio R.
Faro, Andre M.
De Nardi, Andrigo B. [UNESP]
author_role author
author2 Pascoli, Ana Lucia
Ferreira, Marilia G. P. A. [UNESP]
Reis Filho, Nazilton P. [UNESP]
Silva, Izabel C. R.
Santos, Rogerio R.
Faro, Andre M.
De Nardi, Andrigo B. [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Univ Reg Blumenau FURB
Univ Brasilia UnB
IFC
dc.contributor.author.fl_str_mv Souza, Ana Carolina F. [UNESP]
Pascoli, Ana Lucia
Ferreira, Marilia G. P. A. [UNESP]
Reis Filho, Nazilton P. [UNESP]
Silva, Izabel C. R.
Santos, Rogerio R.
Faro, Andre M.
De Nardi, Andrigo B. [UNESP]
dc.subject.por.fl_str_mv Canine
cutaneous mast
cell tumors
oncology
Jaboticabal
Brazil
neoplasm
pathology
topic Canine
cutaneous mast
cell tumors
oncology
Jaboticabal
Brazil
neoplasm
pathology
description This study analyzed the cases of cutaneous mastocytomas in dogs seen at the Governador Laudo Natel Veterinary Hospital of the College of Agrarian and Veterinary Sciences (FCAV), Unesp, in Jaboticabal, from 2005 to 2015. The objective was to determine the occurrence of this neoplasm regarding breed, sex, and age, the most affected body parts and observed neoplastic characteristics; the most widely used diagnosis methods, the main histological grades and recommended treatments, to evaluate size changes in relation to lymph nodes, recurrence rate, metastasis and to verify possible associations between the evaluated variables. The clinical files of 192 patients were evaluated. The most affected dogs were of mixed breed (n=46, 23.96%), followed by Boxer (n=40, 20.83%) and Pitbull (n=27, 14.06%). Most of the dogs were females (n=107, 55.7%), aged between 7 and 11 years old (n=120, 62.5%). Thirty-two patients had (16.7%) tumors located in the pelvic limb, followed by thoracic limbs (10.4% n=20). Sixty-five animals had ulcerated nodules (33.9%), of which 96 had firm consistency (50%). Seventy-six animals had multiple nodules (39.6%), and 39.1% of the sample (n=75) had nodules larger than three centimeters. The most used diagnosis method was fine needle aspiration together with histopathology (HT), totaling 39.8% of nodules (n=66), followed by HT in 37.3% of the patients (n=62). Regarding the histological variables, 18 patients had grade I (11.8%), 112 grade II (73.7%), and 22 grade III (14.5%) classified according to Patnaik et al. (1984). According to the classification of Kiupel et al. (2011), 37 cases were classified as high grade (35.2%) and 68 as low grade (64.8%). Statistical association was observed when the presence of solitary/multiple nodules and the histological grade were evaluated according to Patnaik et al. (1984) (P=0.008) and Kiupel et al. (2011) (P=0.004). The nodules with worse prognostic feature were more frequent in animals diagnosed with multiple nodules, regardless of the histological classification used. The presence of multiple nodules in stage II or IV (p<0.001) and recurrence of the disease (p=0.001) was also observed. Regarding the histological classification of Kiupel et al. (2011), there was a statistical association between histological grade and tumor size (p=0.001), consistency (p=0.028) and nodule growth rate (p<0.001), lymph node enlargement (p<0.001) and the treatment used (p=0.002). Nodules larger than three centimeters (56.8% n=21) and fast growing (52.9% n=36%) were more frequent in high-grade tumors. Lymph node enlargement (80.6% n=25) and chemotherapeutic treatment (83.3% n=5) were also associated with patients with this histological grade. According to the classification of Patnaik et al. (1984), breed and sex differed proportionally between the histological groups (p=0.008 and 0.040 respectively), and lymph node enlargement and rapid tumor growth were also associated with histological grade (p=0.002 and 0.001). Almost half of the patients (47.4%) underwent surgical and chemotherapeutic treatment (n=91) while only surgical procedure was performed in 31.3% (n=60) of the patients. Sixty-one animals (31.8%) had enlarged regional lymph nodes (31.8%), and 71.9% of the nodes evaluated had rapid growth. The clinical evolution time of the tumor was less than or equal to one year in 158 patients (82.3%), followed by 1 to 2 years in 25 patients (13%). There were 66 cases (40.5%) of recurrence and 16 (8.3%) of distant metastasis. With this study, it can be concluded that dogs with mixed breed are the most affected by cutaneous mastocytoma in Jaboticabal city, followed by Boxer dogs, with ages varying between 7 and 11 years, with no sexual predisposition observed. It was also concluded that nodules were predominantly non-ulcerated, solitary and smaller than 3 centimeters, that the majority of patients presented grade II mastocytoma according to Patnaik et al. (1984) and low grade according to Kiupel et al. (2011), not being observed in most of them recurrence, lymph node or distance metastasis. The most commonly used diagnosis was fine-needle aspiration associated with histopathology, and in relation to location, nodules were found predominantly in pelvic and thoracic limbs, followed by head and neck. The consistency of the nodules was both firm and soft, and half of the patients underwent the associated surgical procedure of antineoplastic chemotherapy.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-01
2019-10-04T12:32:10Z
2019-10-04T12:32:10Z
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dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-5150-PVB-5150
Pesquisa Veterinaria Brasileira. Rio Janeiro: Revista Pesquisa Veterinaria Brasileira, v. 39, n. 9, p. 1808-1817, 2018.
0100-736X
http://hdl.handle.net/11449/185035
10.1590/1678-5150-PVB-5150
S0100-736X2018000901808
WOS:000449559300015
S0100-736X2018000901808.pdf
url http://dx.doi.org/10.1590/1678-5150-PVB-5150
http://hdl.handle.net/11449/185035
identifier_str_mv Pesquisa Veterinaria Brasileira. Rio Janeiro: Revista Pesquisa Veterinaria Brasileira, v. 39, n. 9, p. 1808-1817, 2018.
0100-736X
10.1590/1678-5150-PVB-5150
S0100-736X2018000901808
WOS:000449559300015
S0100-736X2018000901808.pdf
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dc.relation.none.fl_str_mv Pesquisa Veterinaria Brasileira
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dc.format.none.fl_str_mv 1808-1817
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dc.publisher.none.fl_str_mv Revista Pesquisa Veterinaria Brasileira
publisher.none.fl_str_mv Revista Pesquisa Veterinaria Brasileira
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reponame:Repositório Institucional da UNESP
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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