Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2017/4637621 http://hdl.handle.net/11449/170250 |
Resumo: | Our aim was to verify the effects of prednisone related to gastrointestinal motility, intestinal histology, and mucosal mast cells in rats. Two-month-old male Wistar rats were randomly assigned to control group (vehicle) animals receiving saline 0.9% (n=7) or treated orally with 0.625 mg/kg/day of prednisone (n=7) or 2.5 mg/kg/day of prednisone (n=7) during 15 days. Mast cells and other histologic analyses were performed in order to correlate to gastric emptying, cecum arrival, and small intestine transit evaluated by Alternating Current Biosusceptometry. Results showed that prednisone in adult rats increased the frequency of gastric contractions, hastened gastric emptying, slowed small intestinal transit, and reduced mucosal mast cells. Histologically, the treatment with both doses of prednisone decreased villus height, whereas longitudinal and circular muscles and crypt depth were not affected. These findings indicate an impairment of intestinal absorption which may be linked to several GI dysfunctions and symptoms. The relationship between gastrointestinal motor disorders and cellular immunity needs to be clarified in experimental studies since prednisone is one of the most prescribed glucocorticoids worldwide. |
id |
UNSP_f7cfa59482bd5f988302a6c86888435b |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/170250 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of PrednisoneOur aim was to verify the effects of prednisone related to gastrointestinal motility, intestinal histology, and mucosal mast cells in rats. Two-month-old male Wistar rats were randomly assigned to control group (vehicle) animals receiving saline 0.9% (n=7) or treated orally with 0.625 mg/kg/day of prednisone (n=7) or 2.5 mg/kg/day of prednisone (n=7) during 15 days. Mast cells and other histologic analyses were performed in order to correlate to gastric emptying, cecum arrival, and small intestine transit evaluated by Alternating Current Biosusceptometry. Results showed that prednisone in adult rats increased the frequency of gastric contractions, hastened gastric emptying, slowed small intestinal transit, and reduced mucosal mast cells. Histologically, the treatment with both doses of prednisone decreased villus height, whereas longitudinal and circular muscles and crypt depth were not affected. These findings indicate an impairment of intestinal absorption which may be linked to several GI dysfunctions and symptoms. The relationship between gastrointestinal motor disorders and cellular immunity needs to be clarified in experimental studies since prednisone is one of the most prescribed glucocorticoids worldwide.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Federal University of Mato Grosso UFMTSão Paulo State University UNESPAlagoas State University of Health Sciences UNCISALSão Paulo State University UNESPUFMTUniversidade Estadual Paulista (Unesp)UNCISALDe Lima, Maysa BrunoGama, Loyane Almeida [UNESP]Hauschildt, Andrieli TaiseDall'Agnol, Denize Jussara Rupolo [UNESP]Corá, Luciana AparecidaAmerico, Madileine Francely2018-12-11T16:49:56Z2018-12-11T16:49:56Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2017/4637621BioMed Research International, v. 2017.2314-61412314-6133http://hdl.handle.net/11449/17025010.1155/2017/46376212-s2.0-850307714882-s2.0-85030771488.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioMed Research International0,9350,935info:eu-repo/semantics/openAccess2023-11-07T06:14:55Zoai:repositorio.unesp.br:11449/170250Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:06:36.456079Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone |
title |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone |
spellingShingle |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone De Lima, Maysa Bruno |
title_short |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone |
title_full |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone |
title_fullStr |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone |
title_full_unstemmed |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone |
title_sort |
Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone |
author |
De Lima, Maysa Bruno |
author_facet |
De Lima, Maysa Bruno Gama, Loyane Almeida [UNESP] Hauschildt, Andrieli Taise Dall'Agnol, Denize Jussara Rupolo [UNESP] Corá, Luciana Aparecida Americo, Madileine Francely |
author_role |
author |
author2 |
Gama, Loyane Almeida [UNESP] Hauschildt, Andrieli Taise Dall'Agnol, Denize Jussara Rupolo [UNESP] Corá, Luciana Aparecida Americo, Madileine Francely |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
UFMT Universidade Estadual Paulista (Unesp) UNCISAL |
dc.contributor.author.fl_str_mv |
De Lima, Maysa Bruno Gama, Loyane Almeida [UNESP] Hauschildt, Andrieli Taise Dall'Agnol, Denize Jussara Rupolo [UNESP] Corá, Luciana Aparecida Americo, Madileine Francely |
description |
Our aim was to verify the effects of prednisone related to gastrointestinal motility, intestinal histology, and mucosal mast cells in rats. Two-month-old male Wistar rats were randomly assigned to control group (vehicle) animals receiving saline 0.9% (n=7) or treated orally with 0.625 mg/kg/day of prednisone (n=7) or 2.5 mg/kg/day of prednisone (n=7) during 15 days. Mast cells and other histologic analyses were performed in order to correlate to gastric emptying, cecum arrival, and small intestine transit evaluated by Alternating Current Biosusceptometry. Results showed that prednisone in adult rats increased the frequency of gastric contractions, hastened gastric emptying, slowed small intestinal transit, and reduced mucosal mast cells. Histologically, the treatment with both doses of prednisone decreased villus height, whereas longitudinal and circular muscles and crypt depth were not affected. These findings indicate an impairment of intestinal absorption which may be linked to several GI dysfunctions and symptoms. The relationship between gastrointestinal motor disorders and cellular immunity needs to be clarified in experimental studies since prednisone is one of the most prescribed glucocorticoids worldwide. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T16:49:56Z 2018-12-11T16:49:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2017/4637621 BioMed Research International, v. 2017. 2314-6141 2314-6133 http://hdl.handle.net/11449/170250 10.1155/2017/4637621 2-s2.0-85030771488 2-s2.0-85030771488.pdf |
url |
http://dx.doi.org/10.1155/2017/4637621 http://hdl.handle.net/11449/170250 |
identifier_str_mv |
BioMed Research International, v. 2017. 2314-6141 2314-6133 10.1155/2017/4637621 2-s2.0-85030771488 2-s2.0-85030771488.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BioMed Research International 0,935 0,935 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128756616790016 |